This Week in Virology

TWiV 1275: An amazing sequence and a gutsy therapy


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TWiV explains the Nobel Prize-winning discovery of pre-mRNA splicing, and engineering bacteriophage to deliver proteins to the human intestine.

Hosts: Vincent Racaniello, Kathy Spindler, and Brianne Barker

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Links for this episode
  • Support science education at MicrobeTV
  • Immune 100 live at the Incubator
  • Spliced segments of adenovirus mRNA (PNAS)
  • An amazing sequence in adenovirus mRNA (Cell)
  • Nobel Prize for mRNA splicing (Nobel)
  • A predominant undecanucleotide in adenovirus late mRNAs (Cell)
  • Splicing RNA with Phillip A. Sharp (ASM)
  • Protein production in the gut by engineered phage (Nat Biotech)
  • Engineered phage T4 (Curr Op Virol)
  • Timestamps by Jolene Ramsey. Thanks!
Weekly Picks

Brianne – Can You Identify These Lines from Classic SciFi Novels? Kathy – Saturday Morning Physics, Photograph 51 and JCE article Rich – Wikipedia:Wiki Science Competition 2025 in the United States Jolene – Data visualization workshop Vincent – Transformer: The Deep Chemistry of Life and Death by Nick Lane

Intro music is by Ronald Jenkees

Send your virology questions and comments to [email protected]

Content in this podcast should not be construed as medical advice.

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