This week we uncover the secret to a longer, healthier life as we sit down with Dr Buck Joffrey, a former neurosurgery and otolaryngology resident turned cosmetic surgeon and serial entrepreneur. Buck’s journey from the operating room to the forefront of longevity science was ignited by a personal health scare and fueled by the pioneering work of David Sinclair. Join us as Buck shares his transformative story, emphasizing the profound impact of lifestyle changes like diet, exercise, and sleep on extending our lifespans, and even hints at the tantalizing possibility of age reversal.

Explore the groundbreaking science of epigenetics and its crucial role in the aging process. We dissect how chemical modifications such as DNA methylation can alter gene expression and affect our biological clocks. With insights from researchers like Steve Horvath, we delve into how epigenetic clocks can predict biological age and mortality risk. Discover the potential of reversing epigenetic age through lifestyle choices, proper nutrition, and medications like rapamycin. Buck also underscores the vital need to manage inflammation and metabolic syndrome to mitigate age-related diseases.

This episode also delves into holistic health optimization, covering the interplay between nutrition, exercise, and sleep. We discuss the alarming decline in testosterone levels in men and its implications for metabolic health and longevity. The conversation navigates the delicate balance between optimizing for longevity versus performance, shedding light on the Goldilocks effect of exercise. To top it off, we emphasize the importance of educating the public on these critical insights, ensuring that more people have access to life-extending knowledge.

https://www.sapiopodcast.com/

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