Host: Vincent Racaniello

Guest: Sandy Weller

Vincent speaks with Sandy Weller about her career and her work on the mechanisms of synthesis, maturation and cleavage and packaging of viral DNA genomes.

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• Cell killing by avian leukosis virus (Sandy's first paper, J Virol)
• ND10 protein and herpes simplex virus replication (J Virol)
• Recombination promoted by DNA viruses (Ann Rev Micro)
• HSV-1 and DNA damage response (Fut Virol)
• Video of this episode at YouTube

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Send your virology questions and comments to [email protected]

Host: Vincent Racaniello

Guest: David Tuller

Vincent speaks with David Tuller about flaws in the U.K's $8 million PACE trial for chronic fatigue syndrome, and efforts to have the trial data released.

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• Science and journalism (TWiV 111)
• Chronic fatigue syndrome and the CDC (virology blog)
• PACE trial (Lancet)
• Trial by error part one, two, three (virology blog)
• PACE economics analysis (PLoS One)
• All articles by David Tuller at virology blog
• Valerie Eliot Smith's blog
• Karina Hansen, prisioner of Denmark

This episode is sponsored by CuriosityStream. Get two months free when you sign up at curiositystream.com/microbe and use the promo code MICROBE.

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Host: Vincent Racaniello

Guest: Peter Palese

Vincent speaks with Peter Palese about his illustrious career in virology, from early work on neuraminidases to universal influenza virus vaccines.

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• Palese Laboratory
• Pig kidney neuraminidase (Hoppe Seylers Z Physiol Chem)
• DNAse in cytoplasmic DNA virus (Virology)
• Inhibitor of influenza virus neuraminidase (Virology)
• Influenza neuraminidase defective mutants (Virology)
• Swine influenza virus of 1976 RNA pattern (Nature)
• 1977 influenza H1N1 similar to 1950s strains (Nature)
• H5N1 influenza: Facts, not fear (PNAS)
• Influenza HA stalk immunity in ferrets (J Virol)

This episode is sponsored by CuriosityStream. Get two months free when you sign up at curiositystream.com/microbe and use the promo code MICROBE.

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Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler

Guest: Stephen J. Russell

From ASV 2016 at Virginia Tech, Vincent, Rich and Kathy speak with Stephen Russell about his career and his work on oncolytic virotherapy - using viruses to treat cancers.

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• Hokies go viral (TWiV 285)
• MV NIS de Myelo (TWiV 298)
• Remission of disseminated myeloma after MV treatment (Mayo Clin Proc)
• miRNA detargeting (J Virol)
• Video of this episode at YouTube

This episode is sponsored by CuriosityStream. Get two months free when you sign up at curiositystream.com/microbe and use the promo code MICROBE.

Kathy - Can you explain your science in 30 seconds? and How Far Can We Go?Rich - Small asteroid Earth's companionVincent - The Gene by Siddhartha Mukherjee

Dylan - Microsculpture by Levon Biss (website)

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Hosts: Vincent Racaniello and Alan Dove

Guest: Erica Ollmann Saphire

Vincent and Alan speak with Erica about her career and her work on understanding the functions of proteins of Ebolaviruses, Marburg virus, and other hemorrhagic fever viruses, at ASM Microbe 2016 in Boston, MA.

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• Structure of antibodies bound to Ebola virus glycoprotein (PNAS)
• Structure of cross-reactive filovirus antibody (Cell)
• Multiple functions of Ebola virus VP40 protein (Cell)
• View video of this episode on YouTube
• Letters read on TWiV 394

This episode is sponsored by CuriosityStream. Get two months free when you sign up at curiositystream.com/microbe and use the promo code MICROBE.

Alan - Slime LapseVincent - Virus Watch

Patricia - NECSS, People Behind the Science, The Life Scientific Peter - Iron Lung on eBay

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Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler

The TWiVerati revisit possible sexual transmission of Zika virus, and reveal how a cell protein that allows hepatitis C virus replication in cell culture enhances vitamin E mediated protection against lipid peroxidation.

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• Late sexual transmission of Zika virus (Lancet)
• Zika virus disease in US (CDC)
• Zika virus lab accident (ABC News)
• Mosquito eradication (virology blog)
• Florida mosquito control (TWiV 111)
• How tequila mosquito (TWiV 178)
• SEC14L2 allows HCV replication in cell culture (Nature)
• Lipid peroxidation (Wikipedia)
• HCV replicase regulated by lipid peroxidation (Nat Med)
• Letters read on TWiV 393

This episode is sponsored by CuriosityStream. Get two months free when you sign up at curiositystream.com/microbe and use the promo code MICROBE.

Also brought to you by ASV 2016

Alan - All About That SpaceRich - The Expanse by James S.A. Corey (SyFy) Kathy - Five Pivotal Paragraphs in a PaperVincent - Agar Art Contest Winners

Ted - Marshall Niremberg charts

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Host: Vincent Racaniello

Guests: Michael Diamond, Michaela Gack, Laura Kramer, and Charles Rice

Four virologists discuss our current understanding of Zika virus biology, pathogenesis, transmission, and prevention, in this special live episode recorded at the American Society for Microbiology in Washington, DC.

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This episode is sponsored by CuriosityStream. Get two months free when you sign up at curiositystream.com/microbe and use the promo code MICROBE.

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Hosts: Vincent Racaniello, Alan Dove, and Rich Condit

Guests: David Pride and Forest Rohwer

If you have always wanted to know what coral reefs and the human oral cavity have in common, listen as guests David Pride and Forest Rohwer talk about their work on the microbiomes and viromes of these two environments, and you'll also understand why mucus is cool.

• Lytic to temperate switching of viral communities (Nature)
• Viromes in ancestral holobiont Hydra (PLoS One)
• Phage in human oral cavity (J Oral Micro)
• Human oral viruses are personal, consistent, gender specific (ISME)
• Video of this episode at YouTube

This episode is sponsored by CuriosityStream. Get two months free when you sign up at curiositystream.com/microbe and use the promo code MICROBE.

Alan - Vax Pack HeroRich - Helicopter autorotation Vincent - Live in Our Phage World by Forest Rohwer, Merry Youle, Heather Maughan, Nao Hisakawa

Matt - Experiment.com

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Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler

Guests: Ethan Jackson and Jonathan Carlson

Project Premonition, a Microsoft Research project that uses drones to capture mosquitoes and analyze them for pathogens, preprint servers, and three mouse models for Zika virus induced birth defects are the topics of this episode hosted by the TWiumvirate and theirs guests Ethan and Jonathan.

• Project Premonition
• Premonition feasibility study in Grenada
• Zika virus causes microcephaly in mice (Cell Stem Cell)
• Brazilian Zika virus causes defects in experimental models (Nature)
• Zika virus causes placental damage and fetal demise in mice (Cell)
• Letters read on TWiV 390

This episode is sponsored by CuriosityStream. Get two months free when you sign up at curiositystream.com/microbe and use the promo code MICROBE.

Also brought to you by ASV 2016

Dickson - Germany nearly reached 100% renewable power Alan - Vertical City documentary and Lumino City gameRich - Errol Morris: 'Demon in the Freezer' Kathy - Entropic Time YouTube by A Capella Science (watch "the making of")Vincent - Agar Art contest finalists

Jennie - SciFi reading (scroll down)

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Host: Vincent Racaniello

Guest: Stan Lemon

Vincent speaks with Stan Lemon about his career in virology, from early work on Epstein Barr virus, through making essential discoveries about hepatitis A virus, hepatitis C virus, and rhinoviruses.

• Live in Edmonton, Eh? (TWiV 235)
• Replication of EBV in epithelial cells (Nature)
• Returning to Carolina after 14 years
• Evolutionary origins of hepatitis A virus (TWiV 265)
• cre in rhinovirus genome (RNA)
• Naked viruses that aren't always naked (Ann Rev Virol)
• miR-122 and hepatitis C virus RNA (Cell Host Micr)

This episode is sponsored by CuriosityStream. Get two months free when you sign up at curiositystream.com/microbe and use the promo code MICROBE.

Send your virology questions and comments to [email protected]