The Functional Nurse Practitioner

Today we're going to be talking about sleep. 

Just a quick disclaimer that this podcast is meant for educational purposes only and is not meant to diagnose or be a substitute for medical advice from your practitioner.

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**Follow me on Instagram: https://www.instagram.com/thefunctionalnursepractitioner/

** Level up your products: https://www.ewg.org/ewgverified/

**Interesting articles for more information**

The Sleep of the Ring: Comparison of the ŌURASleep TrackerAgainst Polysomnography: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6095823/pdf/nihms-1500634.pdf

GABA and L-theanine mixture decreases sleep latency and improves NREM sleep: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366437/pdf/iphb-57-1557698.pdf

Effect of wearables on sleep in healthy individuals: a randomized crossover trial and validation study: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7849816/pdf/jcsm.8356.pdf

Health Benefits of Lactobacillus gasseri CP2305 Tablets in Young Adults Exposed to Chronic Stress: A Randomized, Double-Blind, Placebo-Controlled Study: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6723420/pdf/nutrients-11-01859.pdf

Plant Extracts for Sleep Disturbances: A Systematic Review: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191368/pdf/ECAM2020-3792390.pdf

Effects of poly-gamma-glutamic acid and vitamin B6 supplements on sleep status: a randomized intervention study: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8155219/pdf/nrp-15-309.pdf

Naturally Occurring Consecutive Sleep Loss and Day-to-Day Trajectories of Affective and Physical Well-Being: https://academic.oup.com/abm/article-abstract/56/4/393/6314765?redirectedFrom=fulltext

Dietary saffron reduced the blood pressure and prevented remodeling of the aorta in L‐NAME‐induced hypertensive rats: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4764118/pdf/IJBMS-11-1143.pdf

Today we are continuing our conversation on altered intestinal permeability – aka leaky gut.  We are diving deep, once again, my friends, deep, into testing and also management for altered intestinal permeability.  Kick back and relax – I think you are going to really enjoy this one.

Just a quick disclaimer that this podcast is meant for educational purposes only and is not meant to diagnose or be a substitute for medical advice from your practitioner.

**Follow me on Instagram: https://www.instagram.com/thefunctionalnursepractitioner/

** Level up your products: https://www.ewg.org/ewgverified/

**Interesting articles for more information**

The Leaky Gut: Mechanisms, Measurement and Clinical Implications in Humans: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6790068/pdf/nihms-1054015.pdf

All disease begins in the (leaky) gut: role of zonulin-mediated gut permeability in the pathogenesis of some chronic inflammatory diseases [version 1; peer review: 3 approved]: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6996528/pdf/f1000research-9-22543.pdf

Leaky Gut As a Danger Signal for Autoimmune Diseases: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5440529/pdf/fimmu-08-00598.pdf

Fructose Promotes Leaky Gut, Endotoxemia and Liver Fibrosis through CYP2E1-Mediated Oxidative and Nitrative Stress: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6783321/pdf/nihms-1023086.pdf

The use of biomarkers associated with leaky gut as a diagnostic tool for early intervention in autism spectrum disorder: a systematic review: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8439029/pdf/13099_2021_Article_448.pdf

The Role of the Gastrointestinal Mucus System in Intestinal Homeostasis: Implications for Neurological Disorders: https://www.frontiersin.org/articles/10.3389/fcimb.2020.00248/full

Is There an Exercise-Intensity Threshold Capable of Avoiding the Leaky Gut?: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7982409/pdf/fnut-08-627289.pdf

Downregulated Gene Expression Spectrum and Immune Responses Changed During the Disease Progression in Patients With COVID-19:  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7188184/

Breaking down the barriers: the gut microbiome, intestinal permeability and stress-related psychiatric disorders: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4604320/pdf/fncel-09-00392.pdf

Intestinal Microbiome, Akkermansia muciniphila, and Medical Nutrition Therapy: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5145007/pdf/14-16.pdf

Today we're going to be talking about a vitally important topic - intestinal permeability.  You may not have heard this term, but you likely have heard the term that's all over social media - leaky gut.  You guys are really gonna love this one.  This is part one in a two part series.  In next week's episode we will get more into testing for leaky gut and different management strategies. 

Just a quick disclaimer that this podcast is meant for educational purposes only and is not meant to diagnose or be a substitute for medical advice from your practitioner.

**Follow me on Instagram: https://www.instagram.com/thefunctionalnursepractitioner/

** Level up your products: https://www.ewg.org/ewgverified/

**Interesting articles for more information**

The Leaky Gut: Mechanisms, Measurement and Clinical Implications in Humans: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6790068/pdf/nihms-1054015.pdf

All disease begins in the (leaky) gut: role of zonulin-mediated gut permeability in the pathogenesis of some chronic inflammatory diseases [version 1; peer review: 3 approved]: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6996528/pdf/f1000research-9-22543.pdf

Leaky Gut As a Danger Signal for Autoimmune Diseases: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5440529/pdf/fimmu-08-00598.pdf

Fructose Promotes Leaky Gut, Endotoxemia and Liver Fibrosis through CYP2E1-Mediated Oxidative and Nitrative Stress: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6783321/pdf/nihms-1023086.pdf

The use of biomarkers associated with leaky gut as a diagnostic tool for early intervention in autism spectrum disorder: a systematic review: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8439029/pdf/13099_2021_Article_448.pdf

The Role of the Gastrointestinal Mucus System in Intestinal Homeostasis: Implications for Neurological Disorders: https://www.frontiersin.org/articles/10.3389/fcimb.2020.00248/full

Is There an Exercise-Intensity Threshold Capable of Avoiding the Leaky Gut?: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7982409/pdf/fnut-08-627289.pdf

Downregulated Gene Expression Spectrum and Immune Responses Changed During the Disease Progression in Patients With COVID-19:  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7188184/

Breaking down the barriers: the gut microbiome, intestinal permeability and stress-related psychiatric disorders: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4604320/pdf/fncel-09-00392.pdf

Intestinal Microbiome, Akkermansia muciniphila, and Medical Nutrition Therapy: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5145007/pdf/14-16.pdf

Today we are going to dive deep into Hashimoto’s autoimmune disease. What exactly is this condition? What are the risk factors for developing this autoimmune condition, are there specific causes for it? What are some signs and symptoms, what are the complications of this condition, and finally, we will talk about the management of Hashimoto’s autoimmune disease. This is going to be a doozy of an episode today. This is a topic I am very passionate about – as I was diagnosed with this autoimmune disease at the beginning of this year. This is a topic we need to discuss, and it needs to be in the forefront of our brains as it is very common!

Just a quick disclaimer that this podcast is meant for educational purposes only and is not meant to diagnose or be a substitute for medical advice from your practitioner.

**Follow me on Instagram: https://www.instagram.com/thefunctionalnursepractitioner/

** Level up your products: https://www.ewg.org/ewgverified/

The Funktional Nutritionist: https://www.thefunktionalnutritionist.com/

Dr. Hyman: https://drhyman.com/

**Interesting articles for more information**

Persisting symptoms in patients with Hashimoto’s disease despite normal thyroid hormone levels: Does thyroid autoimmunity play a role? A systematic review: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8122172/pdf/main.pdf

Hashimoto Thyroiditis: https://www.ncbi.nlm.nih.gov/books/NBK459262/

Hashimoto's Disease: https://www.niddk.nih.gov/health-information/endocrine-diseases/hashimotos-disease

The effects of Nigella sativa on thyroid function, serum Vascular Endothelial Growth Factor (VEGF) – 1, Nesfatin-1 and anthropometric features in patients with Hashimoto’s thyroiditis: a randomized controlled trial: https://www.europeanreview.org/wp/wp-content/uploads/051-059-Myo-inositol-and-selenium-restore-euthyroid-state.pdf

Metformin Reverses Hashimoto’s Thyroiditis by Regulating Key Immune Events: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8193849/pdf/fcell-09-685522.pdf

Microbiota and Thyroid Interaction in Health and Disease: https://www.cell.com/action/showPdf?pii=S1043-2760%2819%2930107-9

The effects of selenium supplementation on antibody titres in patients with Hashimoto’s thyroiditis: https://journals.viamedica.pl/endokrynologia_polska/article/view/EP.a2021.0074/65249

An update on the pathogenesis of Hashimoto’s thyroiditis: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8049926/

The importance of gluten exclusion in the management of Hashimoto’s thyroiditis: https://www.aaem.pl/pdf-136523-71103?filename=The%20importance%20of%20gluten.pdf

Today we are going to talk about sugar. What is sugar – what are the different types of sugars, how do they affect the body, our hormones, and also obviously how do they affect our blood sugar. We’re going to talk about “natural” sugars vs processed sugars. We’re also going to talk about carbohydrates. Why do they matter and how do they contribute to the total body’s sugar burden. We are also going to address why we should even care about sugar. This is going to be a fun and interesting topic, at least in my opinion. I feel like it is a necessary subject so we are better informed and can make informed decisions regarding our intake of sugar, especially as we are in full swing of the holiday season.

Just a quick disclaimer that this podcast is meant for educational purposes only and is not meant to diagnose or be a substitute for medical advice from your practitioner. I am a practitioner, but not your practitioner.

**Follow me on Instagram: https://www.instagram.com/thefunctionalnursepractitioner/

** Level up your products: https://www.ewg.org/ewgverified/

**Interesting articles for more information**

Impact of sugar on the body, brain, and behavior: https://www.imrpress.com/journal/FBL/23/12/10.2741/4704

Pancreatic regulation of glucose homeostasis: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4892884/

Effect of different types of sugar on gut physiology and microbiota in overfed goose: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8187246/pdf/main.pdf

Impact of sugar on the body, brain, and behavior: https://www.imrpress.com/journal/FBL/23/12/10.2741/4704

Hidden in Plain Sight: https://sugarscience.ucsf.edu/hidden-in-plain-sight/

Yogurts vary widely in sugar content, survey shows: https://www.yogurtinnutrition.com/yogurts-vary-widely-in-sugar-content-survey-shows/

Coconut sugar: Is it good for you?: https://www.medicalnewstoday.com/articles/323047#impact-on-blood-glucose-levels

What is maltodextrin and is it safe?: https://www.medicalnewstoday.com/articles/322426#which-foods-contain-maltodextrin

Glycemic Index Research and GI News: https://glycemicindex.com/gi-search/

The lowdown on glycemic index and glycemic load: https://www.health.harvard.edu/diseases-and-conditions/the-lowdown-on-glycemic-index-and-glycemic-load

Human brain sialoglycan ligand for CD33, a microglial inhibitory Siglec implicated in Alzheimer’s disease: https://www.jbc.org/article/S0021-9258(22)00400-8/fulltext

Increased Added Sugar Consumption Is Common in Parkinson's Disease: https://www.frontiersin.org/articles/10.3389/fnut.2021.628845/full

High-Fat, High-Sugar Diet Disrupts the Preovulatory Hormone Surge and Induces Cystic Ovaries in Cycling Female Rats: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5740526/

Today we are going to talk about the benefit of spices.  I thought this would be a great topic as oftentimes we only think about spices to add a flavor – or perhaps we don’t even really think about this either, and maybe only use salt and pepper.  Aside from enhancing your foods, spices also provide a plethora of other benefits that we are going to get into today.

Just a quick disclaimer that this podcast is meant for educational purposes only and is not meant to diagnose or be a substitute for medical advice from your practitioner. I am a practitioner, but not your practitioner.

**Follow me on Instagram: https://www.instagram.com/thefunctionalnursepractitioner/

** Level up your products: https://www.ewg.org/ewgverified/

**Interesting articles for more information**

The effect of Elettaria cardamomum (cardamom) on the metabolic syndrome: Narrative review: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8917848

Dose-Dependent Increase in Unconjugated Cinnamic Acid Concentration in Plasma Following Acute Consumption of Polyphenol Rich Curry in the Polyspice Study: https://www.mdpi.com/2072-6643/10/7/934

Anticancer Properties of Phyllanthus emblica (Indian Gooseberry): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4477227/pdf/OMCL2015-950890.pdf

Antimicrobial Activity of Basil, Oregano, and Thyme Essential Oils: https://www.jmb.or.kr/journal/view.html?doi=10.4014/jmb.1608.08024

Herbs and Spices- Biomarkers of Intake Based on Human Intervention Studies – A Systematic Review: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6532192

The Ruminococci: key symbionts of the gut ecosystem: https://link.springer.com/article/10.1007/s12275-018-8024-4

Ruminococcus gnavus, a member of the human gut microbiome associated with Crohn’s disease, produces an inflammatory polysaccharide: https://www.pnas.org/doi/full/10.1073/pnas.1904099116

The Role of Polyphenols in Human Health and Food Systems: A Mini-Review: https://www.frontiersin.org/articles/10.3389/fnut.2018.00087/full

Effect of Ginger Powder Supplementation in Patients with Non-Alcoholic Fatty Liver Disease: A Randomized Clinical Trial: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6986243/

Culinary Herbs and Spices: Their Bioactive Properties, the Contribution of Polyphenols and the Challenges in Deducing Their True Health Benefits: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4227268/

Prebiotic Potential and Chemical Composition of Seven Culinary Spice Extracts: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5600121/

A single serving of mixed spices alters gut microflora composition: a dose–response randomised trial: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8163817/

Today we are talking about hypothyroidism. Hypothyroidism means that the thyroid is underactive…it is not working appropriately. We are going to talk about the signs and symptoms of hypothyroidism, how to test for hypothyroidism, causes of hypothyroidism, risks associated with hypothyroidism, and finally the management of this condition.

Just a quick disclaimer that this podcast is meant for educational purposes only and is not meant to diagnose or be a substitute for medical advice from your practitioner. I am a practitioner, but not your practitioner.

**Follow me on Instagram: https://www.instagram.com/thefunctionalnursepractitioner/**

Level up your products: https://www.ewg.org/ewgverified/

**Interesting articles for more information**

Hypothyroidism and the Heart: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5512679/

Brain Fog in Hypothyroidism: What Is It, How Is It Measured, and What Can Be Done About It: https://pubmed.ncbi.nlm.nih.gov/35414261/

Selenium supplementation could restore euthyroidism in subclinical hypothyroid patients with autoimmune thyroiditis: https://journals.viamedica.pl/endokrynologia_polska/article/view/45406

Hypothyroidism: Diagnosis and Treatment: https://www.aafp.org/pubs/afp/issues/2021/0515/p605.html

Hypothyroidism: Overview, Causes, and Symptoms: https://www.endocrineweb.com/conditions/thyroid/hypothyroidism-too-little-thyroid-hormone-0

Hypothyroidism: https://my.clevelandclinic.org/health/diseases/12120-hypothyroidism

Cruciferous Vegetables and Thyroid Function: https://cell-logic.com.au/wp-content/uploads/2021/04/Cell-Logic-Cruciferous-Vegetables-Thyroid-Function-v2.pdf

Effect of broccoli sprouts on thyroid function, hematological, biochemical, and immunological parameters in rats with thyroid imbalance: https://pubmed.ncbi.nlm.nih.gov/29080462/

Broccoli sprout beverage is safe for thyroid hormonal and autoimmune status: results of a 12-week randomized trial: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6422739/

Hashimoto's Disease: https://www.niddk.nih.gov/health-information/endocrine-diseases/hashimotos-disease#diet

Autoimmunity and hypothyroidism: https://pubmed.ncbi.nlm.nih.gov/3066320/

Thyroid antibodies explained: https://www.btf-thyroid.org/thyroid-antibodies-explained

Today we are launching The Functional Nurse Practitioner podcast and kicking it off with a bang!  The subject of todays episode is estrogen dominance.  Estrogen dominance greatly impacts women of all ages.  What is estrogen dominance?  How do you test for it?  What are common conditions associated with estrogen dominance?  How does this impact your life if you in fact have estrogen dominance?  What can you do if you have estrogen dominance?  In this episode we discuss all things estrogen dominance.

Just a quick disclaimer that this podcast is meant for educational purposes only and is not meant to diagnose or be a substitute for medical advice from your practitioner. I am a practitioner, but not your practitioner.

**Follow me on Instagram: https://www.instagram.com/thefunctionalnursepractitioner/**

Level up your products: https://www.ewg.org/ewgverified/

**Interesting articles for more information**

*Progesterone and Estrogen Signaling in the Endometrium: What Goes Wrong in Endometriosis?: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6695957/

*Progesterone Actions and Resistance in Gynecological Disorders: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8870180/

*Adipose tissue estrogen production and metabolism in premenopausal women: https://www.sciencedirect.com/science/article/pii/S096007602100042X?via%3Dihub

*Overview of air pollution and endocrine disorders: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5973437/

*Analytical methods for the determination of endocrine disrupting chemicals in cosmetics and personal care products: A review: https://www.sciencedirect.com/science/article/abs/pii/S0039914021005634?via%3Dihub

*B-vitamin intake, one-carbon metabolism, and survival in a population-based study of women with breast cancer: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2673236/

*Impact of different omega-3 fatty acid sources on lipid, hormonal, blood glucose, weight gain and histopathological damages profile in PCOS rat model: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7491187/

*Estrogen metabolism and the diet-cancer connection: rationale for assessing the ratio of urinary hydroxylated estrogen metabolites: https://pubmed.ncbi.nlm.nih.gov/11991791/

*Diagnosis and therapy of fibrocystic breast disease: https://pubmed.ncbi.nlm.nih.gov/2264418/

*Hormone Replacement Therapy Ups Risk of Benign Breast Disease: https://www.breastcancer.org/research-news/20080408

*Breast Cysts: https://my.clevelandclinic.org/health/diseases/15691-breast-cysts