Podcast Notes Playlist: Latest Episodes

• We’re barely scratching the surface of how autophagy impacts metabolism
• Context of autophagy is very important – autophagy protects person from getting cancer but once someone has cancer it appears autophagy benefits cancer cell instead of healthy cells
• Fasting is one of the most potent stimulators of autophagy
• We have a critical need to study and identify the proper dose of fasting to improve human health
•  “The key to living longer is delaying the onset of chronic disease…not living longer with the chronic disease” – Dr. Peter Attia
• “Fasting is probably protective against all chronic diseases.” – Dr. Peter Attia

In this episode, Eileen White, Chief Scientific Officer at the Rutgers Cancer Institute, describes the fundamental role of autophagy in the maintenance of health and prevention of neurodegeneration, cancer, and other diseases. She also goes into detail about the paradoxical finding that autophagy may benefit an existing cancer cell and help it to survive—a discovery leading to new possibilities in cancer therapy. We also discuss fasting (and molecules that induce autophagy) and the critical need to decode the proper fasting “dose” in order to improve human health.

We discuss:

• Eileen’s discovery that a specific oncogene blocks apoptosis [3:40];
• Defining apoptosis and its role in cancer prevention [10:00];
• How cancer cells use the autophagy pathway to survive [17:20];
• Stressors that induce autophagy [29:15];
• The importance of autophagy in the brain and liver [32:45];
• The mechanisms that can trigger autophagy to support longevity [40:00];
• Evidence for cancer treatment by blocking autophagy [42:30];
• Types of cancer that are most autophagy-dependent [46:45];
• The autophagy paradox [52:40];
• Finding a molecular signal for autophagy [59:15];
• Current knowledge gaps around fasting as a tool for longevity [1:13:00];
• Rapamycin, metformin, and other molecules that may induce autophagy [1:22:15];
• How to study fasting and exercise as longevity tools [1:32:50];
• The Nobel Prize for autophagy research [1:36:45];
• Eileen’s future areas of research [1:38:25];
• A fasting strategy for Alzheimer’s Disease prevention[1:49:25];
• Future study of metabolism and autophagy [1:51:30]; and
• More. 

Learn more: https://peterattiamd.com/

Show notes page for this episode: https://peterattiamd.com/eileenwhite 

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This episode features Naval Ravikant’s profile from Tools of Titans, which is now available as an audiobook. This chapter's narrators are Kaleo Griffith (bio) and Ray Porter (profile). To check out the full audiobook of Tools of Titans with 100+ chapters, visit audible.com/ferriss.

The audiobooks of Tools of Titans and Tribe of Mentors can be found at audible.com/ferriss

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• Lack of stability and mobility can hinder progress in squat
• Free weights are superior to machines available at big box gyms
• In the long run, compound movements have a bigger payoff than isolation movements
• False grip might feel more comfortable but is can be more dangerous for certain lifts and can negatively alter recruitment patterns
• Maintaining good gut motility is the number one priority for overall gut health

• Who would have thought Tiger King was the most normal thing in 2020. (4:11)
• Mind Pump are BIG bird guys. (5:55)
• Mind Pump Workouts. (8:18)
• The Stock Market doesn’t make sense. (10:05)
• Gun sales are through the roof amid the coronavirus pandemic. (11:54)
• Pregnancy and parenting. (16:13)
• Magic Spoon’s new formulation. (28:32)
• THC, terpenes, and pain management. (30:40)
• Good vs bad people. (37:35)
• #Quah question #1 – Why do I struggle to put weight on my squat? I am a long, lanky build and I have tried many stances and cannot break 300. (43:17)
• #Quah question #2 – As someone who has gone to a big-box gym for years, I have struggled during this quarantine. I am used to doing way too many isolation movements, but at present only have a barbell, weights, and a squat rack. Can I solely use this equipment and still make progress by focusing just on compound movements? (48:42)
• #Quah question #3 – What is your opinion on false grip vs standard grip while overhead pressing or barbell benching. I feel as though I have more strength using a false grip. (54:43)
• #Quah question #4 – What are your best tips for gut health? (58:46)

Related Links/Products Mentioned

• June Promotion: MAPS HIIT ½ off! **Promo code “HIIT50” at checkout**
• Carol Baskin Wins Joe Exotic's Tiger King Zoo in New Court Ruling
• RETAILERS REPORT THAT 40% OF THEIR CUSTOMERS ARE FIRST-TIME GUN OWNERS DURING COVID-19
• Gun sales surge 80% in May, says research firm
• What Representing Men in Divorce Taught Me About Fatherhood | Marilyn York | TEDxUniversityofNevada
• Visit Magic Spoon for an exclusive offer for Mind Pump listeners!
• Researcher receives $3.9 million grant to study how cannabis chemicals can help with pain
• Mind Pump #780: Delivering Health & Happiness With Dosist
• Visit PRx Performance for an exclusive offer for Mind Pump listeners! **Code “mindpump” at checkout**
• What is Gut Health – Mind Pump Blog
• Intuitive Nutrition Guide ½ off! **Code “FOOD50” at checkout**
• Mind Pump Free Resources

People Mentioned

Max Lugavere (@maxlugavere)  Instagram

• Although the carnivore diet has been great for Shawn, he says that not everyone will see the same effect from going on the diet. Different people need different foods.
  • “I don’t think fruits and vegetables are inherently bad…I just think some people tolerate them better than others” – Shawn Baker
• So what should people be eating exactly? We don’t know.
  • “This is a hard thing. Nutrition is extremely hard.” – Shawn Baker
• When it comes to foods that cause allergies, red meat is almost always on the bottom of the list
  • “Red meat seems to be like that safe baseline food” – Shawn Baker
    • Start with only eating red meat, and then slowly add different foods one at a time to see how your body reacts
• If you there’s a health problem that’s bothering you, don’t look at the carnivore diet as a last resort, try it early
  • “I think it’s something we should do early. If it works, great. If it doesn’t work, give it 90 days. It doesn’t work? Fine, we’ll move on to something else but I think it should be an early intervention for a lot of conditions.”  – Shawn Baker
    • The carnivore diet has shown to be helpful for people with an autoimmune disease, crohn’s disease, mood disorders, and other health issues
• Shawn argues that if everyone went vegan, people would be nutrient deficient in lysine, zinc, and other nutrients. People would also have to eat more calories to get the same amount of nutrition from animal meat
  • “People would be nutrient deficient, they’d be eating more calories, they’d be fatter than they are now. We wouldn’t be saving the planet.” – Shawn Baker
• When it comes to greenhouse gases, the healthcare system produces 10% of our greenhouse gases while cows only produce 2%. 
  • “So what’s non-sustainable is sick people…Sick people are the biggest environmental impact when it comes to greenhouse gases.” – Shawn Baker
• “It’s really hard to get fat eating meat” – Shawn Baker
  • “Meat is the most satiating diet you’re going to find…protein is the most satiating macronutrient” –  Max Lugavere

Shawn Baker, MD is a board certified orthopedic surgeon, multi-sport world record holding Masters 50+ Athlete, and the author of The Carnivore Diet.

• The smartphone is the true personal computer:
  • “You have this device with you that has a large enough screen to do work done is small enough to be pocketable” – Ben Thompson
    • Expect to see more  specialized devices like AR glasses and smartwatch in the future, but the smartphone will still be the main device people use
• What makes a company an aggregator:
  • Has relationships with users
  • Zero marginal cost of serving users
  • Decreasing acquisition costs over time
• Spotify’s master plan to take over the podcast space:
  • “They’ll say, look, we have all these customers, we monetize better because we understand these customers better. You need to come onto our platform and use our superior, we will monetize you better. And then suddenly they become the center of this where they have a critical mass of users who they understand better and they pull podcasters on and start getting this sort of a virtuous cycle and becomes sort of the center of podcasting.” – Ben Thompson
• Apple had the opportunity to do this but they passed on it: 
  • “ iTunes doesn’t host podcasts. A lot of people don’t realize this, but it’s sort of the directory where everything is and the more important thing is the Apple podcast player is the biggest podcast player. Had Apple chosen to leverage that particularly a couple of years ago, they could have built this whole thing, built an ad network, but…it’s just not what Apple sort of does and so they sort of just let it be” – Ben Thompson
• Disney is able to charge a lower subscription fee for their service than Netflix because Disney can monetize their customers in more ways than Netflix (ex: cruise lines, amusement parks, etc.)
• Ben is bullish on local journalism but only if they report on important local events instead of constantly posting non-essential articles
  • “I don’t need more content. What I’m looking is to feel informed and you deliver the experience of feeling informed oftentimes by telling someone nothing here, go spend your time somewhere else and you’ve actually checked that.”– Ben Thompson

My guest today is Ben Thompson. Ben is the author of my favorite business strategy newsletter called Stratechery. He’s also the host of the exponent podcast, and now the Dithering, a podcast he recently launched with John Gruber. I think Ben is among the most interesting business analysts in the world, and I’ve learned from and directly applied many of his ideas. We cover many of the major concepts he’s introduced over the years, including his well know aggregation theory. I think that to understand how the internet has changed the business world for good, you must read Ben and follow his thinking. I’m excited to finally have him as a guest on the show. Please enjoy our conversation.

For more episodes go to InvestorFieldGuide.com/podcast.

Sign up for the book club, where you’ll get a full investor curriculum and then 3-4 suggestions every month at InvestorFieldGuide.com/bookclub.

Follow Patrick on Twitter at @patrick_oshag

Show Notes

(01:26) – (First question) – Companies that are built for the next disruption

            (1:32) – The End of the Beginning

(9:58) – Aggregation Theory and the Smiling Curve

(13:18) – Steps to creating an aggregator

(19:46) – Pattern of successful aggregators or luck?

(24:34) – How aggregators interact with suppliers and consumers

(30:49) – Taking on other aggregators

(34:09) – Platform vs aggregator in the scope of Shopify vs Amazon/Walmart

(40:55) – The Moat Map

(46:16) – Value chain thinking and profitable business models

(51:58) – Future of media and independent content creator’s vs bundles

(56:07) – Bundling independent creators

(1:00:37) – The infrastructure layer of technology and software companies

(1:02:35) – His thoughts on gaming platforms

(1:06:13) – The atoms vs the bits in the tech world

(1:12:18) – What he’s learned from covering Netflix

(1:13:46) – Kindest thing anyone has done for Ben

            (1:15:56) – Stratechery Podcast

Learn More

For more episodes go to InvestorFieldGuide.com/podcast. 

Sign up for the book club, where you’ll get a full investor curriculum and then 3-4 suggestions every month at InvestorFieldGuide.com/bookclub

Follow Patrick on Twitter at @patrick_oshag

• Often the ‘Crutch’ that you lean on will become a leash that holds you back or hurts you or your business
  • “The only way to fix dependence on a crutch is to let it go and start walking without it” – Roland Frasier
• The 5 steps to getting rid of your crutches:
  • Inquire
  • Identify
  • Visualize
  • Prepare
  • Act, Throw, and Cut
• The reason crutches are hard to remove is that they helped us once
  • Ending a relationship, whether with drugs, alcohol, a person, or a crutch, is one of the hardest things we as humans may have to do
    • Prepare yourself for this: For each item or person, you need to let go of, write out what you want to say and rehearse the conversation in your head

Today Roland tells a story that demonstrates a timeless principle in business and life. If you want to move forward faster in your personal or business life, this episode will certainly help you do just that.

"The only way to fix dependence on a crutch is to let go and start walking without it." Roland Frasier

Often the 'Crutch' that you lean on will become a leash that holds you back or hurts you or your business. If this rings true for you, listen in today for Roland's Step by Step plan for throwing away YOUR crutches and leashes. Be sure to hit SUBSCRIBE on Apple Podcasts and share this episode with your business-minded friends.

  • What things are you doing in your life and business that you don't want to do?

  • Identify the tasks that you hate, that you loathe?

  • What are you doing that's not earning you the money you need to live the life that you want to lead?

  • Who is someone you work for, or with, that no longer brings joy or value to your personal life or business?

  • Is there anyone in your business or life that you don't see eye-to-eye with on moral or ethical issues? Who has values that don't match your own, and they're not likely to any time soon?

Make a list of all of the above.

Make a list of things to stop doing and relationships to end, based on your answers to the questions above. When you've done this, you now have a list of all of the crutches that have become leashes. 

If you are going to take these necessary actions, you're going to need some help getting motivated. 

Take a moment to imagine life in a year, when you've eliminated each crutch/leash on your list. Picture how much more profitable, peaceful, joyful, your life will be. Behavioral Scientists call this ‘future pacing’. Now hold onto this visualization as you move on to step 4.

As humans, we are all conditioned to avoid pain and seek pleasure. The reason these crutches are hard to let go of is that at some point, they helped. At some point, they were beneficial. Ending a relationship, whether with drugs, alcohol, a person, or a crutch, is one of the hardest things we as humans may have to do. 

Prepare yourself for this. For each item or person, you need to let go of, write out what you want to say ...Even if you have to play devil's advocate with Yourself and do some self-talk! Listen to the episode for Roland's examples.

Accelerate your happiness and success by using this process and take some giant leaps forward, on your own two feet. Lean on the work you've done and do what you need to do. 

Now that you're thinking consciously and intentionally about recognizing these crutch and leash situations, you will be able to move forward faster into the life you want to live.

Roland practiced business, tax, and securities law for over 12 years and is now an active investor who drives growth and scale in his portfolio companies. He is co-founder and/or principal of three current Inc. Magazine fastest-growing companies and he has founded, scaled, or sold 24 different 7 to 9 figure businesses ranging from consumer products to industrial machine manufacturing companies with adjusted sales ranging from $3 million to $337 million. Roland is currently growing DigitalMarketer.com, RivalBrands.com, and Plattr.com while advising over 150 other companies on digitally centric customer acquisition, activation, referral, retention, and revenue strategies and plan implementation.

Click to find us on Apple Podcasts and other podcast players.

The dystopia is here.

Chaos, confusion, fear and anger. Horrific racism. Generations of pain fueling rioting and violence. Death and illness. Faltering systems and leadership failures. Market crashes and jobs lost.

Communities are divided. Home lives are disrupted. Meanwhile, cities all across America are literally on fire.

How we can right the ship? Deal with these cataclysmic shifts? And move forward productively?

We can crash and burn. Or we can adapt -- a remaking of society that begins with personal reinvention.

James Altucher is a virtuoso of this process.

A prodigious intellect and abundantly talented polymath, James is a comic, chess master, entrepreneur, investor and prolific writer with over twenty books to his name, including the Wall Street Journal bestseller Choose Yourself. He's also a fellow podcaster and an unconventional thinker with an idiosyncratic lens on pretty much everything from creativity to finances.

James and his writing have appeared in major media outlets including The Wall Street Journal, The New York Times, The New York Observer, Techcrunch, and The Financial Times. His blog, JamesAltucher.com, has attracted more than 20 million readers since its launch in 2010. And The James Altucher Show ⁠regularly appears in the top 100 podcasts on iTunes.

On the subject of self-experimentation, James' latest unconventional move was releasing his latest self-published book, Think Like a Billionaire, on Scribd.

Most compelling is James' relentless devotion to constant reinvention. Making his fourth appearance on the podcast, today we explore the importance of this trait ⁠and the habits that enable you to adapt and thrive in rapidly changing times ⁠— more critical now than ever.

Recorded pre-pandemic in mid-February, this conversation is the last in my stash of episodes banked before quarantine.

Nonetheless, I suspect you will find our discourse highly applicable to our current moment -- packed with tactics and strategies you can deploy to better acclimate to the rapidly changing circumstances that face us all.

It's about how to make better decisions. And ultimately, how to create opportunity out of calamity.

The visually inclined can watch it all go down on YouTube. And as always, the audio version streams wild and free on Apple Podcasts and Spotify.

James is one of my most favorite people. He’s a natural and gifted conversationalist, his ideas are easily deciphered, and packed with the perfect amount of humor and data-backed insight.

To some degree, we are all being called to reinvent ourselves right now. May this conversation help serve that process.

Peace + Plants,

Listen, Watch & Subscribe

Apple Podcasts | YouTube | Spotify | Stitcher | Google Podcasts

Thanks to this week’s sponsors

Four Sigmatic: Nutritious and delicious mushroom brews and elixirs made with only the highest quality adaptogens and easy to take on the go. To try ‘em out visit foursigmatic.com/roll and use the discount code ROLL to get 15% off ALL PURCHASES.

Outerknown: Founded by pro-surfer Kelly Slater, Outerknown creates high quality, sustainably produced, and great looking men’s and women’s clothes, ethically manufactured in the world’s cleanest solar-powered factory. When you’re ready to amp up your wardrobe with awesome sustainable duds, go to outerknown.com and enter my code RichRoll at checkout to get 25% off your full-price order.

Whoop: The world’s most powerful fitness tracker. Get smarter about how you sleep, recover, and train, so you can unlock your best self. Go to WHOOP.com and use the promo code “Richroll” at checkout to save 15% off your order.

Note: One of the best ways to support the podcast is to support the sponsors. For a complete list of all RRP sponsors and their respective vanity url's and discount codes, visit my Resources page and click "Sponsors".

SHOW NOTES

• Connect With James: Blog | Facebook | Twitter |Instagram
• Podcast: The James Altucher Show
• Book: Think Like A Billionaire
• James' Other Books: James Altucher on Amazon
• TEDxSanDiego: Choose Yourself with James Altucher
• The New York Times: Why Self-Help Guru James Altucher Only Owns 15 Things
• Forbes: James Altucher: The Most Interesting Man In The World
• The Street: Bitcoin at $1 Million Is Not Out of the Question, Says James Altucher
• Influencive: What You Should Talk About When You Talk About Money
• CNBC: James Altucher’s 10 predictions about where bitcoin and cryptocurrencies are headed
• CNBC: Cryptocurrencies will replace ‘some or all’ paper money, investor James Altucher says
• Forbes: James Altucher: Now Is The Best Time To Be An Entrepreneur
• Observer: The Six Things the Most Productive People Do Every Day
• TechCrunch: Articles by James Altucher
• Huff Post: Articles by James Altucher

Related Podcasts You Might Enjoy

• RRP 75: James Altucher on Why You Should Choose Yourself
• RRP 347: James Altucher on The Art of Thinking Differently 
• The James Altucher Show: Rich Roll – Stop Killing Yourself

Thanks to Jason Camiolo for production, audio engineering and show notes; Margo Lubin and Blake Curtis for video, editing and graphics; portraits by Ali Rogers; copywriting by Georgia Whaley; and theme music by Hari Mathis, Tyler Piatt & Trapper Piatt.

*Disclosure: Books and products denoted with an asterisk are hyperlinked to an affiliate program. We are a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for us to earn fees by linking to Amazon.com and affiliated sites.

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Support The Sponsors: One of the best ways to support the podcast is to support our sponsors. For a complete list of all RRP sponsors and their respective vanity url's and discount codes, visit my Resources page and click "Sponsors".

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