Peptide of the Week | Weight Loss, Health & Wellness

We are not doctors. The content in this video is for educational and informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease. Any compounds discussed may be intended for research purposes only. Use at your own risk.
Welcome back, warriors! In this week’s Peptide Q&A, JD Denham and William T. Haas break down real-world protocols for fat loss, brain performance, longevity, and how to build stacks that actually match your goals plus a deep dive into peptide safety and sourcing. No fluff. No scripts. Just straight talk from experience.
Chapters:00:09 Intro, Rainy Day Banter & Q&A Format Explained 03:10 Why Different Personalities Make the Podcast Work08:30 Stalled Fat Loss on GLPs & When to Switch Compounds17:20 Bodyweight Training, Muscle Loss & Metabolism22:40 Reta Stacks for Fat Loss Without Losing Muscle31:00 Fasting, Food Timing & Peptide Use38:20 Vetting Peptide Companies, COAs & Pricing Reality48:40 TRT, Libido Issues & Estrogen Troubleshooting57:10 CJC-1295 With vs Without DAC (First-Time Use)1:00:10 Best Fat Loss Stacks to Run With Reta1:09:45 SS-31, Mitochondria & Cardiovascular Support1:11:10 When Surgery Beats Peptides for Healing1:12:15 Podcast Growth, Future Plans & Outro
We cover:🧠 Semax & Selank Longevity: BDNF, neuroplasticity, cycling vs continuous use, performance timing, and anxiety dosing strategies🏋️ Ex-Powerlifter Recomp Plan: TRT + RETA setup, AOD, SLU-PP-332, 5-Amino-1MQ, GH for muscle retention, and how to train heavy for fat loss🔥 Training for Body Recomposition: Short rest periods, compound lifts, fasting integration, and hitting muscles twice per week for metabolic output👩 Low-Dose RETA for Women: When to titrate up, why lowest effective dose matters, preserving muscle with Tesa-IPA, and where KPV fits🍽️ RETA Reality Check: Appetite control vs starvation, habit change, food quality, and why it’s not a magic shot🧬 Thyroid Cancer Warning Explained: Rodent data vs human risk, MEN2 history, quality-of-life decision making, and doctor conversations that matter⚙️ What to Stack with RETA: Fat-loss stacks vs mitochondria, anti-aging protocols, NAD timing, and GH for 40+ optimization📉 Long-Term Low-Dose RETA: Metabolic health benefits, desensitization myths, titrating down vs coming off, and maintenance strategy🏃 Endurance Athletes & Fueling Issues: When RETA suppresses calories too much, MK-677/IPA for appetite, GH timing, and recovery support📦 Peptide Safety & Contamination: China raws vs U.S. bottling, endotoxin testing, heavy metals, COAs, real cost of proper testing, and how to vet companies🫀 Heart Health & SS-31: Mitochondrial integrity, energy utilization, and realistic expectations with structural conditions🌍 Lifestyle Over Peptides: Why training, movement, diet, and daily activity are still the foundation everything else amplifies🎙️ What’s Next for the Podcast: Possible guest episodes and expanding education for women’s hormones
💡 Peptides amplify the work they don’t replace it. Dial in training, nutrition, recovery, and lifestyle to unlock their real power.
📌 Subscribe for weekly, no-fluff protocols, dosing guidance, and real-world results.
You’re a warrior. Act like one.
Follow us on social media: JD's Instagram: https://www.instagram.com/jd_denham_fitWill's Instagram: https://www.instagram.com/williamthaas/Warrior-Makers page: https://www.instagram.com/warrior_makers_supplements/

Become a supporter of this podcast: https://www.spreaker.com/podcast/peptide-of-the-week-weight-loss-health-wellness--7447107/support.

We are not doctors. The content in this video is for educational and informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease. Any compounds discussed may be intended for research purposes only. Use at your own risk.
Welcome back, warriors! In this episode of Peptide of the Week, JD Denham and William T. Haas sit down with Dr. Tyler from Action TRT to break down the real root of modern men’s health decline low testosterone and the foundational protocols that are changing lives: TRT, HCG, and Growth Hormone.
From why testosterone levels are crashing in younger men to the truth about estrogen, fertility, libido, and long-term optimization, this episode is a masterclass in building the hormonal base that everything else depends on.
Chapters:00:09 Intro & Why Testosterone Is So Low Today 02:40 How a Proper TRT Clinic Evaluates New Patients06:15 Total vs Free vs Bioavailable Testosterone Explained11:00 HCG: Fertility, Testicular Function & Mental Benefits16:45 Enclomiphene vs HCG (What Actually Works Long Term)22:30 TRT Dosing Mistakes & The AI/Estrogen Debate30:05 Stop Chasing Numbers Treat Symptoms & Performance35:45 Injection Methods, Frequency & Why Pellets Fall Short42:00 Testosterone + Growth Hormone for Longevity46:00 Top Peptides Right Now (Reta, Tesamorelin, BPC-157)50:55 How to Start TRT the Right Way & Clinic Philosophy53:20 Low Libido on TRT What’s Really Happening54:40 Outro
We cover:🧬 Why testosterone is at epidemic-level lows– Environmental toxins, plastics, pesticides, food quality & lifestyle– Why today’s 30-year-olds have the levels of older generations in decline– The real symptoms that bring men into the clinic: fatigue, mood, fat gain, low drive
🧪 The lab work that actually matters– Total vs Free vs Bioavailable testosterone explained in real terms– Why most traditional clinics miss the full hormonal picture– Thyroid, CMP, PSA, SHBG, estrogen & metabolic markers
💉 TRT done correctly vs cookie-cutter protocols– Why one-size-fits-all dosing fails– Injection frequency & why twice per week is the modern standard– SubQ vs IM: absorption, stability, and real-world application– Why pellets and creams often limit precision and adjustment
🔥 HCG – the “special sauce” of TRT– Keeps natural production active & preserves fertility– Prevents testicular shutdown– Supports mental well-being & hormonal balance– Why running TRT without it can create long-term issues– Fertility protocols and real patient success stories
⚖️ Enclomiphene vs HCG – what actually works long term– Why oral stimulation fails for many men– Pituitary response variability– Side effects: mood swings, headaches, crashing levels– The difference between temporary lab improvements and real symptom resolution
❤️ Estrogen in men – the most misunderstood hormone– 50% of libido & erectile function comes from estrogen– Why crushing estrogen destroys performance & sex drive– The difference between metabolic high estrogen vs TRT-optimized conversion– Why symptom resolution matters more than chasing lab ratios
🚀 Growth Hormone the longevity multiplier– Low-dose GH for recovery, fat loss, sleep & cellular repair– Why it’s called the “fountain of youth” in clinical practice– The synergy of optimized testosterone + GH– Performance, energy, and long-term health benefits
📊 Optimization is individualized– There is no universal “perfect number”– The real metric: energy, performance, recovery, libido, sleep & body composition– Small dose adjustments that create massive quality-of-life changes
🧪 This is real clinical experience, real patient outcomes, and real protocols not forum theory.

Become a supporter of this podcast: https://www.spreaker.com/podcast/peptide-of-the-week-weight-loss-health-wellness--7447107/support.

Medical Disclaimer: We are not doctors. The content in this video is for educational and informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease. Any compounds discussed may be intended for research purposes only. Use at your own risk.
Welcome back, warriors! In this week’s Peptide Q&A, JD Denham and William T. Haas open up with gratitude, growth, and real talk about discipline then dive deep into hormone issues, peptide stacking, libido struggles, and practical injection strategies. No fluff. No scripts. Just experience.
Chapters:00:09 Gratitude, Growth & How the Podcast Started 09:44 Finasteride, DHT & Back Acne17:14 Mixing Peptides, Reconstitution & Travel Storage29:09 DSIP Dosing & Sleep Optimization31:09 Glow Serum, Sloop Tabs & Naltrexone38:19 Adipotide, Thymalin & Immune Peptides42:29 Wolverine Stack: Dosing for Maintenance vs Injury46:29 TRT Libido Issues & Hormone Troubleshooting58:54 CJC/IPA, Fat Loss Stacks & Retatrutide1:02:29 TRT for Older Men1:03:39 GHK-Cu Topical vs Injectable + Water Retention in Women1:07:54 Upcoming Guests & Outro
We cover:🔥 Back Acne on TRT: Why estrogen not DHT  is usually the culprit, when (and when NOT) to use AIs, and the truth about finasteride vs dutasteride💉 Estrogen Management: Injection frequency, SHBG, prolactin, and how poor AI timing can actually make things worse🧠 Libido Loss on TRT: Why erections can be psychological AND hormonal, prolactin considerations, cabergoline, calming peptides, and performance anxiety💊 Cialis Strategy: Why daily low-dose Cialis may work better than “as needed” dosing🧬 Mixing Peptides in One Syringe: What’s safe, what’s ideal, needle dulling, scar tissue risks, and when to switch to fresh pins🧊 Peptide Travel & Storage:** How long peptides can sit at room temp, when refrigeration matters, and what to look for in a reputable supplier😴 DSIP Dosing: Sub-Q protocol, realistic expectations (it doesn’t knock you out), and how it enhances REM sleep💆 Glow Serum vs Injectable GHK-Cu: Why topical formulations are different, post-laser healing benefits, and how often to apply⚖️ Low-Dose Naltrexone: When it may help cravings or receptor sensitivity and why it’s not a magic fix for everyone🧪 Thymalin & Adipotide: Why they’re less popular, safety concerns, and when thymosin alpha-1 is the better immune option🚴 Wolverine Stack Dosing: Daily maintenance vs blast protocols for athletes rehabbing injuries and staying ahead of inflammation🔥 RETA Stacking for Fat Loss: AOD, SLU-PP-332, 5-Amino-1MQ, and mitochondrial support for leaning out👴 65-Year-Old Starting TRT: Why 197 total test at that age is a strong candidate for replacement and why quality of life matters💧 Tesamorelin Water Retention in Women: Finding the sweet spot, dose adjustments, and why women often need much less💋 GHK-Cu After Microneedling: Why purpose-built serums beat injectable peptides used topically
💡 Hormones are individual. Bloodwork matters. Injection frequency matters. Ego from doctors doesn’t help. Your body is a science experiment learn it.
📌 Subscribe for weekly no-fluff education, protocols, and real-world results.
You’re a warrior. Act like one.

Become a supporter of this podcast: https://www.spreaker.com/podcast/peptide-of-the-week-weight-loss-health-wellness--7447107/support.

Medical Disclaimer: We are not doctors. The content in this video is for educational and informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease. Any compounds discussed may be intended for research purposes only. Use at your own risk.
Welcome back, warriors! In this episode of Peptide of the Week, JD Denham and William T. Haas break down one of the most misunderstood peptide categories out there: growth hormone secretagogues. From real GH to Tesamorelin to MK-677, this one is packed with nuance, strategy, and real-world results.
Chapters: 00:00 Welcome Back & Super Bowl Banter05:50 What This Episode Covers: Growth Hormone Secretagogues06:45 GHRH vs GHRP Explained (Simple Breakdown)12:50 Tesamorelin: Benefits, Fat Loss & Why It’s Top Tier15:30 CJC-1295 (With vs Without DAC)19:20 Age, Teens & Secretagogues (Who Should Not Use Them)23:30 MK-677: Hunger, Muscle Gain & When It Makes Sense26:50 Dosing Strategy, Timing & Cutting vs Bulking29:00 Tesamorelin & Sleep Issues (How to Fix It)34:30 Secretagogues vs Real HGH (What to Use & When)38:20 Long-Term Benefits: Recovery, Aging & Fat Loss41:20 TRT, Estrogen, AIs & What’s Coming Next44:10 Outro & Final Thoughts
We cover:🧬 GH Secretagogues 101: GHRH vs GHRP– GHRH (Tesamorelin, CJC) tells the pituitary to make GH– GHRP (Ipamorelin, MK-677, GHRP6) pushes the pulsing & release– Why you need both sides of the equation for max effect– Warehouse analogy explained: stock + shipping = full power
💉 Ranking the Peptides (Effectiveness vs Side Effects)– Tesamorelin: 5/5 effectiveness, 2/5 side effects the king of fat loss & GH synergy– Ipamorelin: Cleanest GHRP, low prolactin/cortisol risk– CJC-1295 (no DAC): Powerful GH increase, occasional histamine response– CJC w/ DAC: Long ester = higher blood levels but more estrogenic sides– MK-677: Strongest hunger, fullness, and muscle but water retention & fatigue are real– Hexarelin, GHRP6, GHRP2: Strong but outdated due to prolactin & side effects
📌 Side Effect Note:– CJC rash/histamine reaction? Try KPV or Benadryl or switch to Tessa– High prolactin? Avoid Hexarelin/GHRP6 or use Cabergoline as needed– MK too strong? Dose at night to sleep through the hunger
🔬 Secretagogue Strategy & Dosing Tips– Tesamorelin is FDA approved for reducing visceral fat not GH– MK-677 best dosed based on goal:– Bulking? Take AM to maximize food intake– Cutting or appetite control? Take PM to sleep through hunger– Pairing Tessa + MK = elite combo, but CJC might get suppressed by exogenous HGH
💡 Should Teens Use GH or Secretagogues?– Hard no on peptides for performance in high school– BPC/TB-500 for injuries? Yes.– But MK-677 or secretagogues to bulk? Not needed teens are already full of GH– “Let them eat more, train hard, and let nature do its thing.”
🧠 Bonus: Why Tesamorelin Might Affect Sleep– Some users report restlessness due to GH-induced sympathetic activity– Start low and titrate slowly (250mcg → 500mcg)– Stay the course: sides usually subside as body adapts
🔥 HGH vs Secretagogues– HGH = direct exogenous GH– Secretagogues = stimulate your own GH pulses– Take HGH in the morning (fasted) to avoid suppressing natural nighttime GH pulses– Never take HGH at night if you still want your body to produce on its own– Stack Tesamorelin + Ipamorelin at night = synergy– HGH + Tesamorelin = powerful belly fat & aging stack– HGH + CJC? Might suppress the CJC's value
📌 HGH Long-Term Benefits:– Fat loss, sleep quality, muscle retention, faster recovery, skin tightening, and aging in reverse– Plan: 1–2 IUs/day indefinitely– JD & Will both planning to run growth long-term– “This isn’t about youth. It’s about maximizing life.”
💬 Got questions or peptide topics you want broken down? Drop a comment below.
📺 Subscribe for more no-fluff, real science weekly.

Become a supporter of this podcast: https://www.spreaker.com/podcast/peptide-of-the-week-weight-loss-health-wellness--7447107/support.

Medical Disclaimer: We are not doctors. The content in this video is for educational and informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease. Any compounds discussed may be intended for research purposes only. Use at your own risk.
Welcome back, warriors. In Peptide Q&A Episode 27, JD Denham and William T. Haas dig into real questions from real people navigating fat loss stalls, hormone optimization, endurance training, peptide stacking, and long-term health. This episode is raw, conversational, and experience-driven exactly how these Q&As are meant to be.
We cover:
🔥 GLP Plateaus After Weight Loss: Why fat loss stalls after Tirzepatide or Semaglutide, how lost muscle slows metabolism, and when switching to RETA makes sense⚖️ RETA vs Tirzepatide Strategy: Dosing guidance, when to bump slowly, and how RETA helps preserve muscle while leaning out💪 Fat Loss Without the Gym: How bodyweight training, fasted movement, and protein timing matter when formal workouts aren’t realistic🧠 Secretagogues + RETA: Why running CJC/IPA or Tesamorelin alongside GLPs protects muscle and improves long-term body composition🔥 Cardio Myths & Fat Loss: Why steps don’t equal fat loss, why lifting beats cardio, and how muscle drives calorie burn even at rest🧬 HGH for Longevity & Body Recomp: Ideal dosing ranges (1–2 IU), why HGH is a long game, early side effects to expect, and realistic timelines🩸 TRT at a Young Age: When bloodwork matters more than age, why 32 isn’t always “too young,” and how lifestyle impacts testosterone⚠️ Estrogen Spikes on TRT: Symptoms of high estradiol, when to use an AI, why gyno risk is real, and how to find your personal sweet spot🧪 RETA Dosing for Lean Athletes: Why ultra-lean individuals often need lower, microdosed RETA instead of aggressive weekly dosing⚡ Energy & Focus Alternatives: Why peptides won’t replace Adderall, plus real-world discussion on Modafinil, CMAX, PE-22-28, and NAD🏃 Endurance & Hybrid Athletes: SLU-PP-332, mitochondrial peptides (MOTS-C, SS-31), Wolverine stack support, and muscle preservation for runners🦴 Injury Prevention for Runners: Why healing peptides and GH support matter when mileage is high and joints take a beating🧬 Tapering Off GLPs: Smart RETA tapering, appetite control during exit phases, and why Tesofensine or SLU can help bridge the gap🧪 Peptide Blends vs Individual Stacking: Real-world results with Wolverine and Glow blends, cost efficiency, and why “perfect pH” matters less in practice📏 Reconstitution Made Simple: Practical math for blends, vial strength breakdowns, and how JD & Will actually dose in the real world
💡 Peptides don’t replace discipline they amplify it. Diet, protein intake, sleep, hormones, and consistency still run the show.
👉 Drop your questions for the next Q&A.
📌 Subscribe for weekly Q&As, protocols, and real-world peptide education.
You’re a warrior. Act like one.

Become a supporter of this podcast: https://www.spreaker.com/podcast/peptide-of-the-week-weight-loss-health-wellness--7447107/support.

Medical Disclaimer: We are not doctors. The content in this video is for educational and informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease. Any compounds discussed may be intended for research purposes only. Use at your own risk.
Welcome back, warriors! In this special Peptide of the Week episode, JD Denham and William T. Haas are joined by Dr. Scott Collie a long-time friend and hormone optimization expert to take a deep dive into blood work, testosterone replacement, ester differences, side effects, and proper protocol stacking.
This one’s all about optimizing hormones with real strategy. If you’re considering TRT or already on it, this is required listening.
Chapters: 00:00 Welcome, New Studio & Guest Introduction03:00 Why Blood Work Matters Before TRT08:45 Estrogen, DHT & Detox Pathways Explained15:30 Alternatives to TRT (Clomiphene & Creams)17:00 What Testosterone Really Does in the Body22:20 TRT Dosing: Replacement vs Overdoing It28:00 Supplements & Peptides to Support TRT31:00 Testosterone Esters Explained (Cyp, Prop, Sustanon)41:00 Injection Frequency, PIP & Carrier Oils49:00 Diet, Fasting & Training Adjustments52:30 MOTS-C vs SS-31 (Mitochondria Explained)56:00 Intramuscular vs Sub-Q Peptides57:30 Testosterone Therapy for Women1:00:00 Final Thoughts & Wrap-Up
We cover:🩸 Blood Work & Baseline Panels– Why a comprehensive panel is essential before starting TRT or peptide therapy– Inflammation markers, homocysteine, iron levels & clotting risks– Common doctor mistakes: running only total testosterone with no free test or estrogen panels– Genetic factors (MTHFR), detox pathways & why gut health matters for estrogen clearance
💉 TRT Side Effects & How to Avoid Them– Estrogen conversion, DHT, prostate health & hair loss explained– Common side effects (acne, gyno, fatigue, mood swings) and how to minimize them– Methylation support: B6, B12, methyl folate, DIM, calcium glucarate– Natural blood thinners: fish oil, natto kinase, bergamot, turmeric
🧬 Ester Education – From Sipionate to Propionate to Sustanon– Fast vs slow release esters explained– When to choose Test Prop vs Sip vs Sustanon vs Enanthate vs Undecanoate– Daily vs weekly dosing strategies & injection protocols (IM vs SubQ)– What "PIP" (post-injection pain) means and how to reduce it (oil type, heating, MCT vs grapeseed)
🔥 Optimal TRT Dosing– Why 200–250mg is often too much for long-term use– Why 125–150mg/week is the true sweet spot for most men– Expected results timeline: 3 weeks to feel it, 6 weeks to retest, 3 months to dial it in– Monitoring lipid panels, hematocrit, ferritin, homocysteine over time
🧪 Stacking with Peptides– Using TB-500 and BPC-157 for injury recovery (yes, even for teens)– Thymosin Alpha-1 for immune support alongside TRT– When to avoid stacking GH secretagogues or MK-677 in younger athletes– Women & TRT: microdosing for libido, bone density, mood & anemia
💡 Bonus Topics– Intramuscular vs SubQ injection effectiveness– Mitochondrial repair: Why SS-31 should come before MOTS-C– Why some people feel NAD or MOTS-C — and others don’t (and why that’s okay)
📌 Bottom line: Hormone optimization isn't about blasting your body. It's about strategy, testing, and long-term health. From esters to estrogens, this episode cuts through the fluff with real talk and proven science.
🧪 This isn’t hype it’s hard data, real-world feedback, and first-hand experience.
💬 Got questions or peptide topics you want broken down? Drop a comment below.
📺 Subscribe for more no-fluff, real science weekly.

Become a supporter of this podcast: https://www.spreaker.com/podcast/peptide-of-the-week-weight-loss-health-wellness--7447107/support.

Medical Disclaimer: We are not doctors. The content in this video is for educational and informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease. Any compounds discussed may be intended for research purposes only. Use at your own risk.
Welcome back, warriors. In this week’s Peptide Q&A, JD Denham and William T. Haas break down a massive lineup of real-world questions covering everything from top peptide rankings and injury healing to fat loss for already-lean women, mitochondrial health, autoimmune conditions, and how to actually vet peptide vendors without getting burned. No rehearsed answers. Just experience, debate, and straight talk.
We cover:
🔥 Top 5 Peptides Explained: JD and Will rank their personal top peptides from the Wolverine stack and RETA to AOD-9604, HGH, IGF-1 LR3, MOTS-C, and NAD with real reasons behind each choice🧬 Switching Tesa/IPA to CJC/IPA: Why it’s okay to rotate secretagogues, how long to run each, and realistic dosing ranges for men vs women🏗️ IGF-1 LR3 Dosing & Cycling: How to properly titrate, why cycles should stay short (4–6 weeks), and what “too much” actually looks like🧪 Peptide Vendor Red Flags: COAs, missing endotoxin testing, reconstituted peptides, fake lab reports, and why “cheap” peptides are usually cheap for a reason⚠️ Endotoxins Explained: What acceptable levels really are, why most vendors don’t test for them, and how much risk actually exists in the real world🔥 Rapid Fat Loss & Liver Enzymes: Why fast weight loss can temporarily elevate ALT/AST, how GLP use plays into it, and why the liver usually rebounds💪 Fat Loss for Lean Women: Why RETA may not be ideal for already-lean females, better options like AOD + Tesamorelin, and when eating more fixes stalls⚡ Mitochondrial Stack Strategy: MOTS-C vs SS-31 whether to run together, timing logic, dosing ranges, and why consistency matters more than sequencing🦴 Severe Tendonitis & Injury Healing: Wolverine stack dosing strategies, loading phases vs long cycles, injection placement, and when to go aggressive🧠 Bulging Discs & Back Pain: Why peptides help inflammation but won’t fix structural disc issues and when surgery is the real solution🧑‍⚕️ Vitiligo & Autoimmune Support: Peptides that may help skin pigmentation and immune balance including BPC-157, GHK-Cu, KPV, Melanotan-1, and Thymosin Alpha-1💉 Glow Blend + Wolverine Together: How to stack BPC, TB-500, and GHK-Cu safely, daily vs weekly dosing, and copper limits😴 Sleep, Recovery & Budget Picks: Best one-to-two peptide choices when money is tight and long-term recovery matters
💡 Peptides aren’t magic but when dosing, sourcing, nutrition, and training line up, they’re powerful tools.
👉 Drop your questions for the next Q&A.
📌 Subscribe for weekly Q&As, deep dives, and real-world protocol breakdowns.
You’re a warrior. Act like one.

Become a supporter of this podcast: https://www.spreaker.com/podcast/peptide-of-the-week-weight-loss-health-wellness--7447107/support.

Medical Disclaimer: We are not doctors. The content in this video is for educational and informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease. Any compounds discussed may be intended for research purposes only. Use at your own risk.
Welcome back, warriors! In this powerhouse episode of Peptide of the Week, JD Denham and William T. Haas break down two of the most talked-about compounds in the game: AOD-9604, the fat-blasting fragment of HGH, and IGF-1 LR3, the muscle-building giant.
From deep dives into dosing and cycling to real-world protocols, stacks, and who should be taking what—this episode is packed with expert insight, personal anecdotes, and no-BS education for anyone trying to lose fat or build lean mass.
We cover:
🔥 AOD-9604 Breakdown– A synthetic fragment of HGH (amino acids 177–191) that’s purely fat-burning– No effect on IGF-1, insulin sensitivity, or muscle mass = ultra-targeted shredder– Great for men and women, especially those coming off GLP-1s like Retatrutide– Best stacked with: Retatrutide, SLU, 5-Amino-1MQ, or L-Carnitine– Typical dose: 250–500mcg, 1–2x/day– Cycle: 12–16 weeks, then rotate to another fat burner
💪 IGF-1 LR3 Deep Dive– Long-acting form of IGF-1 (stays active for 20–30 hours)– Directly signals lean muscle growth, nutrient partitioning, and recovery– Bypasses pituitary, HGH, and liver—delivers pure muscle-building power– Works best when paired with heavy training volume and carbs (not for keto)– Use post-workout, pre-big meals, or pre-workout for massive pumps– Dose: Start at 20mcg/day, ramp to 60–80mcg max. Run for 4–6 weeks max– Expect: Fuller muscles, faster recovery, and nutrient super-absorption
🧪 Stacking Strategies for Fat Loss & Muscle Growth– Best Cutting Stack (Men/Women): Retatrutide + AOD + SLU + L-Carnitine– Best Muscle Growth Stack: TRT + IGF-1 LR3 + Protein + Carbs + Volume Training– Maintenance/Transition: Swap from GLP-1 to AOD for ongoing fat metabolism– Advanced Users: Add Tesamorelin, MK-677, or GH Secretagogues depending on goals– Cycle Recommendation: AOD (16 weeks), IGF-1 LR3 (4–6 weeks), then rotate
💡 Tips & Warnings– IGF-1 LR3 requires high protein intake + carbs to be effective– Not ideal on a strict keto or fasting protocol– AOD is not stimulatory, very safe, and can be used long term– Do not inject AOD if it gels—reconstitute with proper AOD water or acetic solution– Avoid stacking GLP-1s together, but you can stack everything else
🧠 Big Takeaways– Peptides are optimizers, not miracle workers– Fat burners only shine when paired with workouts and clean eating– IGF-1 LR3 = closest peptide to a steroid effect, but safer and leaner– If you're looking to shred fat or pack on lean muscle, these two are top-tier
Chapters00:00 Intro00:18 Hat mix-up + sick talk04:02 Episode topic: HGH family peptides overview05:20 AOD-9604 explained (fat loss only)11:06 HGH vs Secretagogues vs IGF-1 (key differences)18:40 HGH timing + safety/cancer talk25:19 AOD dosing + how long to run it28:02 AOD mixing/gelling problem + fix34:49 IGF-1 LR3 explained (muscle growth peptide)38:10 Best ways to use IGF-1 (post-workout / carbs / cheat meal)46:11 IGF-1 dosing basics + final recommendations49:09 Outro
⚔️ Drop your questions in the comments. JD and Will read every DM.
🎥 Subscribe for more real-talk, no-hype breakdowns. Q&A episode drops later this week.

Become a supporter of this podcast: https://www.spreaker.com/podcast/peptide-of-the-week-weight-loss-health-wellness--7447107/support.

Medical Disclaimer: We are not doctors. The content in this video is for educational and informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease. Any compounds discussed may be intended for research purposes only. Use at your own risk.
Welcome back, warriors! In this week’s Peptide Q&A, JD Denham and William T. Haas dive into another real-world round of questions from mixing protocols and fat loss stacks to bulking strategies, side effects, and safety-first decisions. No theory. Just what they’ve seen, tested, and learned the hard way.
We cover:
💉 Mixing Multiple Peptides in One Shot: How JD combines multiple peptides into one sterile vial to avoid 5 separate jabs and why glutathione should stay separate🧪 Cloudy Syringe Warning Sign: What it means when a mix turns cloudy and when that’s your sign to stop combining certain compounds🧠 pH Balance Debate: JD shares what a trusted source in the peptide world told him about mixing and why he doesn’t stress the “internet experts”🍽️ Bulking on RETA + AOD: Can you gain muscle while using fat-loss peptides? Yes but only if you’re eating in a true surplus🔥 RETA Killing Appetite While Bulking: How to push calories even when you’re full fast and why “eat past full” becomes the real skill⚙️ Osteoporosis Stack for Mom: Tesamorelin + Ipamorelin dosing for older women, why lower doses matter, and why bedtime shots amplify results🧬 Adding HGH for Bone Health: Why JD likes low-dose HGH for anyone over 40, and how it stacks alongside Tessa/IPA👕 Warrior Makers Tank Tops: What’s coming soon, why the last cutoffs were way too long, and what brands they actually like🚫 Benign Tumor + Peptides: Why both JD and Will say to cut peptides completely when tumor growth is involved even “health boosting” ones like NAD and MOTS-C🔥 CJC/IPA or Tessa/IPA + AOD Together: Why these stack clean with zero overlap, and why AOD stays one of JD’s top fat burners📩 Provider Questions: How to DM Warrior Makers or JD Fit to get pointed in the right direction🟥 Red Welts from MOTS-C + GHK-Cu: Why it might be an allergic reaction, injection depth issues, or sensitivity plus KPV/antihistamine suggestions🥵 GHK-Cu Sting Fix: The “no sting water” solution that makes GHK-Cu tolerable (and what to realistically expect)❄️ Should You Freeze RETA? Hard no why cold + dry + dark storage wins, and why freezing isn’t the move for home use🏋️ Best Peptides for Bulking: IGF-1 LR3 post-workout, MK-677 for hunger, and the truth: peptides don’t replace food📏 IU vs Units Confusion: Why “20 IU” isn’t the same thing as “20 units,” and why water volume changes everything🔥 How Long to Run AOD: Why JD runs it long-term, and why Will suggests cycling off if the body adapts💓 Increased Heart Rate on Tessa/IPA:** Water retention, blood pressure, and why titrating up slowly is the smartest way to restart🧠 Anti-Aging Stack for Overstimulated Women:** Low-dose NAD, GHK-Cu, and low-dose HGH keeping results without overstimulation
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Medical Disclaimer: We are not doctors. The content in this video is for educational and informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease. Any compounds discussed may be intended for research purposes only. Use at your own risk.
Welcome back, warriors! In this episode of Peptide of the Week, JD Denham and William T. Haas break down one of the most exciting performance enhancers in the peptide-adjacent world SLU-PP-332. It’s not technically a peptide, but it gets lumped in for a reason.
From fat metabolism to increased cardio endurance to insane nutrient partitioning this compound mimics exercise at the cellular level. Whether you're an elite athlete or just trying to drop fat and feel better, this one's worth a look.
We cover:
🔥 What is SLU-PP-332?– Classified as an exercise mimetic your muscles behave as if you're training, even at rest– Increases endurance and fat oxidation while preserving glucose stores– Revs up the mitochondria your cells’ power plants to generate clean energy– Works within 4–6 hours of dosing, ideal for 2–3x daily use– Comes in injectable, oral, and sublingual forms (we’ve tried them all)
💊 Forms & Favorite Dosing Protocols– Sublingual: ideal for daily use (1mg 3x/day = sweet spot for most gym-goers)– Injectable: JD and Will both prefer this form for higher-dose benefits– Study-based doses range from 250mcg/day to experimental 50mg/day protocols– Current consensus: 1–2mg 2–3x/day = powerful and sustainable– JD’s protocol: sublingual at desk AM/midday/PM Will’s dose: 2mg injectable pre-work
⚙️ Stacking Benefits & Combos– Fat Loss: Sloop + AOD-9604 + Retatrutide + Tesamorelin– Endurance/Performance: Sloop + L-Carnitine + Mots-C + DSIP for recovery– Gut & Recovery: Stack with KPV, BPC-157, TB-500 + GHK-Cu (aka the Wolverine stack)– Energy + Mitochondria Health: Add NAD or Mots-C for deep mitochondrial support– For women or entry-level users: sublingual is a great, safe gateway protocol
🧠 What It’s NOT– Not a stimulant. No heart rate spike, no crash, no adrenal stress– Works by enhancing energy efficiency, not by jacking up your system like clenbuterol– Allows for fat burning during rest or sleep without harming recovery or muscle tissue
⚠️ Notes on Sloop + BAM Mix– Popular hybrid: 250mcg Sloop + 50mg BAM burns fat via dual mitochondrial mechanisms– JD recommends adding 1000mcg more Sloop if using combo products for enhanced burn– Not WADA-approved athletes should check clearance
📆 Protocol Summary:– Beginner dose: 250–500mcg 3x/day– Advanced use: 1–2mg 2–3x/day (injectable or sublingual)– Cycle: Run 6–12 weeks, then rotate or stack with Mots-C or NAD– Perfect stack (JD’s pick): AOD AM, Sloop 3x/day, Retatrutide 3x/week, Tesamorelin PM, DSIP for sleep– Will’s pick: Testosterone base + Ipamorelin/CJC + Sloop + Wolverine stack (BPC + TB + GHK-Cu)
💬 Curious about mixing this with your current peptide plan? Drop questions in the comments we read every single one.
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