View all show notes and timestamps on the KoopCast website.

Episode overview:

Chiel Poffe is a Postdoctoral researcher at KU Leven. His areas of focus are energy metabolism and ketones.

Episode highlights:

(32:56) Practical ketone use: best during high-intensity training, 25g after exercise and before sleep, individual variance, potential improved sleep, muscle recovery, cognitive benefits, cost

(39:38) Ultramarathon study results: complications with investigating performance, reaction time test, no cognitive decline in ketone groups, ketone increase dopamine levels, mechanistic speculation

(45:19) Ketones aid cognition in extreme circumstances: revisiting study design, parallels to the overtraining study, ketones inhibit cognitive decline rather than improving cognition, support from initial ketone research

Additional resources:

Chiel on Twitter

Ketone ester supplementation blunts overreaching symptoms during endurance training overload

Exogenous ketosis increases circulating dopamine concentration and maintains mental alertness in ultra-endurance exercise

Outside Online’s dumb headline that ketones cure overtraining

Research Essentials for Ultrarunning: https://www.jasonkoop.com/research-essentials-for-ultrarunning

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