Brianne joins the TWiVMasters to explain how mutations in genes encoding RNA polymerase III predispose children to severe varicella, and detection of an RNA virus by a DNA sensor.

Hosts: Vincent Racaniello and Rich Condit

Guest: Brianne Barker

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Links for this episode

• RNA pol III mutations underlie severe varicella (J Clin Inves)
• Dengue virus activates cGAS by release of mitochondrial DNA (Sci Rep)
• Dengue virus NS2B protein targets cGAS for degradation (Nat Micr)
• Image credit
• Letters read on TWiV 456

This episode is brought to you by the Defense Threat Reduction Agency. Part of the U.S. Department of Defense, the Agency's Chemical and Biological Technologies Department hosts the 2017 Chemical and Biological Defense Science & Technology Conference to exchange information on the latest and most dynamic developments for countering chemical and biological weapons of mass destruction. Find out more at http://www.cbdstconference.com

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Intro music is by Ronald Jenkees.

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