Podcast Notes Playlist: Latest Episodes

Startups are romanticized AFTER they win. But it takes extraordinary grit to have what it TAKES to win. Ben Horowitz, the co-founder of Andreessen-Horowitz, is the perfect guest to tell it like it is, as he has for many years in his books "the Hard Thing About Hard Things" and "What You Do Is Who You Are." Mike Maples, Jr of FLOODGATE interviews Ben to discuss the ups and downs of dealing with "the struggle," and why the best startup leaders are often the ones who simply refused to quit.

Neal Stephenson is a sci-fi writer (Snow Crash, Cryptonomicon, and new book Termination Shock), former Chief Futurist at Magic Leap and first employee of Blue Origin. Please support this podcast by checking out our sponsors: – Mizzen+Main: https://mizzenandmain.com and use code LEX to get $35 off – InsideTracker: https://insidetracker.com/lex and use code Lex25 to get 25% off – Athletic Greens: https://athleticgreens.com/lex and use code LEX to get 1 month of fish oil – Grammarly: https://grammarly.com/lex to get 20% off premium – ExpressVPN: https://expressvpn.com/lexpod and use code LexPod to get 3 months free EPISODE LINKS: Neal’s Twitter: https://twitter.com/nealstephenson Neal’s Website: https://www.nealstephenson.com/

Twenty Minute VC

Podcast Notes Key Takeaways

• “You need just as good business people on your team as you do technology people in order to win” – Brian Singerman
  • Anduril’s team recipe is made for success by having elite technologists and pre-existing relationships with the government
• We need to control our own destiny when it comes to national security – defense products need to be built on-shore, not outsourced
  • Anduril is creating software (Lattice Platform) and hardware for national defense and security
• Every founder needs to have ‘IT’ = Know their unique strengths and effectively supplement their weaknesses with other people
  • In Brian’s opinion, Palmer Luckey has ‘IT’ and compares him to Elon Musk as a technologist visionary
  • Relationships with founders are the key to VC success in this valuation inflation market

Read the full notes @ podcastnotes.org

Brian Singerman is a General Partner @ Founders Fund, one of the most prominent venture firms of the last decade with a portfolio including Anduril, SpaceX, Tesla, Palantir, Stripe, Affirm, Airbnb, Facebook, and many more. As for Brian, he has led investments in the likes of Affirm, Oscar Health, Wish, Asana, Oculus, and Postmates to name a few. Brian also sits on the board or is an observer to The Long Term Stock Exchange, Solugen, Cloud9, Modern Health, and of course, Anduril. Prior to Founders Fund, Brian spent a very successful 4 years as an engineer and executive at Google.

In Today’s Episode with Brian Singerman on Anduril, You Will Learn:

1.) How did Brian first come to meet Palmer and the Anduril team? Where did the meeting take place? How did the discussion go? Did Brian instantly feel that Palmer was special? What about the way Palmer presented, suggested this to Brian?

2.) The Market: What gave Brian the confidence Anduril would be successful where so many others had failed? How did the market change or evolve in a way Brian did expect? In what ways did the market surprise Brian? Does Brian think we will see the relationship between Silicon Valley and the DOD change over time?

3.) Anduril: The Business: Why is Anduril as a business, so hard to copy? How did Brian gain comfort around their defensibility? What does Brian think is the biggest misconception people have of Anduril as a business? How does Brian think about when is the right time to add secondary and ancillary products?

4.) Investing Today: Why is Brian no longer Zoom investing today? What does Brian mean when he says you have to, "play a different game to the hedge funds today"? In what way does he and Founders Fund look to do this? How does Brian think about the current levels of pricing? How does he determine when to pay up vs when to be disciplined?

Drive with Dr. Peter Attia

Podcast Notes Key Takeaways

• Check out The Peter Attia Drive Podcast Episode Page & Show Notes

Read the full notes @ podcastnotes.org

James Clear is the author of the New York Times bestseller Atomic Habits. His extensive research into human behavior has helped him identify key components of habit formation and develop the “Four Laws of Behavioral Change.” In this episode, James provides insights into how both good and bad habits are formed, including the influence of genetics, environment, social circles, and more. He points to changes one can make to cultivate more perseverance and discipline and describes the profound impact habits can have when tying them into one’s self-identity. Finally, James breaks down his “Four Laws of Behavioral Change” and how to use them to create new habits, undo bad habits, and make meaningful changes in one’s life.

We discuss:

• Why James became deeply interested in habits [1:45];
  
• Viewing habits through an evolutionary lens [6:00];
  
• The power of immediate feedback for behavior change, and why we tend to repeat bad habits [9:15];
  
• The role of genetics and innate predispositions in determining one’s work ethic and success in a given discipline [14:30];
  
• How finding one’s passion can cultivate perseverance and discipline [23:15];
  
• Advantages of creating systems and not just setting goals [29:15];
  
• The power of habits combined with self-identity to induce change [36:30];
  
• How a big environmental change or life event can bring on radical behavioral change [50:30];
  
• The influence of one’s social environment on their habits [54:15];
  
• How and why habits are formed [1:00:30];
  
• How to make or break a habit with the “Four Laws of Behavior Change” [1:09:30];
  
• Practical tips for successful behavioral change—the best strategies when starting out [1:16:15];
  
• Self-forgiveness and getting back on track immediately after slipping up [1:30:30];
  
• Law #1: Make it obvious—strategies for identifying and creating cues to make and break habits [1:39:45];
  
• Law #2: Make it attractive—ways to make a new behavior more attractive [1:47:45];
  
• Law #3: Make it easy—the 2-minute rule [1:58:45];
  
• Law #4: Make it satisfying—rewards and reinforcement [2:03:30];
  
• Advice for helping others to make behavioral changes [2:06:00];
  
• More.

Learn more: https://peterattiamd.com/
Show notes page for this episode: https://peterattiamd.com/jamesclear/ 
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Beginner's Mind

✓

Claim

Podcast Notes Check out the Beginner’s Mind episode page.

• Bacterial infections are traditionally treated with antibiotics – but bacteria are becoming increasingly resistant to existing antibiotics
• Antibiotic resistance is described by the World Health Organization (WHO) as one of the biggest threats to global health, food security, and development
• Phage-based pharmaceuticals are making a comeback in the treatment of complex bacterial infections and antibiotic resistance bacteria
• Phages are viruses that evolved with bacteria to hunt, infect, and kill bacteria with high precision
• Tips for fundraising and approaching investors: increase visibility, seek feedback, understand your numbers, think about what you will need in 1-2 years
• Finding the right investor is kind of like dating: “You will meet many people but it doesn’t make sense to start a relationship with every one of them. Ideally, you can choose but you might have to screen a lot of people.”– Alexander Belcredi
• Questions to ask yourself when fundraising: when is the right time to raise money? how much money do I want to raise? Who are the right investors to bring to the table for each time point?

Read the full notes @ podcastnotes.org

These days there is a lot of discussion about the development of diagnostics, therapeutics, and vaccines against the Coronavirus and its disease COVID 19. Viruses are one threat to the health of human beings, and bacteria are another one. Traditionally, bacterial infections are treated with antibiotics, and recently, some bacteria have developed antibiotic resistance.

The WHO describes that Antibiotic resistance is one of the biggest threats to global health, food security, and development today. (https://www.who.int/news-room/fact-sheets/detail/antibiotic-resistance)

Phagomed (https://www.phagomed.com/) is developing a novel approach to treat bacterial infections without antibiotics. How that works, the challenges a company has to face while developing novel drugs, and why not all viruses are evil, you will hear in this episode.

Timestamps:
(00:00) Opening
(02:26) Intro Alexander Belcredi
(03:30) Foundation of Phagomed
(06:45) Phages – An Alternative to Antibiotics
(08:10) The Different Types of Viruses
(09:20) Why Are There Not Sufficient Solutions against Bacterial Infections?
(10:50) Competitive Landscape in the Anti-bacterial Industry
(12:30) Status of Clinical Development of Phage-Based Therapies in April 2020
(14:35) Are there Registered Phage-Based Therapies on the Market in 2020?
(16:30) How Capital Intensive is the Development of Phage-Based Therapies
(18:15) Funding Sources For Early-Stage Companies in Europe
(20:00) How to Prepare for Fundraising?
(23:30) When is the right time to go on the Market for Fundraising?
(25:00) What are the right expectations for fundraising processes? What is the success rate?
(30:45) What was the biggest challenge for Phagomed in Fundraising Phases?
(32:30) Is there a suitable time for Fundraising?
(35:20) How Long Does it Take from Starting a Financing Round to The Closing?
(36:55) Raising a Series A in 2020 – Resulted in an Acquisition in 2021
(37:55) Milestone Planning for a Series A Round
(39:05) European Public Funds to Leverage Private Investments
(42:25) What Advice Would you Give Your Younger Self Who Is at the Beginning of His Journey?

Shownotes @ PodcastNotes:
Link

More information:  
https://www.phagomed.com/
https://www.lifescienceget2gether.com/
https://linktr.ee/soschner

Video to the episode:
https://youtu.be/YHTR8yMoC3w

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Huberman Lab

Podcast Notes Key Takeaways

• Heavy lifting increases testosterone release which has important benefits for muscle growth, ligament and tendon health, and bone density
• Training protocol to increase testosterone: 6 x 10 protocols (6 sets of 10 reps) at 80% of 1RM with 2-minute rest between sets – work at acload you can sustain intensity over all 10 reps
• If the goal is muscle growth, stick to high-intensity loads 2x per week and lower intensity (but higher volume) the remainder of your workouts
• If you’re trying a new diet or exercise program, stay consistent for 12 weeks to train adaptation and stay in tuned with where the body is along the way
• Use the trainability of the body to your advantage! Don’t be stuck on a fixed routine for exercise, nutrition, or recovery – be deliberate in your protocols
• For the most benefit, periodize cold exposure: use it less when trying to maximize muscle growth or power; use more post-race or major events before the next training block
• Teach the body to preferentially use a specific fuel source through diet & exercise manipulation – fat at low intensity, carbohydrate at high intensity
• You’re better off having a shorter duration of training with higher quality than prolonging a mediocre session

Read the full notes @ podcastnotes.org

In this episode, I talk to Dr. Duncan French, Ph.D., the Vice President of Performance at the UFC Performance Institute and a world-class performance specialist. We discuss specific resistance (weight) training regimens for increasing testosterone in men and women and how to vary mechanical loads and rest between sets and workouts to optimize hormone output and training results. We also discuss how stress-induced "catecholamines" can increase testosterone or decrease it, depending on duration and mindset. And we discuss specific cold- and heat- therapies for increasing resilience, reducing inflammation, heat shock proteins and more. We discuss nutrition for training and how to match nutrition to training goals and metabolic flexibility. We discuss mental focus and how long to train for skill development. Finally, we discuss how mixed martial arts and the UFC Performance Institute are a template for exploring human performance more generally. This episode is intended for anyone interested in athletic and mental performance: athletes, students, and recreational exercisers and includes both science and many practical tools people can apply in their own training. 

 

Thank you to our sponsors:

• ROKA - https://roka.com/ -- code "huberman"
• Helix - https://helixsleep.com/huberman 
• Headspace - https://headspace.com/specialoffer  

 

Dr. Duncan French:

• Instagram - https://www.instagram.com/dr_duncan_french
• LinkedIn - https://www.linkedin.com/in/duncan-french-phd-a41bb9122

 

Our Patreon page:

• https://www.patreon.com/andrewhuberman 

 

Supplements from Thorne:

• http://www.thorne.com/u/huberman 

 

Social:

• Instagram - https://www.instagram.com/hubermanlab 
• Twitter - https://twitter.com/hubermanlab 
• Facebook - https://www.facebook.com/hubermanlab 
• Website - https://hubermanlab.com 
• Newsletter - https://hubermanlab.com/neural-network 

 

Timestamps:

• 00:00:00 Dr. Duncan French 
• 00:02:27 Roka, Helix Sleep, Headspace
• 00:05:44 Duncan’s Background in Exercise Science
• 00:11:45 How Certain Exercises Increase Testosterone
• 00:16:22 What Kind of Training Increases Testosterone & Growth Hormone?
• 00:20:19 Intensity: Mechanical Load; Volume: Metabolic Load; Inter-set Rest Periods
• 00:25:25 Training Frequency & Combining Workout Goals  
• 00:29:35 How Stress Can Increase or Decrease Testosterone 
• 00:36:55 Using Cold Exposure for Mindset, Anti-Inflammation, Muscle-Growth
• 00:46:55 Skill Development
• 00:50:05 Why Hard Exercise Creates Brain Fog: Role of Nutrition 
• 00:53:55 Low-Carbohydrate Versus All-Macronutrient Diets on Performance
• 00:56:15 Ketones & Brain Energy, Offsetting Brain Injury; Spiking Glucose During Ketosis
• 00:59:13 Metabolic Efficiency, Matching Nutrition to Training, “Needs Based Eating”
• 01:05:00 Duncan’s Work with Olympic Athletes, NCAA, UFC (Ultimate Fighting Championship)
• 01:08:00 Why UFC & MMA (Mixed-Martial Arts) Are So Valuable for Advancing Performance
• 01:12:40 Voluntarily Switching Between Different States of Arousal
• 01:14:30 Heat, Getting Better at Sweating, Heat Shock Proteins, Sauna
• 01:20:12 Using Rotating 12-Week Training Programs; Logging Objective & Subjective Data
• 01:24:07 Surprising & Unknown Aspects of The UFC and UFC Performance Institute
• 01:27:45 Conclusions, Zero-Cost Support, Sponsors, Supplements, Instagram

 

Please note that The Huberman Lab Podcast is distinct from Dr. Huberman's teaching and research roles at Stanford University School of Medicine. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Huberman Lab Podcast, its employees, guests and affiliates assume no liability for the application of the information discussed.

 

Title Card Photo Credit: Mike Blabac - https://www.blabacphoto.com 

In this episode Shaan (@ShaanVP) is joined by Steph Smith (@stephsmithio) for an idea packed episode. They start off talking about opportunities around spending your FSA dollars and on swag packs. They transition to talk about the role of automation at companies and Steph shares how she would go about automating repetitive parts of her role. The end the episode talking about Steph's new course, approaches to building a company, and Fidelity allowing trading accounts for teenagers.

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* Want Steph's course? You can find it at https://doingtimeright.com

* Want to be featured in a future episode? Drop your question/comment/criticism/love here: https://www.mfmpod.com/p/hotline/

* Support the pod by spreading the word, become a referrer here: https://refer.fm/million

* Have you joined our private Facebook group yet? Go to https://www.facebook.com/groups/ourfirstmillion and join thousands of other entrepreneurs and founders scheming up ideas.

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Show notes:

* (1:06) Intro

* (2:20) Ideas around spending your FSA dollars

* (15:58) Ideas around giving out awesome swag

* (21:52) The role of chief automation officer

* (27:37) Building a company around automation

* (35:03) Giving away free alcohol as marketing

* (41:22) How Steph invests her time & money

* (43:50) Steph's new course - doingtimeright.com

* (47:44) Approaches to building a company

* (51:39) Fidelity allowing teenagers on the platform

* (56:52) How to find Steph online

Huberman Lab

Podcast Notes Key Takeaways

• The immune system has three main systems of protection: physical barriers (e.g., skin, eyes), innate immune system (e.g., white blood cells, killer cells), adaptive immune system (e.g., creation of antibodies)
• Sickness-related behaviors look a lot like depressive symptoms leading to a theory that depression involves activation of inflammatory cytokines
• Stimulation of the dopamine pathway can accelerate healing and liberate systems in the body which allow inflammatory pathways to go down and anti-inflammatory pathways to go up
• Wim Hof breathing is a zero-cost tool shown to enhance the immune system by releasing adrenaline and reducing the effects of illness symptoms
• Wim Hof breathing steps:(1) 20-30 deep inhales and exhales through nose; (2) exhale of all air to empty lungs; (3) hold breath for up to 60 seconds; (4) repeat 2-4 rounds
• Maintaining a healthy microbiome (gut, eyes, mucus) supports good health: nasal breathe as often as possible, don’t touch eyes after touching other things, ingest fermented foods to enhance gut microbiota

Read the full notes @ podcastnotes.org

This episode teaches you a lot about the immune system, immune-brain interactions and offers 12 potential tools for enhancing immune system function. I discuss how our immune system works and science-supported tools we can use to enhance our immune system.

I discuss the innate and adaptive immune systems and our various microbiomes-- not just in our gut but also in our nose, eyes and mouth and how to keep them healthy. And I review how specific patterns of breathing and foods maintain a healthy mucosal barrier that is crucial for fighting infections. I discuss how certain neurochemicals called catecholamines enhance our immune system function and how to use specific breathing protocols, types and timing of heat and cold exposure, and, if appropriate, supplementation to activate catecholamines. I also discuss the role and use of serotonin for the sake of accessing the specific types of sleep for recovering from illness, and I discuss how to increase glymphatic "washout" of brain debris during sleep. I also review fever, the vagus nerve and the use of atypical yet highly effective compounds for rhinitis (nasal inflammation).

Thank you to our sponsors:

• ROKA - https://www.roka.com -- code: "huberman"
• Athletic Greens - https://www.athleticgreens.com/huberman
• InsideTracker - https://www.insidetracker.com/huberman

 

Our Patreon page:

• https://www.patreon.com/andrewhuberman 

 

Supplements from Thorne:

• http://www.thorne.com/u/huberman 

 

Social:

• Instagram - https://www.instagram.com/hubermanlab 
• Twitter - https://twitter.com/hubermanlab 
• Facebook - https://www.facebook.com/hubermanlab
• Website - https://hubermanlab.com
• Newsletter - https://hubermanlab.com/neural-network

 

Links:

• How and Why The Immune System Makes Us Sleep - https://www.nature.com/articles/nrn2576 

 

Timestamps:

• 00:00:00 The Mind & Immune System, New Findings: Acupuncture & Fascia
• 00:03:00 Sponsors: ROKA, Athletic Greens, InsideTracker
• 00:07:41 Foundational Tools & Practices for a Healthy Immune System
• 00:11:20 Immune System Basics: Skin/Mucous, Innate & Adaptive Immune System
• 00:17:08 Killer Cells, Complement Proteins (“Eat Me!” Signals), Cytokines (“Help Me!” Signals)
• 00:21:06 The Adaptive Immune System: Antibodies
• 00:28:00 Tool 1: Nasal Microbiome and “Scrubbing” Bacteria & Viruses; Nasal Breathing
• 00:30:33 Tools 2 & 3: (Not) Touching Your Eyes; Gut Microbiome & Fermented Foods
• 00:34:20 Some Interleukins Are Anti-Inflammatory
• 00:34:56 Sickness Behavior
• 00:39:08 Some People Seek Care When Sick, Others Want to be Alone
• 00:42:00 Sickness Behavior & Depression: Cytokines
• 00:43:40 Reduced Appetites When Sick: Protein, Iron, Libido
• 00:46:45 Vagus-Nerve Stimulation: Fever, Photophobia, Sleepiness
• 00:53:03 Humoral (Blood-Borne) Factors, & Choroid Change Your Brain State
• 00:55:04 Tools 4, 5: Reducing Sickness: Glymphatic Clearance, Pre-Sleep Serotonin, 5HTP
• 01:07:03 Tool 6: Hot Showers, Saunas, Baths & Cortisol, Heath-Cold Contrast
• 01:10:53 Feed a Fever & Starve a Cold (?), Adrenaline
• 01:12:36 Tool 7: Activating Your Immune System w/Cyclic-Hyperventilation, Alkalinity
• 01:29:10 Brain Chemicals & Cyclic-Hyperventilation; Catecholamines, Dopamine
• 01:32:10 Mindsets & Immune Function; Yes, You Can Worry Yourself Sick
• 01:37:00 Tool 8: Healthy Mindsets, Hope, Dopamine; Tool 9: Tyrosine; Tool 10: Cold Exposure
• 01:42:05 Once You’re Already Sick: Accelerating Recovery; Tool 11: Spirulina, Rhinitis
• 01:46:09 Histamines, Mast Cells
• 01:49:22 Tool 12: Acupuncture: Mechanism for How It Reduces Inflammation; Fascia, Rolfing 
• 01:53:40 Mechanistic Science & Ancient Practices
• 01:58:00 Synthesis, Ways to Support Us (Zero-Cost), Sponsors, Supplements, Social Media

 

Please note that The Huberman Lab Podcast is distinct from Dr. Huberman's teaching and research roles at Stanford University School of Medicine. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Huberman Lab Podcast, its employees, guests and affiliates assume no liability for the application of the information discussed.

 

Title Card Photo Credit: Mike Blabac - https://www.blabacphoto.com

In this episode Sam (@theSamParr) and Shaan (@ShaanVP) update "Sara's List". This was a list of companies Sam and his wife created 5 years ago when she was looking for a job. What was the criteria? They had to be established startups who had the potential to 5-10x over the next 5 years. She went with Airbnb. If you are looking for a new job, check out these 12.

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* Want to be featured in a future episode? Drop your question/comment/criticism/love here: https://www.mfmpod.com/p/hotline/

* Support the pod by spreading the word, become a referrer here: https://refer.fm/million

* Have you joined our private Facebook group yet? Go to https://www.facebook.com/groups/ourfirstmillion and join thousands of other entrepreneurs and founders scheming up ideas.

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Show notes:

* (1:01) Sara's List 2.0

* (6:59) Flexport

* (9:30) Zapier

* (13:16) Uniswap

* (18:07) Anduril

* (21:45) Replit

* (27:39) Airtable

* (31:01) Figma

* (33:38) Rippling

* (36:35) OpenStore

* (40:23) Faire

* (41:33) NexHealth

* (43:31) OneTrust

What’s it like to run a startup that has achieved its goal of impacting humanity at a time of desperate need? Moderna CEO Stephane Bancel joins Mike Maples, Jr of FLOODGATE to discuss the power of taking offensive risks to seize unlikely futures with massive upside, sometimes with the result of changing the odds of life itself. For founders seeking greatness, the conversation also teases out many of the enduring lessons of how we can increase the odds of creating massive breakthroughs.