TWiV explains why hydroxychloroquine failed in humans despite showing antiviral effects in cells, and reviews the published data on the Pfizer/BioNTech mRNA vaccine.

Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker

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Links for this episode

• TMPRSS2 is why hydroxychloroquine failed (PLoS Path)
• Safety and efficacy of BNT162b2 mRNA vaccine (NEJM)
• Letters read on TWiV 715
• Timestamps by Jolene. Thanks!

Weekly Picks

Brianne – How the Body Reacts to Viruses Rich – How do wombats poop cubes? Kathy – The Verse by the Side of the Road Vincent – Janet Iwasa’s SARS-CoV-2 entry animation

Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]