Learn about Cerebral Folate Deficiency (CFD), its causes, symptoms, and treatments, including folate receptor autoantibodies, dietary strategies, and folinic acid therapy, with insights from Dr. Lindsey Wells.

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In this compelling episode of LymeBytes!, Dr. Myriah Hinchey sits down with Dr. Lindsey Wells to explore Cerebral Folate Deficiency (CFD), an under-recognized cause of neuropsychiatric symptoms often misdiagnosed as purely psychiatric—especially in children.

Dr. Wells explains how folate receptor autoantibodies (FRAT) block or bind folate receptors in the brain, preventing the transport of active folate (5-MTHF) and leading to cognitive, behavioral, and developmental issues. You’ll learn the potential triggers, including dairy exposure, infections, and stress, and why standard blood folate tests often miss this condition.

This episode covers CFD prevalence in conditions like PANS/PANDAS, autism spectrum disorder, and vector-borne diseases, the hallmark symptoms in children and adults, and practical treatment strategies—including dietary interventions and high-dose folinic acid therapy.

Parents and clinicians alike will gain insights into recognizing abrupt behavioral changes, the importance of testing for FRAT, and an integrative approach to treatment that addresses both autoimmunity and neuroinflammation.

Dr. Lindsey Wells is a clinician specializing in neuroimmune and autoimmune disorders in children and adults. In this episode, she shares her expertise on Cerebral Folate Deficiency, folate receptor autoantibodies, and practical treatment approaches that combine dietary management, supplementation, and integrative care.

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Lindsey Wells, ND

Instagram: https://www.instagram.com/lindseywellsnd/?hl=en

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Myriah Hinchey, ND, FMAPS

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Special thanks to ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠TruDose⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ and ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠OxyHealth⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠

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