Lonya and Jeremy take the TWiV team beTWIXt primate immunodeficiency virus proteins Vpx and Vpr and how they counteract transcriptional repression of proviruses by the HUSH complex.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Kathy Spindler, and Brianne Barker

Guests: Leonid Yorkovetskiy and Jeremy Luban

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Links for this episode

• Pan American Society for Clinical Virology San Diego and Houston Regional Meetings
• Vpr and Vpx counter HUSH (Nat Micro)
• Vpr and Vpx counter HUSH (bioRxiv version)
• Schematic of HUSH complex (Lehner lab)
• Olive colobus monkey sound credit
• Image credit: William (Ted) Diehl
• Letters read on TWiV 516
• Timestamps by Jolene. Thanks!

Weekly Science Picks

Brianne - The Chimp and the River by David Quammen Rich- James Cook's First Voyage Journal (20 sec Google Earth summary) Kathy- High resolution Antarctica map NYTimes 46MB Maps (more info and 43 tb maps) Dickson- Jellyfish Jeremy - Pictorial Guide to Living Primates; All The World's PrimatesLonya- Chougui et al. HIV-2/SIV Vpx counters HUSH Vincent - Research!America

Intro music is by Ronald Jenkees.

Send your virology questions and comments to [email protected]