Jasmina Aganovic is a cosmetics and consumer goods entrepreneur who received her degree in chemical and biological engineering from MIT, and she’s back on the podcast to talk about the progress AOBiome have made with their clinical trials. In this interview, we focus mostly on the potential treatment of acne and hypertension, but trials are also underway for allergies, eczema, wound healing, migraines and temperature regulation.

Mother Dirt is the company focussed on commercialising the research of AOBiome, and I’ve been using their AO+ Mist spray product for over two years for the successful prevention of nappy (diaper) rash, saddle sores, and acne caused by bike helmets. I’ve also been using the spray in the place of a deodorant, and so far my wife hasn’t divorced me. Jasmina wanted to make it clear that although my N=1 experiences are exciting, nothing has been FDA approved.

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Here’s the outline of this interview with Jasmina Aganovic:

[00:03:43] Environmental changes are leading to the loss of the ammonia oxidising (AO) bacteria.

[00:05:14] Nitrogen cycle.

[00:07:18] David Whitlock is the Inventor and co-founder of AOBiome.

[00:07:34] Why horses roll in the dirt in March?

[00:08:36] The link between the skin and the soil.

[00:09:36] Developing a bioreactor.

[00:10:28] Nappy rash.

[00:11:05] Bicycle helmets.

[00:13:11] The scientific process to validate the claims.

[00:13:55] Phase II trials for acne.

[00:14:26] A potential replacement for antiperspirant deodorant.

[00:14:50] Prevention of saddle sores.

[00:15:36] The war on P. acne.

[00:16:49] It's all about balance.

[00:17:23] C. diff overgrowths.

[00:18:49] Mechanism of action: acid, base balance.

[00:19:44] Nitrite and Nitric oxide.

[00:20:55] Not nitrous oxide! Which mucks up methylation by oxidising cobalamin.

[00:21:52] Hypertension.

[00:24:05] Highlights sign-up.

[00:25:09] Can nitric oxide made by the bacteria on the skin become systemic?

[00:26:47] Why FDA approval.

[00:29:37] Adverse events.

[00:30:47] Drug: B244 on clinicaltrials.gov.

[00:31:16] Romaine Bardet came 2nd in the Tour de France.

[00:32:28] Increasing O2 deliverability.

[00:33:46] Personal care product compatibility.

[00:34:11] Surfactant sodium octyl sulfate (SOS) and sodium dodecyl sulfate (SDS) surfactants.

[00:35:13] Castille and neem soap.

[00:36:11] Nurses and hand sanitisers.

[00:37:59] http://www.nourishbalancethrive.com/dirt/ use discount code NBT25.

[00:38:35] Mother Dirt is the consumer-facing site, to learn about the clinical research go to AOBiome.