Cheyenne Jackson's journey began as a closeted musical-loving kid in a tiny town in Idaho. He has gone on to star in 7 broadway shows and a mirriade of film and TV projects.  He's currently co-starring as Mayim's love interest in their new Fox show Call Me Kat.  In this episode, Cheyenne opens up and shares touching stories on how sobriety helped him define his path as he navigated depression, anxiety, and addiction.

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Mayim Breaks down the chemical and environmental aspects of addiction and The Big Bang Theory actor John Ross Bowie shares his story of being an angry young man who turned to alcohol to numb his pain. This touching exploration of John's journey allows him to share aspects of his sobriety and his struggles as a father and actor which he had not previously explored. 

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Bill Prady, co-creator of "The Big Bang Theory," discusses how he came up with the idea to make a show about socially challenged scientists. What many may not know is that Prady himself is on the autism spectrum. Mayim explains "neuro-a typical' and sensory overload, Bill opens up about his quirks and challenges and shares intimately about his journey from awkward child and teen to well-adjusted, if eccentric, adult.

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Mayim breaks down how our overall stress can have real physical impacts and Iliza Shlesinger discusses being a female stand up comedian among men in her profession, how we as a society struggle to communicate, and how her hectic work life caught up with her in the form of debilitating nerve pain. This plus lots of jokes on Ep 3 of the show!

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Mayim explores the neurobiology and neuroanatomical differences between gay and straight men while the beloved comedian Leslie Jordan shares his personal struggles with crystal meth and alcoholism. He discusses growing up gay in the south at a time when no one talked about gay rights and he reflects on starting his first serious relationship in his 50s and how sobriety has allowed him access to aspects of his mental health and love life he had never experienced.

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Mayim & Grace Helbig break down anxiety - why we have it and how it impacts many of us.  

Grace takes us on a journey through her childhood as a young comedian and why she chose to become a "comedian from home."  Grace also shares hilarious anecdotes about how she has managed her anxiety, her dating life, difficult conversations, and a flourishing career. Grace reveals her inspiration for pursuing a graduate degree in Depth psychology and puts on her doctor hat to offer Mayim and Jonathan some needed advice. 

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