Loneliness is an epidemic in America, even for people who are married. It is a major driver of depression and it can drive people to desperate measures to feel less lonely, including having an affair.

This week's guest "Sabrina" didn't initiate her affair because she wasn't feeling fulfilled sexually -- she was feeling neglected by her husband and lonely and friendless. The man she is having an affair with has since become her best friend and she can't imagine her life without him. Now she worries about what will happen to her if he ever chooses to end their affair, or if her husband, who supports her financially, finds out about her infidelity. Jo is also joined by psychiatrist Dr. Gail Saltz and therapist Dr. Lori Gottlieb who both share their thoughts on loneliness and infidelity.

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