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In this Metabolic Classroom lecture, Ben explores the concept of anabolic resistance—the body’s reduced ability to build and maintain muscle in response to stimuli like protein intake and resistance training.

This phenomenon, often associated with aging, also affects individuals with obesity or a sedentary lifestyle. Because muscle health is directly tied to longevity, strength, insulin sensitivity, and independence, understanding and reversing anabolic resistance is critical for long-term metabolic health.

Dr. Bikman explains the key drivers of anabolic resistance: reduced anabolic hormone levels, impaired amino acid delivery, inflammation, and cellular changes such as insulin resistance and intramuscular lipid buildup. He emphasizes the central role of the mTOR signaling pathway in muscle protein synthesis, and how factors like age, obesity, and inactivity blunt this response—even when adequate nutrients and exercise are present.

The lecture ends with practical strategies to overcome anabolic resistance, including resistance training, high-leucine animal protein intake, creatine, omega-3s, vitamin D3, and even peptides. Ben stresses that building muscle isn’t just about looking good—it’s about preventing frailty, insulin resistance, and loss of independence. Resistance training is non-negotiable, and diet alone will never be enough to restore optimal muscle health.

Show Notes/References:

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