In this video Dr. Sabatini discusses his recent paper and in particular  how the health of the mitochondria impact the activation of mTOR and how  this is signaled. 

Dr. David Sabatini is an American scientist and Professor of Biology at  the Massachusetts Institute of Technology as well as a member of the  Whitehead Institute for Biomedical Research. He is known for his  important contributions in the areas of cell signaling and cancer  metabolism, most notably the discovery of mTOR, more than 20 years ago.  Since then Dr. Sabatini has continued to work on better understanding  this complex regulator of our metabolism  Some key references. 

The paper discussed in the video.  Genome-wide CRISPR screens reveal multitiered mechanisms through which  mTORC1 senses mitochondrial dysfunction 

https://www.biorxiv.org/content/10.1101/2020.10.22.351361v1.full.pdf  

Twenty-five years of mTOR: Uncovering the link from nutrients to growth 

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5692607/