The a16z Show

A new paper, “Some Simple Economics of AGI,” is making the rounds—Web3 with a16z we sat down with author Christian Catalini (MIT Crypto Economics Lab) and Eddy Lazzarin (CTO of a16z crypto), in conversation with Robert Hackett, to unpack what AGI could mean for work and markets.

EPISODE NOTES: 

A hot paper — "Some Simple Economics of AGI" — has been making the rounds, so we sat down with the author, covering: 

Featuring Christian Catalini (founder of MIT Crypto Economics Lab) and Eddy Lazzarin (CTO of a16z crypto) in conversation with Robert Hackett, our discussion dives deep into how automation is reshaping labor markets, as well as the nature of intelligence. 

What do these changes mean for startups, the future of work, and your career?

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Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

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Erik Torenberg sits down with Jacob Helberg to discuss AI, manufacturing, supply chains, and the new geopolitics of technology. Drawing on themes from Helberg’s book The Wires of War, they explore why hardware, industrial capacity, and secure supply chains have become central to both economic strength and national security.

They also unpack what it means to “win the AI race” — from model leadership and global adoption to energy, compute, tariffs, and reindustrialization in the U.S.

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Find Jacob Helberg on X: https://x.com/jacobhelberg

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Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

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Vishal Misra returns to explain his latest research on how LLMs actually work under the hood. He walks through experiments showing that transformers update their predictions in a precise, mathematically predictable way as they process new information, explains why this still doesn't mean they're conscious, and describes what's actually required for AGI: the ability to keep learning after training and the move from pattern matching to understanding cause and effect.

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Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

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In this episode, originally aired on Big Technology Podcast, Olivia Moore discusses whether AI startups can compete with the big chatbots, why American sentiment toward AI is so negative, and what she learned from giving LLMs personality tests. She also breaks down where ChatGPT, Claude, and Gemini are diverging, why Open Claw signals a new wave of agentic products, and what makes memory the most underrated feature in consumer AI.

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Follow Olivia Moore on X:  https://x.com/omooretweets

Follow Alex Kantrowitz on X:  https://x.com/Kantrowitz

List to Big Technology Podcast: https://www.youtube.com/playlist?list=PLADd6sStSis77HKfbf4KCY6SvthfxeUgn

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Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

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Marc Andreessen joins David Senra for a conversation about entrepreneurship, history, and what drives some of the world’s most ambitious builders.

In this conversation with David, Marc reflects on patterns he’s seen across great founders, why many of them focus relentlessly on building rather than introspection, and how technology and entrepreneurship continue to shape the future.

Resources:

David Senra

Website: https://www.davidsenra.com

X: https://x.com/davidsenra

Show notes: https://www.davidsenra.com/episode/ma...

Marc Andreessen

X: https://x.com/pmarca

a16z: https://a16z.com/author/marc-andreessen

Substack: https://pmarca.substack.com

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Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

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This conversation with Emil Michael, undersecretary of defense for research and engineering and acting director of the Defense Innovation Unit, was recorded at the a16z American Dynamism Summit in Washington, D.C. Michael walks through how he inherited a department running 14 undefined technology priorities, cut them to six, and made applied AI number one. He also gives the first detailed account of why commercial AI contracts written under the previous administration created a vendor-lock crisis that put active military operations at risk.

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Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

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This conversation with Alex Karp, cofounder and CEO of Palantir, was recorded at the a16z American Dynamism Summit in Washington, D.C. Karp discusses the role of technology in modern warfare, Silicon Valley's obligations to national defense, and why he believes America's single greatest competitive advantage is its ability to cultivate and protect unconventional talent.

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Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

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In this episode, previously aired on Cheeky Pint, Garrett Langley describes how a stolen gun in his Atlanta neighborhood led him to build Flock Safety, now deployed in more than 6,000 cities and involved in clearing over a million crimes last year. He covers how the product has evolved from license plate cameras to drones, real-time 911 integration, and an AI-powered orchestration layer for city safety.

Resources:

Follow Garrett Langley on X: https://twitter.com/glangley

Follow John Collison on X:   https://twitter.com/collision

Listen to Cheeky Pint: https://www.youtube.com/playlist?list=PLcoWp8pBTM3BxiPMHCj0YJ4wvGbUOYZIG

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Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

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Anish Acharya speaks with Olivia Moore about the latest edition of the a16z Top 100 AI Apps report. They cover why ChatGPT is still 30 times bigger than Claude on web, how the three major platforms are specializing for different users, what global adoption data reveals about cultural attitudes toward AI, and why agents, memory, and voice are about to change everything.

Resources:

Follow Anish Acharya on X: https://twitter.com/illscience

Follow Olivia Moore on X: https://twitter.com/omooretweets

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Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

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Daisy Wolf speaks with Dr. Andrew Huberman, professor of neurobiology and ophthalmology at Stanford University and host of the Huberman Lab podcast. They discuss how the pandemic sparked a consumer health revolution, the emerging peptide and GLP landscape, what the science actually says about focus drugs, and the neurotechnologies Huberman believes will let us write to our own biology within the next five years.

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Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

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