Dr. Carl Hart is a serious man with a fascinating life. His book, High Price, tells the story of his journey from the bad part of Miami to the upper reaches of Ivy League academia. In this conversation, we talk about why drugs are so hard for our society to get real about, and how often they've been political tools used against marginalized populations and how antithetical to good research and decent society these political uses are.

Fifteen years ago, Dave Asprey took a look at himself and didn't like what he saw: he was about 100 pounds overweight, had chronic nosebleeds, slept poorly, and felt like crap. But unlike most of us, he had the time and financial resources to focus his considerable intelligence on his predicament. What he discovered about his own condition turned out to be applicable to the rest of us: chronic infections, fungal contamination, vitamin deficiencies, dietary craziness—you name it. Bio-hack your way to health.

We talk sparkling water, nitrous oxide, political consulting, Mormonism, strip clubs, the war on drugs, revolution, and murses (man-bags, European carry-alls).

Kim Airs is a sex toy entrepreneur (I had to look up the spelling), motorcycle maven, and militantly free spirit. She rode her motorcycle into the depths of Topanga Canyon to chat with me about working for Larry Summers at Harvard, cornering the market on dildos, and "flatbacking for fun and profit."

Natasha is a very smart high-energy actress/comedian who's blazing a meteoric path across the Hollywood sky. We talk about everything from women's rights to dogs giving birth to Fleshlights in the shower.

Man, this one ranges far and wide. We talk comedy (these dudes are hilarious), good ways to use bad words, porn in the Vatican, and what it's like to be raised by deaf parents.

Conner Habib is a gay porn star, a scholar of human sexuality, and an evolutionary biologist with thoughtful insights on all those subjects and far more. Join us in a cloud overlooking the Pacific Ocean for this wide-ranging conversation.

Comedian, Ari Shaffir and I talk about everything from Elvis, to fat Jesus, to our private fears to advice on peeing in public in this podcast that flows deep and wide as the mighty Mississippi.

Duncan is the madman who first got me into podcasting, as well as various other kinds of trouble, so it's fitting that he and our mutual pal, Daniele help me celebrate this 30th episode of Tangentially Speaking. There must be some numerical convergence there: 3 & 30. Our friend Kyle Del Bonis joined us on the spur of the moment and although we only had 3 mics, he chipped in some of his characteristically deep shit.

Baron Vaughn is a comedian and actor based in Los Angeles. He and Chris talk about comedy, acting, and growing up on the rough side of Vegas.