Melvyn Bragg and guests discuss how perceptions of science and the power of science have changed in the 20th century. Does scientific endeavour increasingly concern itself with doubt rather than certainty, and is it coming any closer to integrating with other disciplines - philosophy or the social sciences? How much does the scientific explanation of the world owe to a wish for coherent understanding we all have, rather than objective observation, and why are we alternately disapproving of, then obsessively over-enthusiastic about new scientific theories? How far has specialisation in the sciences obscured our view of the world in its entirety, and if scientists want to operate within a social framework, can they do so and still claim to be objective and value-free in their findings?With John Gribbin, Visiting Fellow in Astronomy, University of Sussex and consultant to New Scientist; Mary Midgley, moral philosopher and former Senior Lecturer in Philosophy, University of Newcastle.

Melvyn Bragg and guests discuss whether the mass of scientific understanding and knowledge we have accumulated has destroyed our sense of poetic wonder at the world. Has our sense of awe at how the world works obscured our desire to know why it works the way it does? With Richard Dawkins evolutionary biologist, reader in Zoology and Fellow of New College, Oxford, Charles Simonyi Chair of Public Understanding of Science, Oxford University and author of Unweaving The Rainbow: Science, Delusion and The Appetite For Wonder; Ian McEwan, novelist, and author of the Booker prize winning novel Amsterdam.