Host: Vincent Racaniello

Guests: Melissa Churchill, Alex Khromykh, Gilda Tachedjian, and Paul Young

Vincent visits Melbourne, Australia and speaks with Melissa, Alex, Gilda, and Paul about their work on HIV infection of the central nervous system, West Nile virus, microbicides for HIV, and the Koala retrovirus.

• Where does HIV hide? (Curr Op HIV AIDS)
• Subgenomic flavivirus RNA (Viruses)
• Vaginal lactic acid and HIV (J Antimicro Chem)
• Koala retroviruses (Retrovirology)
• Coming soon - Video of this episode at YouTube

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Host: Vincent Racaniello

Guests: Wade Blair, Matt Dickson, Nicole Kallewaard-Lelay, and Ken Miller

Vincent visits Medimmune and speaks with Wade, Matt, Nicole, and Ken about why they work in industry and their daily roles in a biotechnology company.

• Medimmune, LLC
• Medimmune on Twitter
• Medimmune history and products
• Video of this episode - view at YouTube

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Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler

Guests: Clodagh O'Shea and Ron Fouchier

Vincent, Rich, and Kathy and their guests Clodagh and Ron recorded this episode at the 33rd annual meeting of the American Society for Virology at Colorado State University in Ft. Collins, Colorado.

• Viral polymer that inactivates tumor suppressors (Cell)
• Mutations driving airborne transmission of influenza H5N1 virus (Cell)
• Transmission of influenza H7N1 virus in ferrets (J Virol)
• Ron Fouchier on TWiV #177
• Photo credit: Matt Evans
• Thanks to David Quammen for the title
• Video of this episode - view at YouTube

Rich - No sexual transmission of HCV (Am J Gastro)Vincent - Made with code (blog post)Kathy - Beautiful math images (and 50 Visions of Mathematics)

Jon - Advances in Life Sciences winners (YouTube)Dave - Adam Ruben

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Host: Vincent Racaniello

Guests: Janet Butel and Rick Lloyd

Vincent meets up with Janet Butel and Rick Lloyd at Baylor College of Medicine to talk about their work on polyomaviruses and virus induced stress.

• SV40 microRNAs (PLoS Path)
• SV40 seroprevalence (J Infect)
• Viruses and stress granules (PLoS Path)
• Viral inhibition of stress granule formation (Cell Host Micr)
• Video of this episode - view below or at YouTube

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Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Kathy Spindler

Vinny and the capsids answer listener questions about the definition of life, state vaccination laws, the basic science funding problem, viral ecology, inactivation of viruses by pressure, and much more.

• Varun's research poll
• Letters read on TWiV 289

Alan - The Science of Good Cooking Vincent - The Shooter Report (pdf)Kathy - Daily overviewDickson - Girl rising

Johnye - Ri channelRicardo - Open spin microscope (Nikon gallery, plans)Chris - The microbiome game

Send your virology questions and comments (email or mp3 file) to [email protected]

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler

The Twivsters discuss how reverse transcriptase encoded in the human genome might produce DNA copies of RNA viruses in infected cells.

• Should variola virus be destroyed? (poll at virology blog)
• DNA complementary to non-retroviral RNA viruses (Sci Rep)
• Integration of arenavirus DNA into cell genome (virology blog)
• Infectious respiratory syncytial DNA (PNAS)
• Tysabri and PML
• JC and PML (J Imm Res)
• Igor Koralnik laboratory
• Jean-Luc Doumont (Kathy's pick, TWiV 268)
• Bullet points kill (TED)
• Letters read on TWiV 288

Rich - LuvalampsAlan - ExperimentVincent - American Society for Virology on FacebookKathy - LEGO female scientistsDickson - The Oldest Living Things in the World by Rachel Sussman

Basel - A Treatise on the small-pox and measles by Abu-Bakr Al-Razi

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Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Kathy Spindler, and Matt Frieman

Matt updates the TWiV team on MERS-coronavirus, and joins in a discussion of whether we should further regulate research on potentially pandemic pathogens.

• MERS stories at CIDRAP
• MERS at CDC
• MERS in the US (CDC)
• MERS-CoV map
• MERS-CoV infection after camel exposure (EID)
• MERS-CoV in dromedaries from Egypt, Sudan, Ethiopia (EID)
• MERS-CoV antivirals (one, two, three, four)
• Experiments with novel potential pathogens (PLoS Med)
• Unacceptable risks (Bull Atom Sci)
• TWiX Bingo (thanks, Mark!)
• Letters read on TWiV 287

Matt - Forgive me, scientistsAlan - Do not linkVincent - bioRxivKathy - Snail photographsDickson - Solar roadways

Daniel - Benz Biome concept car

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Hosts: Vincent Racaniello and Alan Dove

Guests: Julie Pfeiffer and Paul Duprex

Vincent and Alan meet up with Julie and Paul at the General Meeting of the American Society for Microbiology in Boston, to talk about their work on the pathogenesis of poliovirus and measles virus.

• Threading the NEIDL (YouTube)
• Transmission of measles virus from macaques (J Gen Virol)
• Tropism of green measles virus in macaques (J Virol)
• Intestinal microbiota promote enteric virus replication (Science)
• Bacterial LPS enhances poliovirus stability (Cell Host Micr)
• Video of this episode - view below or at YouTube

Vincent - ASM Live 2014Alan - I will not follow the herdPaul - Invisible ThreatJulie - The importance of stupidity in biological research

Neil - WEHI movies and VIZBI

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Host: Vincent Racaniello

Guests: XJ Meng and Sarah McDonald

Vincent meets up with XJ and Sarah at Virginia Tech to talk about their work on viruses of swine and rotaviruses.

• Hepatitis E virus (Int J Env Res Pub Health)
• Porcine and human anelloviruses (J Virol)
• Origin of porcine epidemic diarrhea virus in US (mBio)
• Distinguishing rotaviruses (J Virol)
• Molecular epidemiology of rotaviruses (J Virol)
• Core domains in rotavirus polymerase encapsidation (J Gen Virol)

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Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Kathy Spindler

The TWiV team discusses how skin scarification promotes a nonspecific immune response, and whether remaining stocks of smallpox virus should be destroyed.

• Skin scarification protects against vaccinia virus disease (J Virol)
• Smallpox research agenda (PLoS Path)
• WHO report on variola research (pdf)
• Review of smallpox research program for WHO (pdf)
• How I record my lectures (virology blog)
• Letters read on TWiV 284

Rich - EPCOTVincent - Medical BiotechnologyKathy - Alan Alda interview and Flame Challenge winnerDickson - NASA live from space

Nicola - 50 cent microscope (be a beta tester)Jon - Camtasia Studio

Send your virology questions and comments (email or mp3 file) to [email protected]