In COVID-19 clinical update #48, Daniel Griffin reviews effect of spike amino acid changes on neutralization with monoclonal antibodies, Sputnik V safety and efficacy results, increased reactogenicity after a single vaccine dose in seropositive individuals, single dose vaccination in seropositive health care workers, and results of three clinical trials on the use of anticoagulants.

Hosts: Daniel Griffin and Vincent Racaniello

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Links for this episode

• Resistance of variants to mAb neutralization (bioRxiv)
• Safety and efficacy of Sputnik V (Lancet)
• Increased vaccine reactogenicity in seropositives (medRxiv)
• Single dose vaccination in seropositive health care workers (medRxiv)
• Update on vaccine intervals (CDC)
• Single dose AZD1222 results (Lancet preprints)
• Three RCT on anticoagulants (NIH)
• Letters read on TWiV 716
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to [email protected]