In this video Dr. Sabatini discusses rapamycin, how it acts on mTORC1  and mTORC2 and the rapalogs, drugs which are similar to rapamycin but  may be more clinically effective.   

Dr. David Sabatini is an American scientist and Professor of Biology at  the Massachusetts Institute of Technology as well as a member of the  Whitehead Institute for Biomedical Research. He is known for his  important contributions in the areas of cell signaling and cancer  metabolism, most notably the discovery of mTOR, more than 20 years ago.  Since then Dr. Sabatini has continued to work on better understanding  this complex regulator of our metabolism  

Some key references. 

Genome-wide CRISPR screens reveal multitiered mechanisms through which mTORC1 senses mitochondrial dysfunction https://www.biorxiv.org/content/10.1101/2020.10.22.351361v1.full.pdf  

Twenty-five years of mTOR: Uncovering the link from nutrients to growth https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5692607/  

mTOR introduction YouTube Series with Dr. Sabatini 

https://www.youtube.com/watch?v=EnIerDljc7g

https://www.youtube.com/watch?v=defOfBEuw_M 

https://www.youtube.com/watch?v=tGA9RALG66s