Ben tenOever joins the TWiVoli to discuss the evolution of RNA interference and his lab's finding that RNAse III nucleases, needed for the maturation of cellular RNAs, are an ancient antiviral RNA recognition platform in all domains of life.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler

Guest: Ben tenOever

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Links for this episode

• RNAseIII is an ancient antiviral effector (Nature)
• Influenza suppression of RNAi (PNAS)
• Questioning mammalian antiviral RNAi (Nat Micro)
• Antiviral protection via RdRp (PLoS Path)
• Evolution of antiviral defense (Cell Host Micr)
• Letters read on TWiV 450

Weekly Science Picks

Ben - Invisible Invaders by Peter Radetsky Kathy - ASV 2017 Virolympics Crossword solved (pdf) and National Museum of the Air Force Rich - Columbia river gorge and Undaunted Courage by Stephen Ambrose Dickson - All the World's Earthquakes Alan - Map of Roman roads Vincent - Brain atlas of fly behavior

Listener Pick

Rob - Vaccinate Your Kids and Charles Darwin Natural Selection Islam - Self-assembling virus and Virus Patterns

Intro music is by Ronald Jenkees.

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