Why do hormonal fluctuations affect some individuals more than others? How does progesterone's metabolite allopregnanolone traverse the blood-brain barrier to influence mood? And what role do neurotransmitters like serotonin and GABA play in the manifestation of PMDD? We'll be dissecting these questions and give you an in-depth understanding of PMDD's multifaceted nature.

Disclaimer: Dr. Tara Harding is a Doctor of Nursing Practice and licensed Family Nurse Practitioner (FNP-C). This content is for educational purposes only and does not constitute medical advice. Always consult your own healthcare provider for diagnosis and treatment tailored to your individual needs.