TWiV explains why this season's influenza vaccine is not protecting against mild to moderate disease caused by H3N2 virus, and that antibody-dependent entry of SARS-CoV-2 into monocytes is a major contributor to severe COVID-19.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Amy Rosenfeld

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Links for this episode

• Seasonal influenza vaccine effectiveness (MMWR)
• Properties of a dominant H3N2 variant (bioRxiv)
• Scott Henley on influenza vaccine growth in eggs (TWiV 480)
• Fc receptor dependent entry of SARS-CoV-2 into monocytes (Nature)
• Timestamps by Jolene. Thanks!

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Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]