Matthew Baggott discusses the phenomenon of "losing the magic" with MDMA use, where frequent users experience diminishing therapeutic effects over time, likely due to decreased serotonin transporters in the brain; as well as N-Acetyl Cysteine (NAC) supplementation as a potential avenue for getting the magic back. 

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This is a clip from 'Entactogens, MDMA, and Bringing New Love Drugs To Market | Matthew Baggott ~ ATTMind Podcast 177'

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