In this fascinating discussion, Dr. Jeff Karp, a top biomedical innovator pulls back the curtain on the difficult journey medical breakthroughs must take to actually help patients. From navigating financial hurdles and clinical trial complexities to manufacturing challenges, hear the surprising barriers promising cures often face on their journey to your local pharmacy. You'll also get an inside look at how real solutions are being developed. Discover how a nasal spray was created to potentially block COVID transmission and learn about groundbreaking "medical superglue" aiming to revolutionize heart repairs. If you've ever wondered what really happens after exciting discoveries are made in white coats and petri dishes, don't miss this amazing conversation revealing the untold story of how cutting-edge science becomes accessible healthcare. Highlights:

00:00 Intro 00:45 Who is Dr. Jeff Karp? 02:30 Complexity of finding and commercializing new solutions 06:42 Dr. Karp's new book overview 08:30 Indigenous holistic approach to health 09:44 Narrowing of the senses we use to experience the world 11:40 Spartan shield for your nose – Profi Nasal Spray 15:10 Developing glue that can work inside the body

Tired of synthetic pleasures leaving you unfulfilled? Former financier and entrepreneur Seth Goldstein knows how easy it is to fall for fake dopamine hits. But he firmly believes that through discipline and authentic challenges like the Spartan Race, people can find genuine happiness and fulfillment. In this episode, Seth shares his journey of creating an authentic snack brand called MASA Chips. From identifying a problem and analyzing reports to frying small batches of chips and testing the product, he offers proven strategies for making a successful business without compromising your idea. He made a 100% healthy and satisfying snack to help people ditch addictive junk and feel the real thing! Highlights: 00:00 Intro 00:52 A demand for discipline & challenge 03:00 Starve yourself of synthetic s**t 05:07 Cucumber salad vs Snickers 06:06 Seth's MASA Chips Company 10:38 Figure out how to fail cheaply 12:18 Find a real problem and solve it

Tired of feeling drained? Struggling with inflammation or other health issues? Mason Kuhr shares his holistic approach to tapping into your inner strength. ​​ ​​Through simple daily rituals like cold exposure, meditation, and burpees, Mason has optimized his energy levels, productivity, and recovery. He'll reveal how reconnecting with nature can boost your immunity, testosterone, and more. ​​ ​​You'll also learn Mason's unique take on making wellness accessible and how Stampede Network is revolutionizing holistic living for the modern man or woman. ​​ ​​Discover real stories of people healing from issues like infertility and immobility through bee products and lifestyle tweaks. Mason will motivate you to optimize your health and performance from the inside out by harnessing your spiritual power. ​​ ​​Highlights: ​​00:00 A spiritual take on health and wellness ​​01:27 The benefits of bee bread ​​03:04 Making holistic wellness cool ​​05:50 Dopamine hacking ​​06:44 Mason's daily routine ​​09:14 Meditation and dealing with stress ​​11:01 What's next for Mason Kuhr?

Dominic Schlueter was a regular kid who loved running. Through consistency, the right influences, and taking action on his dreams, he's built a thriving podcast and brand at just 18 years old. In this episode, Dominic recounts how from a young age he found joy in challenging himself on the track. That drive soon led him to seek out greater obstacles through podcasts and books. And it inspired him to start his own show to share the stories of people that he found inspiring. Dominic talks about his fascination with Joe's podcast and "threats" from his dad to send him to Joe De Sena's infamous farm. Years later, he is having an interview with Joe himself and talking about pushing himself to the limit through running, life-changing lessons he learned about grit, a circle of influence, and turning passion into purpose. Tune in to hear more from this fascinating young man!

Joe De Sena sits down with a young entrepreneur Lukas Pakter, the founder of the SquidHaus fitness apparel company, to discuss sensitive global issues with nuance, as well as Lucas' unconventional path to building his booming athletic apparel brand. Lucas shares his viral strategy of leveraging an "influential army" of top fitness creators to take over the scene. He plans to sell thousands of discounted tickets to Joe's Spartan Race using influencer codes, donating over $1M to charity in the process. Joe gives the plan his stamp of approval. Viewers will learn Lucas's unique brand story, top tips for starting young, and lessons on accountability from these experienced leaders. With open discussion on controversy and actionable advice, this episode is a must-watch for anyone pursuing a business or looking to better understand complex issues. Highlights: 00:00 Joe's "controversial" post on IG 02:34 The conversation has to happen 04:06 We shy away from having a stance 05:59 What does SquidHaus mean and represent? 08:06 Finding a job vs. starting a company 10:04 Leveraging business through Spartan Race 14:34 How to start a business? 16:44 Three things every entrepreneur should do every day 19:55 Three books everybody needs to read 21:57 How to find Lukas Pakter?

Joe De Sena interviews Craig Siegel who is an author and motivational speaker. While having a successful business on Wall St Craig felt unfulfilled. He re-invented himself and constantly pushed himself into discomfort until he found a passion that would get him out of bed in the morning. He now helps others find their true potential and calling.

Joe De Sena sits down with Co-Director of Christspiracy, Kameron Waters who talks about his upcoming film which he and his co-director bought back from Netflix making it the first of its kind to do so. This is the sequel to the popular Seaspiracy, What the Health and Cowspiracy which explores The Spirituality Secret kept hidden for thousands of years. To help Kameron buy the movie back from Netflix they are launching a kickstarter which you can find here: https://www.kickstarter.com/projects/christspiracy/christspiracy-the-spirituality-secret?ref=1l5hn3

Jessie Kanzer, author of UNLOCKING YOUR INNER ZELENSKY shares profound life lessons drawn from Volodymyr Zelensky's words and actions, and shows us how we too can access our Inner Zelensky to improve how we lead, conduct ourselves, and how we live. Jessie Kanzer, a half-Ukrainian child of the USSR who had a small part in Zelensky's first major film, sees Zelensky as "a spiritual leader for our times." Joe sits down with her to discover what we can do to become better leaders.

For those interested in the book please visit: https://us.macmillan.com/books/9781250894762/unlocking-your-inner-zelensky