Most people think of serotonin as a mood hormone. But what if it also plays a role in bone loss?In this episode, Nico Misleh explores emerging research linking elevated serotonin levels to increased osteoporosis risk in post-menopausal women. He breaks down a recent study examining serotonin markers and bone mineral density, and explains why this connection could reshape how we think about hormone balance and long-term bone health.If you are navigating menopause, managing osteoporosis risk, or interested in the deeper hormonal drivers of bone density, this conversation provides important insight into an often overlooked factor in women’s health.Chapters00:00 Introduction to Serotonin and HRT01:26 Understanding the Study on Serotonin and Osteoporosis04:44 The Impact of Serotonin on Bone Health09:27 Serotonin: The Misunderstood Hormone12:48 The Role of Hormones in Bone Density18:07 Chronic Stress and Its Effects on Bone Health20:32 Prevention and Understanding Osteoporosis25:18 The Importance of Continuous Learning in HRTFor practitioners who want to confidently grow their practice with guidance in TRT, HRT, and business strategy, find us below:- Nico's Daily Newsletter: ⁠⁠https://nicomislenp.kit.com/8050eeea5f⁠⁠(yes, it's daily... and yes, people stay subscribed)- Join HRT University: https://bit.ly/4twBb0D- Join the HRT University Facebook Group: ⁠⁠https://www.facebook.com/groups/1179376819949373/?ref=share&_rdr

Thinking about leaving your employed position and starting an independent practice? One of the biggest concerns for medical professionals is health insurance.In this episode, Nico Misleh sits down with Kevin and Joy Kincaid of Kincaid Solutions to discuss what really happens to your health coverage when you go independent. They break down common fears, explain the options available to private practice providers, and share how personalized guidance and transparency can make the transition far less overwhelming.If you are considering private practice, entrepreneurship, or stepping away from employer-sponsored benefits, this conversation will help you understand what is realistic, what is exaggerated, and how to move forward with confidence.

For practitioners who want to confidently grow their practice with guidance in TRT, HRT, and business strategy, find us below:- Nico's Daily Newsletter: ⁠⁠https://nicomislenp.kit.com/8050eeea5f⁠⁠(yes, it's daily... and yes, people stay subscribed)- Join HRT University: https://bit.ly/4twBb0D- Join the HRT University Facebook Group: ⁠⁠https://www.facebook.com/groups/1179376819949373/?ref=share&_rdr

In this episode, Nico Misleh discusses the critical role of thyroid in hormone replacement therapy (HRT), emphasizing that thyroid should not be viewed as an adjunct but as a foundational component. He critiques the conventional approach of using T4 monotherapy for hypothyroidism, highlighting the limitations of TSH as a diagnostic marker. Misleh advocates for combination therapy using T3 and T4, supported by recent studies showing its effectiveness in reducing risks of dementia and mortality. He encourages healthcare providers to adopt a pro-metabolic lens and to empower patients by moving away from outdated practices.Chapters00:00 The Importance of Thyroid in Hormone Replacement Therapy02:50 Monotherapy vs Combination Therapy for Hypothyroidism06:11 Understanding TSH and Its Limitations08:57 The Risks of T4 Monotherapy11:57 The Case for Combination Therapy14:47 Pro-Metabolic Lens on Thyroid Function18:10 The Role of T3 in Metabolism20:58 Empowering Patients and Providers24:03 Creating a New Standard in Thyroid TreatmentFor practitioners who want to confidently grow their practice with guidance in TRT, HRT, and business strategy, find us below:- Nico's Daily Newsletter: ⁠⁠https://nicomislenp.kit.com/8050eeea5f⁠⁠(yes, it's daily... and yes, people stay subscribed)- Join HRT University: https:https://bit.ly/4twBb0D- Join the HRT University Facebook Group: ⁠⁠https://www.facebook.com/groups/1179376819949373/?ref=share&_rdr

In this episode of the HRT University podcast, Nico Misleh discusses the complexities and misconceptions surrounding hormone replacement therapy (HRT), particularly for women over 60 or 10 years post-menopause. He emphasizes the importance of bioidentical hormones, the risks associated with synthetic hormones, and the necessity of early initiation of HRT for better health outcomes. Misleh advocates for patient empowerment through informed decision-making and shared understanding of the risks and benefits of HRT.Chapters00:00 Introduction to HRT University Podcast01:38 Understanding Hormone Replacement Therapy Risks06:45 Bioidentical Hormones vs. Synthetic Hormones12:15 The Importance of Early HRT Initiation14:09 Empowering Patients with HRT KnowledgeFor practitioners who want to confidently grow their practice with guidance in TRT, HRT, and business strategy, find us below:- Nico's Daily Newsletter: ⁠⁠https://nicomislenp.kit.com/8050eeea5f⁠⁠(yes, it's daily... and yes, people stay subscribed)- Join HRT University: https://bit.ly/4twBb0D- Join the HRT University Facebook Group: ⁠⁠https://www.facebook.com/groups/1179376819949373/?ref=share&_rdr

In this episode, Nico Misleh explores the significance of progesterone, often overlooked in discussions about hormones. He emphasizes the importance of understanding the relationship between progesterone and estrogen, the misconceptions surrounding hormonal terminology, and the clinical implications of these misunderstandings. Misleh advocates for a more comprehensive approach to hormone replacement therapy (HRT), highlighting the benefits of bioidentical progesterone over synthetic progestins. He calls for a movement to reclaim the narrative around hormonal health, ensuring that both practitioners and patients are educated about the true nature and benefits of hormones.Chapters00:00 Introduction to Progesterone01:30 The Importance of Progesterone02:59 Understanding Hormonal Relationships05:56 Estrogen vs. Progesterone Dynamics09:20 Progesterone's Role in Metabolism11:43 Misunderstandings in Hormonal Terminology15:15 The Distinction Between Progesterone and Progestins19:50 The Clinical Implications of Hormonal Confusion23:57 The Broader Impact of Progesterone29:09 Progesterone Beyond Reproductive Health32:34 The Misconception of Progesterone Necessity35:44 The Dangers of Progestins39:39 Reclaiming Hormone Replacement Therapy43:37 The Future of Hormonal HealthFor practitioners who want to confidently grow their practice with guidance in TRT, HRT, and business strategy, find us below:- Nico's Daily Newsletter: ⁠⁠https://nicomislenp.kit.com/8050eeea5f⁠⁠(yes, it's daily... and yes, people stay subscribed)- Join HRT University: https://bit.ly/4twBb0D- Join the HRT University Facebook Group: ⁠⁠https://www.facebook.com/groups/1179376819949373/?ref=share&_rdr

In this episode, Nico delves into the principles of functional medicine, contrasting it with traditional allopathic medicine. He emphasizes the importance of a systems approach, curiosity, and the need for healthcare providers to ask deeper questions about patient health. Misleh encourages practitioners to start integrating functional medicine into their practice and highlights the significance of mentorship and community in this journey. He also discusses the intersection of hormone replacement therapy (HRT) and functional medicine, advocating for a holistic view of patient care.Chapters00:00 Introduction to Functional Medicine02:47 The Shift from Allopathic to Functional Medicine06:13 Understanding the Systems Approach in Functional Medicine08:51 Curiosity and the Importance of Asking Why11:47 Practical Steps to Start Practicing Functional Medicine15:05 Integrating Hormone Replacement Therapy with Functional Medicine17:55 The Role of Curiosity in Medicine20:53 The Importance of Mentorship and Community24:05 Exploring the Complexity of Human Biology27:07 Conclusion and Call to ActionReady to build a brand and practice that is as unique as you are? Learn the clinical and business systems to create a thriving hormone optimization practice with The HRT Master Course. This program offers 30 ANCC-accredited credit hours and gives you the expert guidance you need to succeed. Start your journey at: https://hrtuniversity.com/hrtcourse/For practitioners who want to confidently grow their practice with guidance in TRT, HRT, and business strategy, find us below:- Nico's Daily Newsletter: ⁠⁠https://nicomislenp.kit.com/8050eeea5f⁠⁠(yes, it's daily... and yes, people stay subscribed)- Join HRT University: https://hrtuniversity.com/- Join the HRT University Facebook Group: ⁠⁠https://www.facebook.com/groups/1179376819949373/?ref=share&_rdr

In this episode, Nico Misleh shares why being willing to admit you are wrong is essential for growth in hormone replacement therapy and patient care. He reflects on early beliefs around male progesterone, how mentor influence and cognitive bias shape clinical decisions, and why evolving with new evidence leads to better outcomes for patients.This conversation explores humility in medicine, the importance of real-world clinical experience, and how providers can build trust by staying open to learning and improvement.Ready to build a brand and practice that is as unique as you are? Learn the clinical and business systems to create a thriving hormone optimization practice with The HRT Master Course. This program offers 30 ANCC-accredited credit hours and gives you the expert guidance you need to succeed. Start your journey at: https://hrtuniversity.com/hrtcourse/For practitioners who want to confidently grow their practice with guidance in TRT, HRT, and business strategy, find us below:- Nico's Daily Newsletter: ⁠⁠https://nicomislenp.kit.com/8050eeea5f⁠⁠(yes, it's daily... and yes, people stay subscribed)- Join HRT University: https://hrtuniversity.com/- Join the HRT University Facebook Group: ⁠⁠https://www.facebook.com/groups/1179376819949373/?ref=share&_rdr

In this episode, Nico Misleh breaks down the growing crisis of endocrine disrupting chemicals (EDCs) and their impact on hormonal health. From environmental toxins to modern medical blind spots, Nico explains why hormone replacement therapy should be viewed as a proactive solution—not a last resort—in today’s increasingly toxic world.
Ready to build a brand and practice that is as unique as you are? Learn the clinical and business systems to create a thriving hormone optimization practice with The HRT Master Course. This program offers 30 ANCC-accredited credit hours and gives you the expert guidance you need to succeed. Start your journey at: https://hrtuniversity.com/hrtcourse/For practitioners who want to confidently grow their practice with guidance in TRT, HRT, and business strategy, find us below:- Nico's Daily Newsletter: ⁠⁠https://nicomislenp.kit.com/8050eeea5f⁠⁠(yes, it's daily... and yes, people stay subscribed)- Join HRT University: https://hrtuniversity.com/- Join the HRT University Facebook Group: ⁠⁠https://www.facebook.com/groups/1179376819949373/?ref=share&_rdr

In this episode, Nico breaks down how healthcare providers can approach pricing conversations with confidence and clarity. From reframing cost discussions to understanding patient value, this episode explores why pricing isn’t sales — it’s part of patient care

Ready to build a brand and practice that is as unique as you are? Learn the clinical and business systems to create a thriving hormone optimization practice with The HRT Master Course. This program offers 30 ANCC-accredited credit hours and gives you the expert guidance you need to succeed. Start your journey at: https://hrtuniversity.com/hrtcourse/For practitioners who want to confidently grow their practice with guidance in TRT, HRT, and business strategy, find us below:- Nico's Daily Newsletter: ⁠⁠https://nicomislenp.kit.com/8050eeea5f⁠⁠(yes, it's daily... and yes, people stay subscribed)- Join HRT University: https://hrtuniversity.com/- Join the HRT University Facebook Group: ⁠⁠https://www.facebook.com/groups/1179376819949373/?ref=share&_rdr

In this episode, Nico Misleh discusses the benefits of Direct Primary Care (DPC) and the integration of Functional Medicine and Hormone Replacement Therapy (HRT) into practice. He emphasizes the importance of providing personalized care that goes beyond conventional methods, addressing the needs of patients seeking wellness rather than just treatment. The conversation highlights the potential for DPC providers to stand out by offering innovative solutions and the necessity of continuous education in Functional Medicine. Nico shares real-world applications and success stories, encouraging providers to embrace these practices for better patient outcomes and satisfaction.Ready to build a brand and practice that is as unique as you are? Learn the clinical and business systems to create a thriving hormone optimization practice with The HRT Master Course. This program offers 30 ANCC-accredited credit hours and gives you the expert guidance you need to succeed. Start your journey at: https://hrtuniversity.com/hrtcourse/For practitioners who want to confidently grow their practice with guidance in TRT, HRT, and business strategy, find us below:- Nico's Daily Newsletter: ⁠⁠https://nicomislenp.kit.com/8050eeea5f⁠⁠(yes, it's daily... and yes, people stay subscribed)- Join HRT University: https://hrtuniversity.com/- Join the HRT University Facebook Group: ⁠⁠https://www.facebook.com/groups/1179376819949373/?ref=share&_rdr