Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler

Guests: Rebecca Dutch and Christiane Wobus

On this episode of TWiV, which was recorded before a large enthusiastic audience at the annual meeting of the American Society for Virology, Vincent, Rich, and Kathy speak with Rebecca and Christiane about their work on metapneumoviruses and noroviruses.

• TWiV 143 with Stephanie Karst
• American Society for Virology
• Mouse model for human norovirus (mBio)
• Paramyxovirus fusion (Viruses)
• Photo credit: Matt Evans

Kathy - Shuffling cardsVincent - Dave Bhella - Electron cryomicroscopyRich - Seven-year postdoc

Judi - Reading for science literacy

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Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler

The complete TWiV team talks about how two different viruses shape the evolution of an essential housekeeping protein.

• Dual virus-host arms race (PLoS Biology)
• Dual virus-receptor duel (see comments - virology blog)
• Ferritin and transferrin (Protein Data Bank)
• Money for nothing (YouTube)
• Letters read on TWiV 242

Dickson - Mantid imagesKathy - No email? (phd comics)Alan - The turbid plaqueVincent - AAM Faq: West Nile VirusRich - Science is awesome

Luis - Public Health Image LibraryStephen - Hopkins closes graduate science-writing program

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Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler

Vincent, Alan, Rich and Kathy review how human placental trophoblasts confer viral resistance via exosome-mediated delivery of microRNAs, and isolation of the first human influenza virus in 1933.

Links for this episode:

• Human placental trophoblasts confer viral resistance (PNAS)
• Placental circulation (Wikipedia)
• Ovum in uterine decidua (Wikipedia)
• A virus obtained from influenza patients (Lancet)
• 80 years ago today (the guardian)
• Influenza: Exposing the true killer (J Exp Med)
• Letters read on TWiV 239

Matt - The Kid Should See ThisAlan - Cassini to photograph Earth Vincent -Cockroaches! (YouTube)Rich - Sydney Brenner (Web of Stories)

Joe - Grand challenges in science education (Science)Mark - Weather Underground

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Host: Vincent Racaniello

Guests: Markus Thali and Jason Botten

Vincent travels to the University of Vermont to talk with Markus and Jason about their work on HIV, influenza virus, arenaviruses and hantaviruses.

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Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Matt Frieman

Matt joins Vincent, Alan, and Rich to summarize what we know and what we do not know about the MERS coronavirus.

• MERS-CoV update (WHO)
• MERS-CoV evolution (epidemic)
• Sick camel linked to MERS-CoV death (7Days)
• MERS-CoV hospital outbreak (NEJM)
• MERS-CoV French hospital cluster (Lancet)
• MERS-CoV family cluster (NEJM)
• Matt on MERS-CoV on the Voice of Russia
• Letters read on TWiV 239

Matt - The Kid Should See ThisAlan - Cassini to photograph Earth Vincent -Cockroaches! (YouTube)Rich - Sydney Brenner (Web of Stories)

Ebrahim - Virus Hunter by CJ Peters and Mark Olshaker

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Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler

Vincent, Rich and Kathy discuss mechanisms of protein synthesis and regulation in virus-infected cells.

• Slides for this episode (pdf)
• T7 ribosomal binding sites (CSH Symp Quant Biol)
• Tinkering with translation (CSH Persp)
• Translation at nexus of infection and immunity (Cell Host Microbe)
• Viral subversion of protein synthesis machinery (Nat Rev Micr)

Kathy - Vaccine-preventable outbreaksRich - To Catch a Virus by John Booss and Marilyn J. AugustVincent - This is Water by David Foster Wallace

Jon - Confessions of a converted lecturer by Eric MazurPeter - FameLab

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Hosts: Vincent Racaniello and Rich Condit

Guest: Michael Emerman

Vincent and Rich recorded this episode at the Fred Hutchinson Cancer Research Center in Seattle, WA, where they met up with Michael to talk about his work on the molecular and evolutionary basis of HIV replication and pathogenesis.

• Ancient origins of SIV (PLoS Path)
• Paleovirology (PLoS Biology)
• Harmit Malik on TWiV 205
• Sara Sawyer on TWiV 193

Molly - Facts in the case of Dr. Andrew Wakefield

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Hosts: Vincent Racaniello, Alan Dove, and Kathy Spindler

Vincent, Alan and Kathy review novel approaches to preventing influenza virus infection.

• Ultraprotective influenza vaccine in mice (PNAS)
• Vectored immunoprophylaxis of influenza in mice (Nat Biotech)
• Intranasal antibody gene transfer protects agains influenza (Sci Transl Med)
• Estimating influenza associated deaths (CDC)
• Multistate HAV outbreak (CDC)
• Subscribe to Microbeworld video (YouTube)
• Save podcasting (EFF)
• Letters read on TWiV 236

Alan - Psychology of antivaccinationistsVincent - Virology on CourseraKathy - Meteorites through the ages

Basel - Self-medication in animalsSheryl - Noadi's artFelicity - Survival of the Sickest by Sharon Moalem

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Hosts: Vincent Racaniello and Rich Condit

Guests: Dave Evans, Stan Lemon, and Lorne Tyrrell

Vincent and Rich recorded this episode before an audience at the 2nd Li Ka Shing Institute of Virology Symposium at the University of Alberta, where they spoke with Dave, Stan, and Lorne about their work on poxvirus vaccines and recombination, an enveloped picornavirus, antivirals against hepatitis B and C viruses, and supporting virology research in Alberta.

• Li Ka Shing Institute of Virology
• Alberta Heritage Foundation for Medical Research
• Raised on a farm (YouTube)
• Vaccinia virus strains in Dryvax vaccine (J Virol)
• Vaccinia DNA polymerase and recombination (J Virol)
• Picornavirus hijacks cell membrane (Nature)

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Hosts: Vincent Racaniello and Kathy Spindler

Guests: Nels Elde and Tom Shenk

Vincent and Kathy recorded this episode before an audience at the 2013 General Meeting of the American Society for Microbiology in Denver, Colorado, where they spoke with Nels and Tom about their work on the evolution of virus-host conflict and how viruses influence the cell metabolome.

• A cross-species view on viruses (Curr Op Virol)
• Pox has got a squeeze box (TWiV 198)
• Saturated fatty acids needed for CMV (PLoS Path)
• CMV and HSV metabolomes differ (PLoS Path)
• Video of this episode - view at YouTube

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