Ayahuasca Podcast with Sam Believ

Placebo, open science and microdosing with Rotem Petranker

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In this episode of Ayahuasca Podcast host Sam Believ (founder of www.lawayra.com) has a conversation with Dr. Rotem Petranker, Associate Director of the Psychedelic Studies Research Program at the University of Toronto, co-founder of the Canadian Centre for Psychedelic Science, and a postdoctoral fellow at McMaster University. His work focuses on microdosing, attention, emotional regulation, and open science.

We touch upon topics of:

  • [00:01:00] Rotem’s background and early path into psychedelic research
  • [00:02:00] Why microdosing research began and early challenges
  • [00:03:00] Perspectives on drug policy, legalization, and mental health
  • [00:05:00] Design of Rotem’s psilocybin microdosing clinical trial
  • [00:07:00] Study outcomes, placebo response, and limitations of once-a-week dosing
  • [00:11:00] Diversity of participants and feasibility for future research
  • [00:12:00] The role of set, setting, and the “social matrix” in healing
  • [00:14:00] Group dynamics, contact high, and integration at retreats
  • [00:16:00] The challenge of reductionist science versus indigenous traditions
  • [00:21:00] Replication crisis in psychology and the need for open science
  • [00:23:00] Pre-registration, open data, and transparency in psychedelic research
  • [00:35:00] Different epistemologies: indigenous wisdom vs. neuroscience
  • [00:37:00] Comparing LSD and psilocybin microdosing (duration, variability, safety)
  • [00:39:00] Benefits and drawbacks of microdosing—mood, anxiety, sleep
  • [00:42:00] Microdosing vs. antidepressants and side effect profiles
  • [00:45:00] Bro-science explanation of SSRIs vs. psilocybin and how little we know
  • [00:47:00] Why open science matters and how to evaluate credible research

    • If you would like to attend one of our Ayahuasca retreats go to www.lawayra.com

    Find more about Dr. Rotem Petranker at @rpetranker and through the Canadian Centre for Psychedelic Science.

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    Ayahuasca Podcast with Sam BelievBy Sam Believ
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