Kristen Hawkes' "Grandmother Hypothesis" provides a fascinating perspective on human evolution, menopause, and the unique social structures of humans. This theory posits that the long post-reproductive lifespan of women evolved because grandmothers played a critical role in supporting their descendants. By helping care for grandchildren and providing resources like food, grandmothers enhanced the survival and reproductive success of their families, which indirectly passed on their genes favouring longevity and cooperative behaviour. These contributions are thought to have driven distinct human traits, including increased brain size and social complexity, by encouraging intergenerational support and skill-sharing

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Kristen Hawkes PhD MS BA examines foraging and social strategies among hunter-gatherers to shed light on human evolution. Her work includes three projects focused on life history evolution, aging in captive chimpanzees, and understanding fire’s effects on foraging payoffs, all informed by ethnographic studies of the Ache in Paraguay and the Hadza in Tanzania. Observations suggest that men’s hunting primarily serves status competition rather than provisioning, while grandmothers play a crucial role in supporting their grandchildren, especially when mothers have more children. This aligns with the grandmother hypothesis, which explains human longevity and highlights differences between humans and chimpanzees, such as longer lifespans despite similar fertility rates and a male-biased sex ratio. Mathematical modeling underscores the impact of grandmothering on post-menopausal longevity, shorter birth intervals, and social behavior. Kristen Hawkes continues to collaborate on data collection and analysis to enhance understanding of ancestral foraging strategies and aging in captive chimpanzees.

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Dr. Darshan Shah reveals the shocking truth about the prevalence and danger of high Lp(a), citing personal anecdotes and expounding on how lifestyle changes, though beneficial, aren't always enough to mitigate the risks associated with this particular marker. The episode delves into modern testing methods, like the CLEERLY scan, and discusses revolutionary approaches such as Total Plasma Exchange (TPE) for managing Lp(a) levels and reducing overall toxic load. Get ready to be enlightened and empowered to take proactive steps in understanding and discussing these issues.

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Darshan Shah, MD, is a health and wellness specialist, board-certified surgeon, published author, and founder of Next Health, the world’s first and largest Health Optimization and Longevity clinic. Dr. Shah has performed over 20,000 surgical procedures, including trauma and complex reconstructive procedures. As a Longevity Medicine specialist, he advises patients on optimizing well-being and extending healthspan and lifespan. Dr. Shah earned his medical degree at 21, becoming one of the youngest doctors in the US, and completed his training at the prestigious Mayo Clinic. He opened medical centers, started companies, and published a book. His commitment to education and self-improvement earned him alumni status at Harvard Business School and Singularity University. Dr. Shah’s passion is educating people on adding healthspan to their lifespan, with over 100 speaking engagements and hosting the acclaimed podcast Extend.

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Colleen Cutcliffe explores the microbiome's role during menopause, focusing on the estrobolome and gut bacteria's interaction with estrogen. She emphasizes the importance of gut health, particularly Acromantia, and discusses the negative impacts of birth control pills and antibiotics. Along with Dr. Mindy, they highlight essential microbes, dietary changes, and probiotics for wellness, and examine the long-term effects of weight loss drugs on the microbiome. Lastly, they stress measuring health through energy levels and the four pillars of well-being: nutrition, exercise, mental health, and the microbiome.

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Colleen Cutcliffe is the Chief Executive Officer and co-founder of Pendulum. She has more than 15 years of experience leading and managing biology teams in academia, pharmaceuticals, and biotechnology. Prior to starting Pendulum, Colleen was the senior manager of biology at Pacific Biosciences and a scientist at Elan Pharmaceuticals. Colleen completed her postdoctoral studies at Northwestern’s Children’s Memorial Hospital. Colleen received her Ph.D. in Biochemistry and Molecular Biology from Johns Hopkins University and her B.A. in Biochemistry from Wellesley College.

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Who says you need pricey weight loss drugs to feel fabulous? Dr. Mindy shows how small habits, like getting enough Vitamin D and walking 4,000 steps a day, can transform your body and mind! Join the movement to a healthier you. Because, after all, middle-age doesn't have to mean giving up on your weight goals!

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Dr. Mindy Pelz is joined by Caroline Alan, co-founder of Beam Minerals, to explore the essential role minerals play in balancing the body and enhancing health. They discuss how to choose the right minerals, the benefits of fulvic and humic acids, and how minerals support fasting, detoxification, and recovery from your holiday indulgences. Caroline shares tips for a three-day water fast, recipes for mineral-rich mocktails, and practical ways to replenish your body during Dry January. Tune in to learn how minerals can transform your health journey!

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Caroline Alan (The Mineral Geek) is a health survivor and mineral enthusiast. Coming from a career in the corporate world, like many, Caroline found herself struggling physically, mentally and energetically.  As a result of her journey back to health and years of deep research, Caroline has become devoted to educating people about how minerals operate in the body, why we need to supplement our mineral intake and the benefits of natural humic and fulvic, plant-based mineral substances for replenishment in the body. Caroline is also the Co-Founder and CEO of BEAM Minerals Inc.

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Rachel Hollis dives into the challenges of staying true to oneself in a world full of filtered images and societal expectations, sharing heartfelt stories and moments of self-discovery. Rachel reveals her struggles with maintaining her mission-hearted approach and how she manages her public persona while undergoing personal transformations. Filled with laughter, tears, and empowering insights, this episode is a reminder for women to embrace their true selves and trust their inner wisdom.

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Rachel Hollis laid the foundation for her lifestyle brand and media company with the same unfiltered honesty and staunch inclusivity that made her a two-time #1 New York Times bestselling author. Hollis connects with a highly engaged and growing global audience who treasures her transparency and optimism. She is one of the most sought-after motivational speakers, plays host to one of today’s top podcasts, and is a proud working mama of four who uses her platform to empower and embolden women around the world. Rachel calls Texas home; more specifically, the Hill Country just outside of Austin.

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Ready to boost your health with a simple walk? Discover how 20 minutes a day can improve metabolism, reduce stress, and support weight loss. Perfect for women embracing life's next chapter. This episode highlights the benefits of regular walking, focusing on hormonal balance and long-term weight loss. Citing studies from the *Journal of Nutrition* and the *American Journal of Health Promotion*, Dr. Mindy notes that consistent walking leads to sustainable weight loss and overall health improvement. It also introduces 'rucking'—walking with a weighted vest—as a way to enhance these benefits. 

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Are you worried about aging and memory health? Join us as we dive into strategies that empower women in their 50s to live healthy, vibrant lives while reducing the risk of dementia and Alzheimer’s. In this episode, Dr. Heather Sandison discusses cognitive health strategies to combat dementia and Alzheimer's. This episode dives into the early signs of these neurodegenerative diseases, emphasizing the importance of lifestyle interventions, such as diet, exercise, and sleep. Dr. Sandison also explores scientific misconceptions around existing treatments, focusing on the benefits of ketosis, metabolic health, and innovative treatments. Dr. Sandison shares her professional insights and practical tips for those caring for aging parents, as well as providing guidance on the path to optimizing brain health at any age.

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Dr. Heather Sandison is the NYT bestselling author of “Reversing Alzheimer’s: The New Toolkit to Improve Cognition and Protect Brain Health”. She is a renowned naturopathic doctor specializing in neurocognitive medicine and the founder of Solcere Health Clinic, a premier brain optimization clinic based in San Diego, and Marama, a residential program changing memory care to memory recovery. Dr. Sandison is dedicated to supporting those suffering with dementia and is the primary author of peer-reviewed research published in the Journal of Alzheimer’s Disease. She is shattering common misconceptions about Alzheimer’s teaching lifestyle change protocols that keep your brain sharp at any age.

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Did you know the oils in your kitchen could be sabotaging your health? In this episode, Dr. Mindy sits down with Dr. Cate Shanahan to uncover the surprising dangers of seed oils and how they impact your metabolism, cravings, and overall wellness. Learn why these oils are more harmful than sugar, how to avoid them (even when dining out), and the benefits of a 2-week seed oil-free challenge. Plus, discover practical tips for nourishing your body with the right fats and carbs. It’s time to take control of your health and feel your best!

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Catherine Shanahan, MD, is a board-certified family physician specializing in the promotion of health and reversal of disease using traditional food as a first line of treatment. She has studied biochemistry and genetics at Cornell University and ethnobotany at the National Tropical Botanical Garden in Kauai, Hawaii. In 2010, she was invited to relocate to the mainland to direct The Bedford Center of Nutritional Medicine, the first clinic of its kind in the country to bring farmers and chefs together with exercise therapists, massage therapists, and dietitians to form a multidisciplinary patient care team. 

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In this special solo episode, Dr. Mindy introduces a simple morning habit to help burn stubborn fat: spending 10 minutes in direct early morning sunlight to boost vitamin D levels. She explains that weight loss is more about hormonal balance, specifically insulin and cortisol, rather than calorie counting. This episode also includes a Q&A segment addressing common weight loss and fasting concerns from the Resetter audience. 

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