In COVID-19 clinical update #105, Daniel Griffin discusses changes in brain structure after infection, dementia in patients with pneumonia, Paxlovid in children, mask effectiveness in schools, host factors and severe disease, post-acute symptoms, and the mission of CEPI.

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• Infection and changes in brain structure (Nature)
• Dementia among pneumonia survivors (Open Forum Inf Dis)
• Narrative dynamics around COVID-19 vaccines (FSI)
• Children and COVID (AAP)
• Paxlovid in pediatric patients (Pfizer)
• Mask effectiveness in schools (MMWR)
• Host factors and severe disease (Nature)
• Antiviral efficacy against BA.2 (NEJM)
• Post-acute symptoms, Denmark (medRxiv)
• Risk of sequelae after infection (BMJ)
• CEPI (TWiV 612)
• Contribute to ASTMH fundraiser at PWB
• Letters read on TWiV 874
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to [email protected]

TWiV reviews the six known coronaviruses that infect pigs and what can be learned about human infections, and how the giant Mimivirus DNA genome is organized into a nucleocapsid.

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Brianne Barker

Click arrow to play Download TWiV 873 (128 MB .mp3, 107 min) Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email

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• ABRCMS ePoster Spring Symposium for Emerging Scientists
• Porcine coronaviruses (Virol Sin)
• Mimivirus nucleocapsid (bioRxiv)
• Letters read on TWiV 873
• Timestamps by Jolene. Thanks!

Brianne – The Dinosaur Age May Have Ended in Springtime Alan – The Track of the Typhoon, and me reading it. Rich – 12 Monkeys Vincent – Anna Mason's Art Channel

Richard – SARS-CoV-2 in animals: Situation report #9 Jason – Counting App and CountThings from Photos

Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]

In COVID-19 clinical update #104, Daniel Griffin reviews effectiveness of mRNA vaccines among children, number of children affected by disease, accuracy of rapid antigen tests, CDC guidance for prevention strategies, monoclonal antibody effectiveness, predicting progression to severe respiratory failure from pneumonia, risk of long COVID after two vaccine doses, and peripheral neuropathy in long COVID.

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• Vaccine effectiveness 5-11 year olds (medRxiv)
• Vaccine effectiveness vs ED and UCE 5-12 year olds (medRxiv)
• Children affected by COVID (Lancet)
• Accuracy of rapid antigen tests (medRxiv)
• COVID community levels (CDC)
• Therapeutics guidelines (WHO)
• Mortality among SOT (Clin Inf Dis)
• Long COVID after two vaccine doses (medRxiv)
• Peripheral neuropathy in COVID patients (Neurology)
• Letters read on TWiV 872
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to [email protected]

TWiV discusses whether or not Omicron should be designated a new serotype of SARS-CoV-2, and the finding that amino acid changes that adapt SARS-CoV-2 to mink or ferret do not increase fitness in the human airway.

Hosts: Vincent Racaniello, Alan Dove, and Rich Condit

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• ABRCMS ePoster Spring Symposium for Emerging Scientists
• ASV Annual Meeting Registration (ASV)
• Microbiology & Immunology at LSU Health
• Is Omicron a new serotype? (Nat Rev Micr)
• Adaptation of SARS-CoV-2 to mink/ferret (Cell Rep)
• Letters read on TWiV 871
• Timestamps by Jolene. Thanks!

Alan – Which Immune Cell Are You? and Michaeleen Doucleff's article Rich – Vaccinated: One Man's Quest to Defeat the World's Deadliest Diseases by Paul A. Offit Vincent – Ebola on Canvas

Les – Ologies podcast

Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]

In COVID-19 clinical update #102, Daniel Griffin covers immunocompromised people, hospitalization of children, vaccine usage update, Omicron and cross-reactive neutralizing antibodies, reinfection prevents disease in hamsters, repeated infections with endemic coronaviruses, global burden of antimicrobial resistance, ivermectin not protective in hamsters, and Omicron evades therapeutic monoclonals.

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• What does society owe immunocompromised people (Atlantic)
• Prevalence of immunosuppression in US (JAME)
• Hospitalizations of children (MMWR)
• Clinical considerations for vaccines (CDC)
• Sanofi seeks vaccine approval (Sanofi)
• Omicron triggers cross-reactive neutralization (medRxiv)
• Reinfection prevents disease in hamsters (Cell)
• Repeated infections with endemic CoV (J Inf Dis)
• Global burden of antimicrobial resistance (Lancet)
• Ivermectin not protective in hamsters (bioRxiv)
• Omicron evades therapeutic monoclonals (bioRxiv)
• Letters read on TWiV 870
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to [email protected]

TWiV reviews epidemiological and experimental evidence that infection with Epstein-Barr virus leads to the production of antibodies against a viral protein that cross-react with a human protein, leading to multiple sclerosis.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Brianne Barker

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• ABRCMS ePoster Spring Symposium for Emerging Scientists
• ASV Annual Meeting Registration (ASV)
• Microbiology & Immunology at LSU Health
• Viremia in human poliomyelitis (J Exp Med)
• EBV associated with MS (Science)
• MS antibodies Bind EBV EBNA1 and GlialCAM (Nature)
• Letters read on TWiV 869
• Timestamps by Jolene. Thanks!

Dickson – Rapid intensification of the emerging southwestern North American megadrought in 2020–2021 Brianne – Which Immune Cell Are You? Rich – Nikola Tesla – 3D Anamorphosis Vincent – Paul's Uncle Doesn't Want to Get Vaccinated

Bob – The 1969 Apollo Guidance Computer Anne – Decoding the Gurus with Dan Wilson Beth – FrenchGuyCooking

Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]

In COVID-19 clinical update #102, Daniel Griffin reviews children and COVID, effectiveness of maternal vaccination, vaccines for immunocompromised, primary care physicians and vaccination rates, booster safety among adults, placentitis, azithromycin, oral Nirmatrelvir, Omicron antibody evasion, EUA for bebtelovimab, IL-1 blocking agents, thromboprophylaxis, effectiveness of vaccines against long COVID, and risks of mental health outcomes.

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• Children and COVID state data (AAP)
• Effectiveness of maternal vaccination (MMWR)
• Vaccines for immunocompromised (CDC)
• PCP and vaccination rates (JAMA)
• Booster safety among adults (MMWR)
• Placental tissue destruction and placentitis (Arch Path Lab Med)
• Azithromycin meta-analysis (J Antimicrob Chemo)
• Oral Nirmatrelvir for high-risk, nonhospitalized adults (NEJM)
• Omicron antibody evasion (bioRxiv)
• EUA for bebtelovimab (FDA)
• IL-1 blocking agents (Cochrane)
• Thromboprophylaxis (Chest)
• Effectiveness of vaccines against long COVID (UK Health)
• COVID complications in Australia (Lancet)
• Risks of mental health outcomes (BMJ)
• Letters read on TWiV 868
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to [email protected]

TWiV reviews an experimental, intranasally administered SARS-CoV-2 vaccine that utilizes adenovirus vectors to deliver three viral proteins and induces immunity to ancestral and variant isolates.

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler

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• Dorothy Horstmann (Wikipedia)
• Intranasal SARS-CoV-2 experimental vaccine (Cell)
• t-SNE (Wikipedia)
• Timestamps by Jolene. Thanks!

Kathy – 477-mile-long megaflash lightning in Seattle Times (originally Washington Post) and extra info from Rich World Meteorological Org Rich – NIAID Global Research (Mali) Alan – New method for recycling electric car batteries Vincent – Q&A with A&V

Addie – Vaccine Podcast Jennie – Dr. Katelyn Jetelina, aka Your Local Epidemiologist

Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]

Amy returns to TWiV to discuss her work on the identification of cross-reactive antibody responses among diverse enteroviruses, and the implications for our understanding of viral pathogenesis and seroprevalence studies.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit Brianne Barker, and Amy Rosenfeld

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• ABRCMS ePoster Spring Symposium for Emerging Scientists
• Cross-reactive enterovirus antibodies (mBio)
• Poliovirus receptor transgenic mice (virology blog)
• Timestamps by Jolene. Thanks!

Dickson – European scientists set new record in production of nuclear fusion energy Amy – Alfredo's Magic Wand Brianne – What Happened After the Chicken-Pox Vaccine? Rich – Year Three of COVID-19: Harsh Truths, Realities, and Glimmers of Hope Vincent – Economists Are Fueling the War Against Public Health

Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]

In COVID-19 clinical update #101, Daniel Griffin discusses children and COVID, human challenge study results, effectiveness of mask use, Omicron boost in macaques, mucosal vaccine candidate, long-term cardiovascular outcomes, and global vaccine perceptions.

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• Children and COVID state data (AAP)
• Human challenge study (Res Sq)
• Effectiveness of mask use (MMWR)
• Omicron boost in macaques (bioRxiv)
• Mucosal vaccine candidate (Cell)
• Long-term cardiovascular outcomes (Nat Med)
• Global vaccine perceptions (PLoSNTD)
• Letters read on TWiV 865
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to [email protected]