Podcast Notes Playlist: Latest Episodes

By Podcast NotesBusiness Entrepreneurship Health & Fitness

Podcast Notes Playlist: Latest Episodes episodes

January 16, 2024 Crisis in Higher Ed & Why Universities Still Matter with Marc & Ben
In this one-on-one conversation, Marc and Ben tackle the university system – what has certainly been a hot topic that’s been dominating the news over the past few months. As Marc states at the top of the episode, universities matter tremendously to our world, but they’re currently in a state of crisis.
Together, Ben and Marc take a “structural” look at higher education, delving deep into the twelve functions of the modern university. They also unpack the numerous challenges that universities face today – student debt and the replication crisis, among them.
They also discuss topics including DEI, student athlete admissions, accreditation, inflation, and much more.
As colleges face an existential threat that could have long lasting repercussions, how can we find ways to improve these institutions, while being open to new entrepreneurial opportunities in education?
1 hr 49 min
January 11, 2024 What to Expect in 2024: Predictions from Niall Ferguson, Tyler Cowen, Peter Attia, John McWhorter and More
Last year was certainly eventful. 2023 brought spy balloons, Donald Trump’s indictments, the coronation of a king, the fall of a crypto prince, and no shortage of chaos in Washington, from the ousting of Kevin McCarthy to the farcical George Santos scandal. Oh and then there’s the small matter of two major wars, one in Gaza and one in Ukraine. Plus, ongoing tension between the U.S. and China. On a cheerier note, 2023 was also the year of Barbenheimer, the year when it felt like AI really arrived, and the year when the 90s were finally cool again.
But, as crazy as last year was, will the next twelve months prove that it was actually just the calm before the storm?
For many of us, 2024 begins with a distinct feeling of dread.
The Middle East grows increasingly unstable, the war in Ukraine is not going Kyiv’s way, and Xi Jinping’s rhetoric gets more bellicose by the day. Here at home, there’s the small matter of the election from hell, in which American voters face the unappetizing prospect of once again having to choose between Donald Trump and Joe Biden.
To try and figure out whether things will really be as terrible as we fear, today on Honestly Bari Weiss and FP editor Olly Wiseman are calling up some of our favorite experts to get a better sense of what’s coming down the pike.
The great Tyler Cowen looks into the economic crystal ball. Leandra Medine clues us in on fashion trends in 2024. Our very own Suzy Weiss talks through the cultural year ahead. Linguist John McWhorter looks at language. Doctor and longevity expert Peter Attia tells how to start the year healthy. Eagle-eyed political observers Nate Silver and Frank Luntz try to forecast the election. And the historian Niall Ferguson tells us whether we’re right to be having nightmares about World War III.
Some guests cheered us up, others freaked us out. All of them were a pleasure to talk to. Welcome to 2024!
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1 hr 50 min
January 11, 2024 #441: Mike Posner – The Journey Back Home
Mike Posner is the light.
He's known worldwide as a Grammy-nominated musician. His songs like "I Took A Pill In Ibiza" and "Cooler Than Me" have been streamed billions of times.
But really, he's so much more than that.
His music helped pull me out of depression. His album – Keep Going – changed the trajectory of my life. Mike was the person I listened in September 2019 (when I started meditating and did 75 Hard).
I noticed there was something different about how he operated. He was acting in love. He was self-aware. He was willing to work hard but also trusted the flow of life. I didn't know what he was on, but I wanted it.
His impact on my life has been incredible. And then to sit down with him for 2+ hours... and have it go better than I could imagine?
What a dream come true.
0:00 Thank You, Mike
3:14 The Blessing
4:40 Channeling The Divine
10:10 The Deeper The Human, The Deeper The Song
14:57 Moments Of Being
18:00 Big Sean’s Influence On Mike
25:03 “None Of These Teachers Are More Profound Than Life Itself”
30:00 Crazy Synchronicity (If I Pray For You, What You Prayed For?)
35:35 How To Feel More Synchronicities? (Acknowledge, Accept, Appreciate, Affection, Allow)
42:10 What Were Mike Posner’s Biggest Insecurities?
46:01 A Belief Is A Thought Repeated
50:14 How To Be The Light
1:01:12 Nonviolent Communication
1:08:01 Our Purpose
1:17:19 “I Am Not Mike Posner”
1:20:09 How Has Becoming A Musician Made Mike Better?
1:23:11 Suffering As An Artist
1:26:31 Walking Across America
1:41:39 What Is Death?
1:46:01 Relationship With Father
1:57:13 Relationship With Mother
2:01:14 How To Heal Close Relationships
2:08:01 Idolization + Pedestalization
2:13:32 What Does Mike Value Most?
2:15:02 Challenge
Follow Mike on Instagram: https://www.instagram.com/mikeposner
My Twitter: https://twitter.com/heydannymiranda
2 hr 18 min
January 11, 2024#185 Blake Eastman: Learn to Read Anyone
Knowledge Project
Key Takeaways
Check out the Knowledge Project Podcast Episode Page & Show Notes

Read the full notes @ podcastnotes.org

Blake Eastman has dedicated his entire life to psychology and nonverbal behavior. In 2009 he founded The Nonverbal Group, a behavioral research and education company in New York City which conducts large scale studies on human behavior and uses a wide range of technologies to systematically deconstruct and improve human communication. Eastman dives deep into how we communicate with one another, including the ability to read nonverbal cues, his thoughts on big talkers vs. silent types, how we can communicate with our partners without complaining, the value of watching ourselves communicate on video, understanding the power structures and social dynamics at work, and so much more. Eastman has also served as an adjunct psychology professor at the City University of New York for six years where he taught General Psychology, Developmental Psychology, and Group Dynamics. He is also a former professional poker player and the founder of School of Cards, the first brick-and-mortar poker school in New York City. Listen and Learn
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Watch the episodes on YouTube: https://www.youtube.com/c/theknowledgeproject/videos

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1 hr 40 min
January 06, 2024#085 Dr. Peter Attia on Mastering Longevity – Insights on Cancer Prevention, Heart Disease, and Aging
Found My Fitness - Rhonda Patrick
Key Takeaways
“The healthier an individual is, the more they can rely on their mitochondria for ATP generation under increasing demands of the cell. This is one of the hallmarks of health.” – Dr. Peter Attia
Spend good time training in Zone 2; this means a rate you can hold a conversation and form sentences at, but really don’t want to
For many, rate of perceived exertion is an accurate measure
Maffetone heart rate is a helpful target: take 180-age for target HR
Four things are causal risk factors for atherosclerotic cardiovascular disease: (1) ApoB; (2) insulin resistance; (3) hypertension; (4) smoking
Statin use is inexpensive, accessible, and effective but “If money were no issue, you’d probably just be on PCKS9 inhibitors, ezetimibe, and bempedoic acid.” – Dr. Peter Attia
Tip: don’t skip your eye exams! By looking at the retina and capillaries at the back of the eye, diabetes can be detected earlier
“Exercise is probably the single most important thing we have at our disposal to increase insulin sensitivity.” – Dr. Peter Attia
Sleep, energy balance, hormone balance are key as well
To optimize cardiovascular health and mitochondrial efficiency: start with how much time you’re willing to exercise – then divide that into 80/20 with 80% at zone 2 and 20% at VO2 max
VO2 max sweet spot is 3-8 minutes with 1:1 ratio of rest to recovery – it takes some time to find how much effort you can put out in this time; it’s slower than a Tabata (20 on/10 off x 8 rounds) but by no means endurance
“Exercise is probably the single most important thing we have at our disposal to increase insulin sensitivity.” – Dr. Peter Attia
The difference between normal glucose and type 2 diabetes is just a teaspoon of blood glucose – muscle is the sink for glucose disposal
Smoking and obesity are the greatest modifiable risk factors for cancer
Why obesity? It’s not actually the amount of fate cells; it’s likely the inflammatory environment that comes with obesity –the excess fat that spills into areas where fat accumulation is harmful like around organs, in muscle
Tip: don’t rely on mammograms exclusively, especially if you’re high risk – combine with ultrasound or MRI
“There has been no greater disservice brought by the medical community onto anyone, in particular in this case women, than the abject failure of the Women’s Health Initiative.” – Dr. Peter Attia
Hormone replacement therapy started at the onset of menopause will help most women
Testosterone replacement therapy in men should be based on bloodwork in combination with symptoms – but be conservative, there are side effects for individuals at risk (hair loss, slightly elevated risk of cardiovascular events, acne)

Read the full notes @ podcastnotes.org

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Show notes are available by clicking here

Peter Attia, MD is a highly respected expert in preventive medicine, focused on the crucial subject of longevity and cardiovascular health. He's also the author of the NY Times best selling book Outlive - which I highly recommend if you have not read it already. Peter's philosophy transcends the conventional goal of merely extending lifespan; it's about enriching the quality of every year, ensuring that each stage of life is lived with optimal health and vitality.

In this episode, we discuss:

(00:07:36) Defining cardiovascular disease

(00:09:43) Coronary plaque and fatality risk

(00:11:09) What is cholesterol?

(00:13:34) How ApoB predicts heart disease

(00:21:34) Factors elevating ApoB

(00:25:24) ApoB reference range explained

(00:27:23) Does high ApoB cause cardiovascular disease

(00:37:01) ApoB thresholds for ASCVD prevention

(00:40:27) Dietary factors raising ApoB

(00:39:33) Genetics of ApoB and LDL

(00:53:24) Does low LDL increase cancer?

(00:56:19) Cholesterol-lowering drugs

(00:59:59) Statins, uses, and side effects

(01:03:12) Are statins toxic to mitochondria?

(01:09:56) Ubiquinol for statin-induced muscle soreness

(01:11:09) How to train in zone 2

(01:17:09) Statins and neurodegenerative disease risk

(01:21:54) Cholesterol synthesis in the brain (desmosterol role)

(01:25:58) Statin alternatives – pros and cons

(01:27:30) Ezetimibe

(01:31:01) Bempedoic acid

(01:36:49) Berberine for CVD Risk Reduction?

(01:39:36) Muscle as a glucose sink

(01:45:58) Chronic glucose toxicity and vascular impact

(01:51:38) Hemoglobin A1C Levels and Mortality Data

(01:55:35) 80/20 Zone 2/VO2 Max Training Protocol

(02:02:12) Insights from VO2 max testing data

(02:12:17) How obesity increases cancer risk

(02:15:03) Cancer screening benefits and risks

(02:20:47) Dr. Attia's recommended cancer screening age

(02:28:54) Liquid biopsies for detecting cancer

(02:34:48) CT scans, mammograms and radiation concerns

(02:40:32) Menopause – hormonal shifts and health effects

(02:45:13) Hormone replacement therapy (HRT)

(02:58:57) Perimenopause diagnosis with hormone levels

(03:02:04) HRT's impact on dementia, cancer, and heart disease risk

(03:04:49) Estrogen's role in bone density

(03:07:42) Vitamin D

(03:16:24) Testosterone replacement for women's sexual function

(03:18:47) HRT safety 10 years post-menopause

(03:23:05) Treating low testosterone in men

(03:29:53) TRT side effects and risks

(03:32:33) Ways to reduce blood pressure

(03:39:33) How to measure blood pressure

(03:45:30) Peter's longevity optimization routines

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4 hr
January 06, 2024 Marc Andreessen
Marc Andreessen is a prominent entrepreneur, investor, and software engineer best known for his key role in the development of the early internet. In the early 90s, Marc co-created Mosaic, a pioneering web browser, while a student at the University of Illinois at Urbana–Champaign. In 1994, he founded Netscape, launching the popular Netscape Navigator browser. After selling Netscape to AOL in 1999 for $4.3 billion, Marc founded Opsware, selling it later for $1.6 billion. In 2009, he co-founded Andreessen Horowitz, a venture capital firm that has backed, among others, Airbnb, Facebook, Instagram, and SpaceX. Known for his insights into technology, Marc's early work with Mosaic and Netscape significantly shaped the internet's growth, and his ongoing contributions continue to influence the tech industry.
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3 hr 13 min
January 05, 2024 TIP597: Darwin's Investing Lessons w/ Kyle Grieve
On today’s episode, Kyle shares the lessons he learned from reading What I Learned About Investing From Darwin by Pulak Prasad.
The book is authored by Pulak Prasad, an investor out of India who helps run Nalanda Capital. From 2007 to 2022, they compounded their capital at 19% per annum turning 1 rupee into 13.8 rupees during that time sample!! But more important than their track record is the unique ways they run their fund.
The book illuminates 3 key principles that Nalanda uses for its investing framework:
1. Avoid big risks.
2. Buy high-quality at a fair price.
3. Don’t be lazy – be very lazy.
To help readers understand why he invests this way he dives deep into many of Darwin’s principles to help you understand their potential power in investing.
IN THIS EPISODE, YOU’LL LEARN:
00:00 - Intro
20:26 - What a cheetah can teach you about risk
24:33 - Why you should be more focused on risk than returns
25:40 - How things in nature and investing mostly stay the same
27:42 - Some interesting data on why great companies remain great, and poor companies remain mediocre
28:29 - What a Russian scientist can teach us about the power of focusing on one investing metric to help identify wonderful businesses
34:58 - The importance of robustness in nature, and why you should search for the same attribute in business
37:00 - How to identify businesses that can evolve in a fast-changing world and remain on top
43:01 - What guppies can teach us about honest and dishonest signaling
46:06 - Why we should prioritize the past over making bold predictions
48:11 - How to invest without ever doing a discounted cash flow ever again
51:05 - What bear teeth and finches can teach us about the importance of avoiding noise
55:20 - How to use the presence of noise as an opportunity to outperform
Disclaimer: Slight discrepancies in the timestamps may occur due to podcast platform differences.
BOOKS AND RESOURCES
Join the exclusive TIP Mastermind Community to engage in meaningful stock investing discussions with Stig, Clay, Kyle, and the other community members.
Check out What I Learned About Investing From Darwin.
Learn more about the Berkshire Summit by clicking here or emailing Clay at [email protected].
Follow Kyle on Twitter and LinkedIn.
Check out the books mentioned in the podcast here.
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1 hr 7 min
January 04, 2024 #407 – Guillaume Verdon: Beff Jezos, E/acc Movement, Physics, Computation & AGI
Guillaume Verdon (aka Beff Jezos on Twitter) is a physicist, quantum computing researcher, and founder of e/acc (effective accelerationism) movement. Please support this podcast by checking out our sponsors:
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Transcript: https://lexfridman.com/guillaume-verdon-transcript

EPISODE LINKS:
Guillaume Verdon Twitter: https://twitter.com/GillVerd
Beff Jezos Twitter: https://twitter.com/BasedBeffJezos
Extropic: https://extropic.ai/
E/acc Blog: https://effectiveaccelerationism.substack.com/

PODCAST INFO:
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- Facebook: https://www.facebook.com/lexfridman
- Medium: https://medium.com/@lexfridman

OUTLINE:
Here's the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time.
(00:00) - Introduction
(09:18) - Beff Jezos
(19:16) - Thermodynamics
(25:31) - Doxxing
(35:25) - Anonymous bots
(42:53) - Power
(45:24) - AI dangers
(48:56) - Building AGI
(57:09) - Merging with AI
(1:04:51) - p(doom)
(1:20:18) - Quantum machine learning
(1:33:36) - Quantum computer
(1:42:10) - Aliens
(1:46:59) - Quantum gravity
(1:52:20) - Kardashev scale
(1:54:12) - Effective accelerationism (e/acc)
(2:04:42) - Humor and memes
(2:07:48) - Jeff Bezos
(2:14:20) - Elon Musk
(2:20:50) - Extropic
(2:29:26) - Singularity and AGI
(2:33:24) - AI doomers
(2:34:49) - Effective altruism
(2:41:18) - Day in the life
(2:47:45) - Identity
(2:50:35) - Advice for young people
(2:52:37) - Mortality
(2:56:20) - Meaning of life
3 hr 1 min
December 31, 2023George Mack — The Game of Life (EP.195)
Infinite Loops
Key Takeaways
Viewing life as a video game can help you increase your agency
Don’t look for meaning; look for use
Resourcefulness is the defining characteristic of a high-agency person
“Pessimists sound smart, but optimists make money.” – Jim O’Shaughnessy
The Luck Razor: If you are between two opportunities, choose the one that will give you the potential to experience the greater amount of luck
The alpha is in all the things that the media ignores, but historians will study
If a person can extract all of your opinions based on just one of your opinions, then you might be a non-player character (NPC)
No matter how smart a person is, they cannot create a list of things that will never occur to them
Thinking that you are the genius in the midwit meme is the most midwit behavior possible

Read the full notes @ podcastnotes.org

Writer, marketer, entrepreneur, and master of mental models, George Mack, returns to discuss the top 0.1% of ideas he’s ever come across, from treating life as a video game to spotting high-agency individuals.

Important Links:

George’s Twitter

The Lindy Library

Roy: A Life Well Lived (Rick and Morty)

How to Spot High Agency People

The Mack Meditation

What is ignored by the media — but will be studied by historians?

The Early-Late Razor

Show Notes:

Treating Life as a Video Game

Finding the Important Metrics

Embrace Momentum; Embrace Constraints

How to Spot High Agency People

How to Increase Your Agency

The Mack Meditation & Silence as Alpha

Why Pessimism vs Optimism is the Wrong Debate

The Future of Media

What is Ignored by the Media but will be Studied by Historians?

The Reddit to Facebook Continuum

George’s Most Midwit Opinion

Randomness & Feeding the Algorithm

How to Retain Curiosity

George as Emperor of the World

Books Mentioned:

The Hypomanic Edge: The Link Between (a Little) Craziness and (a Lot Of) Success in America; by John Gartner

Happy: Why More or Less Everything is Absolutely Fine; by Derren Brown

What Works on Wall Street; by Jim O’Shaughnessy

The Secret; by Rhonda Byrne

Gödel, Escher, Bach: an Eternal Golden Braid; by Douglas Hofstadter

The Beginning of Infinity: Explanations that Transform the World; by David Deutsch
1 hr 44 min
December 31, 2023 The Science of Training Your Attention | Dr. Amishi Jha
How to stay focused, fight distraction, and function at your peak.
1 hr 12 min

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