The a16z Show

Ben, Marc, and Erik Torenberg are joined by Brian Schimpf, Co-Founder & CEO of Anduril, and Chris Power, Founder & CEO of Hadrian. Together, they dig into America’s defense production gap: why the U.S. can out-innovate but not out-produce—and what it will take to turn that around.

They discuss why U.S. war games show we run out of munitions in a week, the myth of “exquisite-only” systems, how to rebuild industrial capacity with software-led automation, financing factories like data centers, and what it takes to create real deterrence in a Taiwan scenario.

Timecodes: 

0:00 Introduction

0:27 Technical Superiority vs. Industrial Scale  

3:59 The Decline of US Manufacturing  

7:23 Challenges in Onshoring & Skilled Labor  

13:27 Supply Chains & Rare Earths  

15:34 Automation, Software, and Catching Up  

17:15 Complexity of Modern Production  

23:34 Strategic Policy & Industrial Planning  

26:37 Regulatory Barriers & State vs. Federal Roles  

35:27 Talent, Data Centers, and Financial Engineering  

38:33 China’s Industrial Policy & US Response  

46:07 US Manufacturing, National Security, and the China Challenge  

52:00 Demographics, Long-Term Outlook, and Closing Thoughts  

Resources: 

Find Chris on X: https://x.com/chris_power

Find Brian on LinkedIn: https://www.linkedin.com/in/bschimpf/

Marc on X: https://x.com/pmarca

Marc’s Substack: https://pmarca.substack.com/

Ben on X: https://x.com/bhorowitz

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The views expressed here are those of the individual personnel quoted and are not the views of a16z or its affiliates. This content is provided for informational purposes only, and should not be relied upon as legal, business, investment, or tax advice. Furthermore, this content is not directed at nor intended for use by any investors or prospective investors and may not under any circumstances be relied upon when making a decision to invest in any a16z funds. PLEASE SEE MORE HERE: https://a16z.com/disclosures/

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Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

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Today we’re sharing a feed drop from Cheeky Pint, where Stripe cofounder and president John Collison chats with legends in technology over a pint of Guinness.

In this episode, John is joined by a16z cofounder Marc Andreessen and tech investor Charlie Songhurst for a candid conversation about bubbles, downturns, and the psychology of markets. They discuss what makes Silicon Valley so hard to replace, the deep history of the Valley’s ecosystem, and the future of media. From the lessons of the dot-com crash to the future of venture capital and startups, this is an inside look at how big cycles shape innovation and what it takes to build on the frontier.

Timecodes: 

0:00 Introduction 

1:56 Marc Andreessen’s early internet stories

3:10 Silicon Valley, risk, and downturns

8:30 Marc Andreessen’s early internet days

11:52 Investing across cycles

16:30 Can you tell when you’re in a bubble?

19:10 Trust, high-status VCs & preferential attachment

27:00 Venture capital, startups, and investment cycles

33:34  East Coast vs. West Coast: risk and culture

44:00 High trust culture in Silicon Valley

50:00 Why Silicon Valley, not Boston or Europe?

55:00  Company tragedies and missed opportunities

1:00:00 The internet boom, bubbles, and AI parallels

1:15:00 AI’s impact: productivity, jobs, and society

1:35:00 Crypto, stablecoins, and fintech

1:50:00 Public vs. private markets & venture strategy

2:00:00 Big companies, competition, and bureaucracy

2:05:00 Boards, governance, and the Elon Musk method

Resources: 

Watch more episodes from Cheeky Pint: https://www.youtube.com/@stripe

Listen to Cheeky Pint on Apple Podcasts: https://podcasts.apple.com/us/podcast/cheeky-pint/id1821055332

Find John on X: https://x.com/collision

Find Charlie on LinkedIn: https://www.linkedin.com/in/charlessonghurst/

Follow Marc on X: https://x.com/pmarca

Marc’s Substack: https://pmarca.substack.com/ 

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This information is for general educational purposes only and is not a recommendation to buy, hold, or sell any investment or financial product. Any investments or portfolio companies mentioned, referred to, or described in this podcast are not representative of all a16z investments and there can be no assurance that the investments will be profitable or that other investments made in the future will have similar characteristics or results. A list of investments made by a16z is available at https://a16z.com/investment-list/. All investments involve risk, including the possible loss of capital.  Past performance is no guarantee of future results and the opinions presented cannot be viewed as an indicator of future performance. Before making decisions with legal, tax, or accounting effects, you should consult appropriate professionals. Information is from sources deemed reliable on the date of publication, but a16z does not guarantee its accuracy.

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Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

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Scaling laws took us from GPT-1 to GPT-5 Pro. But in order to crack physics, we’ll need a different approach. 

In this episode, a16z General Partner Anjney Midha talks to Liam Fedus, former VP of post-training research and co-creator of ChatGPT at OpenAI, and Ekin Dogus Cubuk, former head of materials science and chemistry research at Google DeepMind, on their new startup Periodic Labs and their plan to automate discovery in the hard sciences.

Follow Liam on X: https://x.com/LiamFedus

Follow Dogus on X: https://x.com/ekindogus

Learn more about Periodic: https://periodic.com/

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Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

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Ads pay for the internet—and they’re about to change again. a16z General Partner Erik Torenberg, entrepreneur and author Antonio García Martínez, and Meta CMO Alex Schultz dive into growth and performance marketing, privacy myths, retail media, and the AI future of “audience-of-one” advertising—plus Instagram what-ifs, WhatsApp as a super-app, and how Meta’s feed shifted from social graphs to AI-ranked content.

Timecodes:

0:00 Introduction 
0:38 Book Inspiration & Positive Perspective on Advertising
4:43 Critiques of Online Advertising & Data Privacy
7:34 The Evolution of Media Business Models
10:12 Content Moderation and Platform Shifts
11:43 Connected vs. Unconnected Content & The Rise of AI
13:34 The Future of AI, Personalization, and Advertising
28:18 Retail Media Networks & First-Party Data
38:18 Alternative Histories: Instagram, Libra, and Industry What-Ifs
46:31 The Impact of AI on Jobs and Company Structure
55:00 The Metaverse, VR, and Future Platforms

Resources:

Make sure to get Alex’s book here!

Follow Alex on X: https://x.com/alexschultz

Follow Alex on Facebook: https://www.facebook.com/alexschultz

Follow Alex on Threads: https://www.threads.com/@alexorig

Follow Antonio on X: https://x.com/antoniogm

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Follow our host: https://x.com/eriktorenberg

Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

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Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

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Announcing our new show, Monitoring the Situation, hosted by a16z General Partners Erik Torenberg and Katherine Boyle, with guest Eddie Lazzarin, CTO of a16z crypto. 

In this first episode, we ask how American Dynamism, consumer, games, and crypto all fit together, from Palmer/Oculus to Marc Andreessen’s Techno-Optimist Manifesto, while also exploring crypto × AD values, parenting in the AI era, and how internet subcultures shape the news.

Timecodes: 

0:00 Introduction

1:25  Tech Coherence: American Dynamism & Consumer Crypto

4:55 The Hero’s Journey in Tech

5:59 Games, Toys, and Defense Innovation

6:38 Crypto & American Values

11:25 Decentralization, Federalism, and Tech

13:08 AI, China, and Competing Values

14:18 Medicine, Parenting, and the Wisdom of Crowds

20:47 ADHD, Diagnosis Incentives, and Education

27:31 Alternative Schooling & AI Tutors

35:46 Parenting, Family, and Modern Support Systems

42:24 Zoomer Culture, Internet Fragmentation, and X

54:38 Media, Social Networks, and Cultural Shifts

Resources: 

Find Eddy on X: https://x.com/eddylazzarin

Find Katherine on X: https://x.com/KTmBoyle

Find Erik on X: https://x.com/eriktorenberg

Stay Updated: 

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Follow our host: https://x.com/eriktorenberg

Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

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Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

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What comes after vibe coding? Maybe vibe researching.

OpenAI’s Chief Scientist, Jakub Pachocki, and Chief Research Officer, Mark Chen, join a16z general partners Anjney Midha and Sarah Wang to go deep on GPT-5—how they fused fast replies with long-horizon reasoning, how they measure progress once benchmarks saturate, and why reinforcement learning keeps surprising skeptics.

They explore agentic systems (and their stability tradeoffs), coding models that change how software gets made, and the bigger bet: an automated researcher that can generate new ideas with real economic impact. Plus: how they prioritize compute, hire “cave-dweller” talent, protect fundamental research inside a product company, and keep pace without chasing every shiny demo.

Timecodes: 

0:00  Introduction & Goals of Automated Researcher

0:43  The Evolution of Reasoning in AI

1:46  Evaluations: From Benchmarks to Real-World Impact

5:15  Surprising Capabilities of GPT-5

6:56  The Research Roadmap: Next 1, 2, 5 Years

7:46  Long-Horizon Agency & Model Memory

9:44  Reasoning in Open-Ended Domains

11:18  The Role and Progress of Reinforcement Learning

13:14  Reward Modeling & Best Practices

14:21  The New Codex: Real-World Coding

16:20  AI vs. Human Coding: The New Default

20:07  What Makes a Great Researcher?

21:14  Persistence, Conviction, and Problem Selection

26:00  Building and Sustaining a Winning Research Culture

31:45  Balancing Product and Fundamental Research

39:00  The Importance of Compute and Physical Constraints

45:50  Maintaining Speed and Learning at Scale

47:18  Trust and Collaboration at OpenAI

Resources: 

Find Jakub on X: https://x.com/merettm

Find Mark on X: https://x.com/markchen90

Find Sarah on X: https://x.com/sarahdingwang

Find Anjney on X: https://x.com/AnjneyMidha

Stay Updated: 

If you enjoyed this episode, be sure to like, subscribe, and share with your friends!

Find a16z on X: https://x.com/a16z

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Follow our host: https://x.com/eriktorenberg

Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

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Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

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Should the US put a price on H-1B visas, or would that block the flow of new talent? Are AI coding agents actually making teams way more productive, or is it just hype? And in the AI platform shift, will the big winners be incumbents or new AI-native startups?

Erik Torenberg is joined by Box co-founder and CEO Aaron Levie, a16z board partner Steven Sinofsky, and a16z general partner Martin Casado to debate the biggest questions in tech. They unpack pricing vs lottery for H-1Bs and what we’re actually optimizing for, why Box now ships a third of its code from AI, the shift from writing to reviewing code, and why bottom-up personal AI tools succeed where top-down “AI pilots” struggle.

Timecodes: 

0:00 Introduction

1:07  Latest immigration policy and who benefits

1:39  Debating the Price on H-1B Visas

2:11  Startups vs. Big Tech: Who Benefits from Policy?

2:31  Market Dynamics and Wage Impacts

3:44  The Lottery System and Startup Challenges

12:25  Labor Markets to Labor Productivity with AIs

14:47  Startups Achieving 10x Productivity with AI

16:43  Early Adopters, Hype, and Measuring Productivity

33:50  AI’s Impact on Professional and Creative Work

37:56  The Rise of AI-Native Startups

40:58  Platform Shifts: Startups vs. Incumbents

42:12  Disruption, Incumbents, and New Opportunities

53:00  The Future of Work and AI Adoption

54:38  Brand Effects and Early Leaders in AI

55:22  Will Incumbents or Newcomers Win the AI Race?

Resources:

Find Aaron on X: https://x.com/levie

Find Steven on X: https://x.com/stevesi

Find Martin on X: https://x.com/martin_casado

Find Erik on X: https://x.com/eriktorenberg

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Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

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Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

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Dr. Jay Bhattacharya is one of the country’s top medical experts and a 24-year professor of medicine at Stanford. After being censored and deplatformed during COVID for his role in opposing harsh lockdowns, he was appointed Director of the National Institutes of Health by President Trump in 2025.

a16z General Partners Erik Torenberg, Vineeta Agarwala, and Jorge Conde join Dr. Bhattacharya to discuss the administration’s role in tackling the autism crisis, how to restore public trust in health authorities, how to make the NIH more dynamic and efficient, and how to streamline publishing and restore academic freedom.

Timecodes: 

0:00 Introduction
1:30 Autism Initiative & New Research
2:45 Drug Discoveries: Leucovorin & Tylenol Caution
4:35 Preterm Birth & Broader Health Initiatives
5:45 The Replication Crisis in Science
8:50 Reforming NIH Funding & Scientific Culture
14:00 Allocation vs. Execution at NIH
17:30 Political & Scientific Decision-Making
22:30 Addressing Life Expectancy & Chronic Disease
27:00 Supporting Early Career Investigators
34:50 Academic Freedom & Open Science
37:30 Rebuilding Public Trust in Public Health
41:00 Communicating Science Amid Uncertainty
47:50 NIH Priorities: Nutrition, Chronic Disease, AI
50:00 The Future of AI in Science & Medicine
53:30 Advice for Rising Scientists
55:00 The Role and Limits of AI in Science

Resources:

Find Dr. Bhattacharya on X: https://x.com/DrJBhattacharya and https://x.com/NIHDirector_Jay

Find Erik on X: https://x.com/eriktorenberg

Find Jorge on X: https://x.com/JorgeCondeBio

Find Vineeta on X: https://x.com/vintweeta

Learn more about the NIH: https://www.nih.gov/

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Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

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Nvidia’s $5 billion investment in Intel is one of the biggest surprises in semiconductors in years. Two longtime rivals are now teaming up, and the ripple effects could reshape AI, cloud, and the global chip race.

To make sense of it all, Erik Torenberg is joined by Dylan Patel, chief analyst at SemiAnalysis, joins Sarah Wang, general partner at a16z, and Guido Appenzeller, a16z partner and former CTO of Intel’s Data Center and AI business unit. Together, they dig into what the deal means for Nvidia, Intel, AMD, ARM, and Huawei; the state of US-China tech bans; Nvidia’s moat and Jensen Huang’s leadership; and the future of GPUs, mega data centers, and AI infrastructure.

Resources: 

Find Dylan on X: https://x.com/dylan522p

Find Sarah on X: https://x.com/sarahdingwang

Find Guido on X: https://x.com/appenz

Learn more about SemiAnalysis: https://semianalysis.com/dylan-patel/

Stay Updated: 

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Follow our host: https://x.com/eriktorenberg

Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

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Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

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In this episode of Honestly with Bari Weiss, we share a special conversation featuring a16z general partner Katherine Boyle in the wake of Charlie Kirk’s shocking assassination.

Katherine reflects on what courage means in a culture where words and debate are increasingly met with violence. Drawing on faith, history, and her own response to recent tragedies, she discusses the idea of martyrdom, not only in its most extreme sense, but also in the small, everyday choices to speak the truth despite risk.

Timecodes: 

0:00  Introduction 

0:49  Remembering Charlie Kirk

2:46  The Meaning of Martyrdom

4:49  Courage and the Choice We Face

9:16  Returning to Normalcy

10:35  The Age of Extremes

12:15 Words, Violence, and the Next Generation

14:10  Reclaiming the Center

18:18  The Power and Danger of Rhetoric

21:55  The Call to Speak Up

Resources: 

Listen to more from Honestly: https://podcasts.apple.com/za/podcast/honestly-with-bari-weiss/id1570872415

Find Bari on X: https://x.com/bariweiss

Find Katherine on X: https://x.com/KTmBoyle

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Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

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Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

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