Physician-scientist David Fajgenbaum was dying from a rare disease that didn't have a cure — until he discovered a lifesaving drug that wasn't originally intended for his condition. In an astonishing talk, he shares how his near-death experience led him to cofound the nonprofit Every Cure, which is using AI to uncover hidden treatments in existing medicines in order to save lives. (This ambitious idea is part of The Audacious Project, TED’s initiative to inspire and fund global change.)

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In this powerful and personal talk, Quentin Mezetin shares his journey raising two sons with autism—and the challenges of parenting in a world that often treats neurological differences as deficits. As he reflects on his family’s experience, he points to a powerful statistic from The Centers for Disease Control and Prevention in 2000—1 in 150 children in the U.S. were diagnosed with autism; by 2020, that number rose to 1 in 36. This rise isn't just a data point—it’s a call to action. Quentin urges us to build a society that uplifts and includes every child, and the need to confront ableism head on.

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Imagine if one day, your quiet neighborhood came alive with a steady hum… and it never went away? All throughout the United States, data centers are popping up next door and in your backyards. These buildings guzzle millions of water, cause noise pollution, and are raising homeowners’ utility bills. In this first episode of a four-part miniseries, Sherrell interviews environmental health scientist Dr. Jacoby Wilson on what happens when data centers infiltrate a neighborhood. They discuss why data centers disproportionately undermine working class communities and how Dr. Wilson is working developing ordinances to better regulate data centers and holding planning commissions accountable.

This episode is part of a special series on TED Tech on data centers and their impact on our environment and communities. Listen to the rest of the series, only on TED Tech: https://link.mgln.ai/BvgoLQ

Talk featured

How to build an equitable and just climate future | Peggy Shepard

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Joel Bervell was one of the only Black students in his medical school program. After noticing how misconceptions about race were embedded in health care, he turned to social media to raise awareness about the harmful impact of biases in medicine. He unpacks the long history of race-based health care disparities — and shows what the medical field can do to better serve all patients. After the talk, Joel and Shoshana talk about the role AI and tech play in perpetuating biases and Joel's forthcoming animated children tv show, The Doctor Is In.

(This episode originally aired in 2025)

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In a society that grows ever more risk averse, how do we balance fun and competition with our responsibilities to keep one another safe? In this talk, sport science professor Ben Jones explores our assumptions about contact sports. He reflects on our perceptions of risk and reward and offers a path to a safer sporting experience for amateurs and professionals alike.

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Dr. Alicia Zhou is the Chief Executive Officer of the Cancer Research Institute—the oldest nonprofit in the world devoted exclusively to cancer immunology and immunotherapy. She joins Shoshana to discuss the innovations happening in cancer research, how immunotherapy is different from chemotherapy and radiation, what doctors can do to make clinical trials less intimidating, and why the conversation around cancer will change in the next 10 years.

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Picture this. You're scrolling late at night and a reel pops up advertising a seemingly magical wellness product with some scientific-sounding marketing language. Do you stick around and maybe even believe it? Or do you scroll away? In this episode, Shoshana explores the mind, and how perception affects it. She shares two talks about how different people can experience reality in wildly different ways. First, Alex Rosenthal shares how having aphantasia prevents him from generating mental images, then Susan G. Wardle dives into the science of perception and why some people see faces in places that don’t exist, like clouds and even potato chips.

Talk featured

Can you picture things in your mind? I can't | Alex Rosenthal

What it means if you can see faces in objects | Susan G. Wardle

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Why do we feel exhausted all the time? We’ll get through the workday, collapse on the couch, scroll for a while, and go to bed… but wake up still feeling depleted. In this episode, Shoshana seeks to understand the concept of“deep rest.” She speaks to psychologist Dr. Alexandra Crosswell on the role stress plays in our daily lives and what safety has to do with bodily repair and restoration.

Talk featured

What’s the best position to sleep in? | Rachel Marie E. Salas

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In a world growing louder, faster and more fractured, author Pico Iyer makes the case for a radical act of repair. Explore why tapping into silence may be the best medicine you can give yourself, and everyone around you.

(Following his talk at TED2025, he joins Elise Hu, host of TED Talks Daily, to share how he finds time for silence and mindfulness in a hyperactive world, why he avoids going online and how his previous TED Talk about ping pong led to him being cast in the film “Marty Supreme.”)

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Does eating local honey help reduce your allergies through microexposure to local pollen? How effective is at-home allergies test? And why do so many Olympic athletes have asthma? These are some of the questions raised in today’s conversation with immunologist Dr. Zachary Rubin. From cat dander to pollen to peanuts, Dr. Rubin discusses how having minor to severe allergies can affect your health and what you can do to manage your allergies.

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