In his weekly clinical update Dr. Griffin discusses modelling the adjustment of COVID-19 response and exit from dynamic zero-COVID in China, canine real-time detection of SARS-CoV-2 infections in the context of a mass screening event, two masks can be worse than one: N95 respirator failure caused by an overlying face mask, airflow patterns in double-occupancy patient rooms may contribute to roommate-to-roommate transmission of severe SARS-CoV-2, clinical validation of a novel T-Cell receptor sequencing assay for identification of recent or prior SARS-CoV-2 infection, antibody-dependent cellular cytotoxicity against SARS-CoV-2 Omicron sub-lineages is reduced in convalescent sera, regardless of the infecting variant, VV116 versus Nirmatrelvir–Ritonavir for oral treatment of Covid-19, Nirmatrelvir plus Ritonavir for early COVID-19 in a U.S. health system, Molnupiravir plus usual care versus usual care alone as early treatment for adults with COVID-19 at increased risk of adverse outcomes, higher dose corticosteroids in hospitalized COVID-19 patients with hypoxia but not requiring ventilatory support, FDA approves Roche’s Actemra (tocilizumab) for the treatment of COVID-19 in hospitalized adults, structural brain changes in post-acute COVID-19 patients with persistent olfactory dysfunction, persistent post–COVID-19 smell loss is associated with immune cell infiltration and altered gene expression in olfactory epithelium, epidemiology of long COVID in US adults, persistent symptoms and sequelae after SARS-CoV-2 infection not requiring hospitalization, and outpatient treatment of Covid-19 with metformin, ivermectin, and fluvoxamine and the development of Long Covid over 10-month follow-up.

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• Modeling the adjustment of COVID-19 response and exit in China (Nature)
• Canine real-time detection of SARS-CoV-2 infections in mass screening events (BMJ)
• N95 respirator failure caused by an overlying face mask (ICHE)
• Airflow in patient rooms may contribute to transmission of severe SARS-CoV-2 (CID)
• Clinical validation of a T-Cell receptor for identification of recent or prior SARS-CoV-2 infection (CID)
• Antibody-dependent cellular cytotoxicity against SARS-CoV-2 Omicron sub-lineages (Cell)
• VV116 vs. Nirmatrelvir–Ritonavir for oral treatment of Covid-19 (NEJM)
• Nirmatrelvir plus Ritonavir for early COVID-19 in a U.S. health system (ACP)
• Molnupiravir as early treatment for adults with COVID-19 (The Lancet)
• Higher dose corticosteroids in hospitalized COVID-19 patients with hypoxia but not requiring ventilatory support (medRxiv)
• FDA approves Tocilizumab for the treatment of COVID-19 in hospitalized adults (Roche)
• Structural brain changes in post-acute COVID-19 patients with olfactory dysfunction (Annals)
• Paxlovid patient eligbiliity screening checklist (FDA)
• Persistent post–COVID-19 smell loss association (Science)
• Epidemiology of long COVID in US adults (CID)
• Persistent symptoms & sequelae after SARS-CoV-2 infection not requiring hospitalization (OFID)
• Outpatient treatment of COVID-19 with metformin, ivermectin, and fluvoxamine & the development of long COVID (medRxiv)
• Contribute to our MicrobeTV fundraiser at PWB
• Dr. Griffin’s treatment guide (pdf)
• Letters read on TWiV 970
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to [email protected]

Carl Zimmer visits the Incubator to record a wide-ranging conversation about COVID-19, including origins, vaccines, public health responses, and impact on society.

Host: Vincent Racaniello

Guest: Carl Zimmer

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Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]

TWiV reviews eukaryotic viruses recovered from ancient permafrost, a mistake made by scientists on Omicron origins, and close relatives of MERS-CoV from bats that bind ACE2 for entry into cells.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker

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• Support MicrobeTV with a Spike t-shirt (Vaccinated.us) with promo code MicrobeTV
• Positions with the Mosquito and Vector Control Division in Harris County Public Health (one and two)
• Ancient eukaryotic viruses from permafrost (bioRxiv)
• We made a mistake (Science)
• Bat MERS-like CoV bind ACE2 (Nature)
• Letters read on TWiV 968
• Timestamps by Jolene. Thanks!

Dickson – Alto Saxophone: Paul Desmond/Cannonball Adderley/Charlie Parker/Randal Despommier: Paul Desmond: Signature album: Paul Desmond:The Complete RCA Victor Recordings (1961-1965). Signature song: Take Five (Dave Brubeck Quartet). Cannonball Adderley: Signature album: The Cannonball Adderley Quintet: Mercy, Mercy, Mercy. Signature song: Mercy, Mercy, Mercy. Charlie Parker (Bird): played in many groups: Signature album: Dizzy Gillespie and His Allstars. Signature song: A Night In Tunisia; Randal Despommier: Signature album: A Midsummer Odyssey. Signature song: I Hope It’s Spring For You. Brianne – How a See-Through Frog Hides its Red Blood from Predators (also covered in The Atlantic) Rich – Mindfulness in Plain English by Ven. Henepola Gunaratana Vincent – Unveiling skin macrophage dynamics explains both tattoo persistence and strenuous removal

Rona – WKCR, FM 89.9 Columbia‘s radio station Alan – XKCD Proxy Variable

Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]

In his weekly clinical update Dr. Griffin discusses how immunological dysfunction persists for 8 months following initial mild-to-moderate SARS-CoV-2 infection, prevalence of SARS-CoV-2 and influenza coinfection and clinical characteristics among children and adolescents aged

Vincent travels to the NIH campus to speak with Jeffery Taubenberger about his career, the 1918 influenza pandemic, deciphering the genome sequence of the virus from tissues of disease victims and using it to rescue infectious virus.

Host: Vincent Racaniello

Guest: Jeffery Taubenberger

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• Support MicrobeTV with a Spike t-shirt (Vaccinated.us) with promo code MicrobeTV
• Influenza 1918 pandemic questions answered (Sci Transl Med)
• Reconstructed 1918 influenza virus (Science)
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]

Brazilian infectious diseases physician Esper Kallas returns to TWiV to discuss the state of viral diseases in his country, including those cause by Zika, dengue, and yellow fever viruses, MPOX, and SARS-CoV-2.

Hosts: Vincent Racaniello and Alan Dove

Guest: Esper Kallas

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• Support MicrobeTV with a Spike t-shirt (Vaccinated.us) with promo code MicrobeTV
• International Scientific Coordinator Position (agajewski at icsnicaragua.org for more info)
• Viral kinetics in sylvatic yellow fever (J Inf Dis)
• Safety and efficacy of Butanan-DV (Lancet Inf Dis)
• Immune responses to CoronaVac (Front Immunol)
• Timestamps by Jolene. Thanks!

Alan – A Voyage for Madmen Vincent – Some favorite holiday cookies: pignoli cookies and pfeffernusse

Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]

In his weekly clinical update Dr. Griffin discusses Dr. Griffin discusses progress toward poliomyelitis eradication in Afghanistan, reduced risk for Mpox after receipt of 1 or 2 doses of JYNNEOS vaccine compared with risk among unvaccinated persons, reduced airborne transmission of SARS-CoV-2 BA.1 Omicron virus in Syrian hamsters, authorized updated (Bivalent) COVID-19 vaccines for children down to 6 months of age, low neutralization of SARS-CoV-2 Omicron BA.2.75.2, BQ.1.1, and XBB.1 by parental mRNA vaccine or a BA.5-bivalent booster, efficacy of antiviral agents against omicron subvariants BQ.1.1 and XBB, incidence of viral rebound after treatment with Nirmatrelvir-Ritonavir and Molnupiravir, and the effectiveness of coronavirus disease 2019 (COVID-19) vaccine in the prevention of post–COVID-19 conditions.

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• Progress toward Poliomyelitis eradication in Afghanistan (CDC)
• Reduced risk for Mpox after receipt of 1 or 2 Doses of JYNNEOS vaccine (CDC)
• Reduced airborne transmission of BA.1 Omicron virus in Syrian hamsters (PLOS)
• Authorized bivalent vaccines for children down to 6 months of age (FDA)
• Low neutralization of BA.2.75.2, BQ.1.1, and XBB.1 by parental mRNA vaccine (Nature)
• Efficacy of antiviral agents against Omicron subvariants BQ.1.1 and XBB (NEJM)
• Viral rebound after treatment with Nirmatrelvir-Ritonavir and Molnupiravir (JAMA)
• Paxlovid patient eligbiliity screening checklist (FDA)
• Effectiveness of COVID-19 vaccines in prevention of post–infection conditions (ASHE)
• Contribute to our MicrobeTV fundraiser at PWB
• Dr. Griffin’s treatment guide (pdf)
• Letters read on TWiV 964
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to [email protected]

Vincent travels to Cornell University to speak with Gary Whittaker about regulation by proteolytic processing of the fusion activity of the spike protein of SARS-CoV-2, and feline coronavirus transmission, replication and disease.

Hosts: Vincent Racaniello

Guest: Gary Whittaker

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• SARS-CoV-2 spike and its furin cleavage site (Lancet Microbe)
• TMPRSS2 inhibitor blocks SARS-CoV-2 reproduction (Nature)
• Distinct spike proteins of feline coronaviruses (Viruses)
• Feline coronavirus and feline infectious peritonitis (J Zoo Wild Med)
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]

Paul Offit returns to TWiV to discuss why the bivalent booster dosing story should be a cautionary tale of how not to move forward in this pandemic.

Hosts: Vincent Racaniello and Rich Condit

Guest: Paul Offit

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• Antibody responses to bivalent booster (bioRxiv)
• Immunogenicity of bivalent vaccine (bioRxiv)
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]

Astrophysicist Chiara Mingarelli joins TWiV to discuss her career and her work using pulse timing arrays to study the gravitational wave background, ripples in the fabric of spacetime that are caused by events such as the merging of black holes.

Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Angela Mingarelli

Guest: Chirara Mingarelli

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Become a patron of TWiV!

• Support MicrobeTV with a Spike t-shirt (Vaccinated.us) with promo code MicrobeTV
• International Scientific Coordinator Position (agajewski at icsnicaragua.org for more info)
• Seeing the gravitational wave universe (Science)
• Timestamps by Jolene. Thanks!

Angela – OpenAI Playground and Nature Milestones: T cells Chiara – The Biggest Ideas in the Universe by Sean Carroll Kathy – Recycling PVC and here and here Rich – Brome Bird Care Squirrel Buster Plus  (Bonus pick: 1971 Volvo 142 Commercial – With John Cameron Swayze) Vincent – Journey to the Microcosmos

Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]