Vincent travels to the University of Texas in Austin to speak with speak with Jason McLellan about his career and his research on the SARS-CoV-2 spike protein, including the effect of adding two proline residues, its effect on other viral spike glycoproteins, and general approaches to vaccine design.

Hosts: Vincent Racaniello and Rich Condit

Guest: Jason McLellan

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• MicrobeTV Discord Server
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• Become a member of ASV (asv.org)
• The New City by Dickson Despommier
• Prefusion-stabilized SARS-CoV-2 spikes (Science)
• Structure-based vaccine design (Curr Opin Immunol)
• Prefusion-stabilized SARS-CoV-2 S2-only antigen (Nat Comm)
• Stabilized coronavirus spike stem elicits broadly protective antibody (Cell Rep)
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your virology questions and comments to [email protected]

In his weekly clinical update, Dr. Griffin reviews recent statistics on the circulation of measles and influenza before addressing Vincent's comment on measles inclusion in the clinical respiratory PCR panel, the latest statistics on influenza and COVID-19 circulation, if inflammatory cytokines and anti-viral antibody function synergistically, if administration of peptide agonists of the glucagon-like or sodium-glucose pump can reduce disease severity, restates the guidelines for spring administration of COVID vaccines boosters, discusses the emergency use application of a pre-exposure prophylactic. revised guidelines for how to treat respiratory viral infection guidelines by the CDC, continues to dispel the myth of viral rebound, revised guidelines for SARS-CoV-2 treatment and how to treat respiratory viral infections, when to use steroids and the benefits of convalescent plasma, what do when healthcare workers succumb to SARS-CoV-2 infection, if remdesivir or paxlovid can reduce cardiovascular adverse events and the first finding of the two-year longitudinal study on long COVID. For more information about this body of work, listen to TWiV 1088.

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• Measles tracking (CDC)
• What happens when measles is included in commercial syndromic PCR panels (MMWR)
• Influenza/flu surveillance (CDC)
• Influenza on the Texas ranch (Statnews)
• Sequence analysis of highly pathogenic avian influenza from Texas (CDC)
• Influenza/flu map (CDC)
• COVID-19 hospital admissions (CDC)
• COVID-19 national trend (CDC)
• COVID-19 wastewater testing (biobot)
• Variant tracker (CDC)
• Variant hospital admissions (CDC)
• Can inflammatory cytokines and antibodies play nicely to prevent COVID-19 mortality (IJID)
• Association of GLP-1RA and SGLT-2i to modulate COVID-19 severity (Diabetes Therapy)
• Spring COVID-19 booster recommendations (CIDRAP)
• Older adult spring booster available (CDC)
• Advisory committee for immunization practices spring 2024 COVID-19 boosters (CDC)
• EUA for pemgarda (FDA)
• CDC Quarantine guidelines (CDC)
• NIH COVID-19 treatment guidelines (NIH)
• Molnupiravir safety and efficacy (JMV)
• Convalescent plasma recommendation for immunocompromised (IDSociety)
• CDC Quarantine guidelines (CDC)
• NIH COVID-19 treatment guidelines (NIH)
• What do when your heathcare provider is infected with SARS-CoV-2 (CDC)
• Managing healthcare staffing shortages (CDC)
• Steroids,dexamethasone at the right time (OFID)
• Anticoagulation guidelines (hematology.org)
• Remdesivir and cardiac adverse events in hospitalized patients (CID)
• Long COVID evidence based review TWiV shout out (TWiV 1088)
• Longitudinal study reveals long COVID symptom peaks and nadirs (OFID)
• Paxlovid lowers risk of cardiovascular disease in COVID-19 patients with autoimmune disease (BMC Medicine)
• Contribute to our ASTMH fundraiser at PWB
• Letters read on TWiV 1102
• Dr. Griffin's COVID treatment summary (pdf)
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to [email protected]

Paul Offit joins TWiV to discuss his latest book, "Tell Me When It's Over", an insider's guide to deciphering COVID myths and navigating our post-pandemic world.

Hosts: Vincent Racaniello, Dickson Despommier, and Brianne Barker

Guest: Paul Offit

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• MicrobeTV Discord Server
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• The New City by Dickson Despommier
• Tell Me When It's Over by Paul Offit
• Navigating the U.S. Immigration System (webinar)
• Classifying Viral Subspecies (Workshop)
• Options XII for the Control of Influenza (Meeting)
• Letters read on TWiV 1101
• Timestamps by Jolene. Thanks!

Dickson – Astronomers Unveil Strong Magnetic Fields Spiraling at the Edge of Milky Way's Central Black Hole Brianne – Inside the AI Competition That Decoded an Ancient Herculaneum Scroll Vincent – biotech.symposium on Instagram

Intro music is by Ronald Jenkees

Send your virology questions and comments to [email protected]

In his weekly clinical update, Dr. Griffin reviews recent statistics on the circulation of measles influenza and SARS-CoV-2, before discussing the development of new monoclonal antibody therapy, if vaccines and antivial drugs can used effectively together. revised guidelines for how to treat respiratory viral infection guidelines by the CDC, continues to dispel the myth of viral rebound including that after administration of the "oral remdesivir", revised guidelines SARS-CoV-2 treatment and how to treat respiratory viral infections, when to use steroids and the benefits of convalescent plasma, what do when healthcare workers succumb to SARS-CoV-2 infection, if one can predict the loss infectivity of healthcare workers with mild COVID-19 disease and the dynamics of household transmission of the virus in children.

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• Measles tracking (CDC)
• Influenza/flu surveillance (CDC)
• Influenza/flu map (CDC)
• COVID-19 hospital admissions (CDC)
• COVID-19 national trend (CDC)
• COVID-19 wastewater testing (biobot)
• Variant tracker (CDC)
• Variant hospital admissions (CDC)
• What new monoclonal antibody therapy? (FDA)
• A New pre-exposure prophylaxis for COVID-19? (Invivyd)
• CDC Quarantine guidelines (CDC)
• NIH COVID-19 treatment guidelines (NIH)
• Really COVID-19 rebound after Nirmatrelvir-ritonavir treatment? (JAMA Network Open)
• Can vaccines and antiviral be effective for COVID-19 together (International Journal of Infectious Diseases)
• Molnupiravir safety and efficacy (JMV)
• Convalescent plasma recommendation for immunocompromised (IDSociety)
• CDC Quarantine guidelines (CDC)
• NIH COVID-19 treatment guidelines (NIH)
• What do when your heathcare provider is infected with SARS-CoV-2 (CDC)
• Managing healthcare staffing shortages (CDC)
• Can loss of infectivity among healthcare works with mild and recurrent COVID-19 be predicted (CID)
• Household transmission dynamics in children with asymptomatic infection (CID)
• Steroids,dexamethasone at the right time (OFID)Anticoagulation guidelines (hematology.org)
• Contribute to our ASTMH fundraiser at PWB
• Letters read on TWiV 1098
• Dr. Griffin's COVID treatment summary (pdf)
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to [email protected]

Vincent travels to the University of Heidelberg to speak with Volker Lohmann about his career and the research of his laboratory on hepatitis C virus, hepatitis A virus, and norovirus.

Host: Vincent Racaniello

Guests: Volker Lohmann

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• MicrobeTV Discord Server
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• The New City by Dickson Despommier
• HCV human challenge studies (Lancet Gastro Hepatol)
• Comparison of HCV and HAV infections (J Hepatol)
• HCV cell culture systems (J Med Chem)

Intro music is by Ronald Jenkees

Send your virology questions and comments to [email protected]

In his weekly clinical update, Dr. Griffin deep dives into recent domestic and global measles and mpox outbreaks, before reviewing recent statistics on the circulation of respiratory syncytial virus, influenza and SARS-CoV-2, discussing revised guidelines for how to treat respiratory viral infection guidelines by the CDC, revised guidelines SARS-CoV-2 treatment and how to treat respiratory viral infections, continues to dispel the myth of viral rebound, when to use steroids and the benefits of convalescent plasma, what do when healthcare workers succumb to SARS-CoV-2 infection, how much oxygen is necessary for effective treatment of severe disease, how COVID-19 effects the cardiovascular system of children and adolescents with long COVID and how iron metabolism may be altered during long COVID.

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• Measles tracking (CDC)
• Measles in Cook County (MMWR)
• Gaps in measles vaccination drives viral surges (Infectious Disease Advisor)
• Misinformation impacts public health? Seriously? (ID Society)
• CDC alert for global and domestic measles cases and outbreaks (CDC)
• Mpox in Kamituga associated with outbreak in DRB (Eurosurviellance)
• Mpox in US, 2023 (MMWR)
• Mpox in DRC, 2024 (reliefweb)
• CDC guidance for respiratory diseases, COVID antiviral & emergence of clade I mpox (ID Society)
• ~5% of infected dead from mpox (CIDRAP)
• First cases of mpox in Republic of Congo (AP News)
• Respiratory disease surveillance (CDC)
• RSV surveillance (CDC)
• RSV national trend (CDC)
• Influenza/flu surveillance (CDC)
• Influenza/flu map (CDC)
• COVID-19 hospital admissions (CDC)
• COVID-19 national trend (CDC)
• COVID-19 wastewater testing (biobot)
• Variant tracker (CDC)
• Variant hospital admissions (CDC)
• Multisystem inflammatory syndrome in children 2023 (MMWR)
• Guidance for COVID-19 in children and adolescents (JPIDS)
• CDC Quarantine guidelines (CDC)
• NIH COVID-19 treatment guidelines (NIH)
• Molnupiravir safety and efficacy (JMV)
• CDC Quarantine guidelines (CDC)
• NIH COVID-19 treatment guidelines (NIH)
• What do when your heathcare provider is infected with SARS-CoV-2 (CDC)
• Managing healthcare staffing shortages (CDC)
• Steroids,dexamethasone at the right time (OFID)
• Anticoagulation guidelines (hematology.org)
• High/low oxygenation target (JAMA)
• How much oxygen is needed (JAMA)
• Orthostatic intolerance in long COVID and healthy volunteers (JMV)
• Autonomic cardiac function in children and adolescents with long COVID (European Journal of Pediatrics)
• Long COVID iron dysregulation and inflammatory stress erythropoiesis (Nat Imm)
• Contribute to our ASTMH fundraiser at PWB
• Letters read on TWiV 1098
• Dr. Griffin's COVID treatment summary (pdf)
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to [email protected]

Vincent travels to the fifth Giant Virus Meeting in Tegernsee, Germany and speaks with Sheree Yau and Victoria Queiroz about their research on picoeukaryotes (tiny algal cells) and their viruses, pithoviruses, and an educational kit for virology classes.

Host: Vincent Racaniello

Guests: Sheree Yau and Victoria Queiroz

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• MicrobeTV Discord Server
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• The New City by Dickson Despommier 8:16
• Virophage control of antarctic algal host-virus dynamics (PNAS)
• Timestamps by Jolene. Thanks!
• Virus-host coexistence in phytoplankton through the genomic lens (Sci Adv)
• Two groups of pithoviruses (J Virol)
• Educational toolkit for virology classes (J Virol)

Intro music is by Ronald Jenkees

Send your virology questions and comments to [email protected]

In his weekly clinical update, Dr. Griffin highlights measles outbreaks throughout the continental US, reviews recent statistics on the circulation of respiratory syncytial virus, influenza and SARS-CoV-2 before discussing if vaccination protected children from the development of long COVID or cardiovascular diseases associated with virus infection, revised guidelines SARS-CoV-2 treatment and how to treat respiratory viral infections, continues to dispel the myth of viral rebound, when to use steroids and the benefits of convalescent plasma, how COVID-19 effects the autonomic nervous system, and if nirmatrelvir-ritonavir protects against adverse cardiovascular effects following SARS-CoV-2 infection.

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• Measles everywhere (CDC)
• Respiratory disease surveillance (CDC)
• RSV surveillance (CDC)
• RSV national trend (CDC)
• Estimating niresevimab effectiveness for infants (MMWR)
• More than 100 children died of influenza (NBS News)
• Influenza/flu surveillance (CDC)
• Influenza/flu map (CDC)
• COVID-19 hospital admissions (CDC)
• COVID-19 national trend (CDC)
• COVID-19 wastewater testing (biobot)
• Variant tracker (CDC)
• Variant hospital admissions (CDC)
• Did the vaccine protect children against Long COVID (Pediatrics)
• Did COVID-19 vaccination impact cardiovascular diseases? (Nat Comm)
• CDC Quarantine guidelines (CDC)
• NIH COVID-19 treatment guidelines (NIH)
• Molnupiravir safety and efficacy (JMV)
• Convalescent plasma recommendation for immunocompromised (IDSociety)
• Updated respiratory infection guidelines (CDC)
• What do when your heathcare provider is infected with SARS-CoV-2 (CDC)
• Managing healthcare staffing shortages (CDC)
• Steroids,dexamethasone at the right time (OFID)
• Anticoagulation guidelines (hematology.org)
• Long COVID trial for autonomic nervous system dysfunction (NIH)
• Nirmatrelvir-ritonavir impact on myocardial injury and long-term cardiovascular outcomes in COVID-19 hospitalized patients (Cardiovascular Drugs and Therapy)
• Contribute to our ASTMH fundraiser at PWB
• Letters read on TWiV 1096
• Dr. Griffin's COVID treatment summary (pdf)
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to [email protected]

TWiV reviews heterosexual transmission of clade I Mpox virus, continued circulation of oropouche virus in South America, herpesviruses in South American fur seals and sea lions, sex-specific differences in physiological responses to SARS-CoV-2 infection, underdetected dispersal and extensive local transmission drove the 2022 mpox epidemic, and a humanized mouse model for adenovirus-associated virus gene therapy.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Angela Mingarelli

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• MicrobeTV Discord Server
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• Become a member of ASV (asv.org)
• The New City by Dickson Despommier
• Heterosexual transmission of clade I Mpox virus (Emerg Inf Dis)
• Continued circulation of oropouche virus (PAHO and WHO)
• Herpesviruses in fur seals and sea lions (PLoS One)
• Sex-specific effects of SARS-CoV-2 infection (PLoS One)
• Drivers of 2022 Mpox virus epidemic (Cell)
• How AAV gene transfer works (YouTube)
• Humanized mouse model for AAV gene therapy (Nat Comm)
• Timestamps by Jolene. Thanks!

Dickson – Baden Powell – Manha de Carneval Angela – Upcoming Health & Fitness podcast from MicrobeTV Rich – Mark Smith Photography Alan – OpenVertebrate (and Science article on it) Vincent – Veterinary apparel for the veterinary nerd

Anne – Why Reed Jobs is betting on cancer innovations

Intro music is by Ronald Jenkees

Send your virology questions and comments to [email protected]

In his weekly clinical update, Dr. Griffin reviews recent statistics on the circulation of respiratory syncytial virus, influenza and SARS-CoV-2 before discussing revised guidelines for how to treat respiratory viral infection guidelines by the CDC, effectiveness of the new SARS-CoV-2 vaccines and the combination of vaccination and antiviral therapy against the development of disease, continues to dispel the myth of viral rebound, how to pay for paxlovid, the lack of evidence supporting ivermectin as an antiviral drug, when to use steroids and the benefits of convalescent plasma, how COVID-19 affects cognitive function and the effect of long COVID and how healthcare works have difficulty making the proper diagnosis for long COVID even using a questionnaire.

Become a patron of TWiV!

• Respiratory disease surveillance (CDC)
• RSV surveillance (CDC)
• RSV national trend (CDC)
• Influenza/flu surveillance (CDC)
• Influenza/flu map (CDC)
• COVID-19 hospital admissions (CDC)
• COVID-19 national trend (CDC)
• COVID-19 wastewater testing (biobot)
• Variant tracker (CDC)
• Variant hospital admissions (CDC)
• What to do when you are sick with a respiratory virus (CDC)
• Basis for respiratory virus guidance (CDC)
• Effectiveness of updated COVID-19 vaccines (MMWR)
• CDC Quarantine guidelines (CDC)
• NIH COVID-19 treatment guidelines (NIH)
• Synergy or additive protection with vaccination and oral antivirals (CID)
• To rebound or to not rebound (MMWR)
• Know your COVID-19 tools (ESMED)
• How to pay for Paxlovid (PAXCESS)
• Molnupiravir safety and efficacy (JMV)
• Still talking about Ivermectin? (Journal of Infection)
• Convalescent plasma recommendation for immunocompromised (IDSociety)
• Steroids,dexamethasone at the right time (OFID)
• Anticoagulation guidelines (hematology.org)
• Cognition and memory after COVID-19 (NEJM)
• Loss of IQ after SARS-CoV-2 infection (CIDRAP)
• Really, more evidence for long COVID and impaired cognition (NEJM)
• Memory assessment before and after COVID-19 (NEJM)
• Please complete this memory questionnaire (Community hyperbaric)
• Impact of long-term COVID-19 on workers in healthcare settings (PLoS One)
• Healthcare workers have difficulty assessing long COVID (CIDRAP)
• Contribute to our ASTMH fundraiser at PWB
• Letters read on TWiV 1094
• Dr. Griffin's COVID treatment summary (pdf)
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to [email protected]