For the final episode of 2021, TWiV reviews an experimental infectious attenuated Lassa fever vaccine based on a codon-deoptimized glycoprotein gene, and SARS-CoV-2 infection of free-ranging white-tailed deer.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Kathy Spindler, and Brianne Barker

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Links for this episode

• Codon-deoptimized Lassa fever vaccine (mBio)
• Attenuation of dengue virus by codon deoptimization (TWiV 351)
• Codon deoptimization of poliovirus and RS virus (TWiV 740)
• Codon deoptimization of DNA viruses (TWiV 362 letters)
• CEPI on TWiV 612
• SARS-CoV-2 in white-tailed deer (Nature)
• Letters read on TWiV 847
• Timestamps by Jolene. Thanks!

Weekly Picks

Dickson – EO Wilson (Ants and The Conversation) Brianne – The Best Fun Science Stories of 2021 Kathy – Using sound for data analysis; chemotactic bacteria and Moo loo story Alan – Owls of the Easern Ice, by Jonathan Slaght Vincent – TWiV 9: Fever! The discovery of Lassa virus and TWiV 548: Mice, shrews, and caterpillars

Listener Picks

Larry – Immunity Jeff – Daily Hospital Surveillance Report

Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]