TWiV reviews the genetic characterization of a new strain of type 2 oral polio vaccine and its implications for eradication, and how a polymorphism in humans comprising a single amino acid change in an antibody molecule regulates vaccine elicitation of broadly neutralizing antibodies against influenza virus HA.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Kathy Spindler, and Brianne Barker

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Links for this episode

• Characterization of novel OPV2 from humans (MMWR)
• Engineering nOPV2 (TWiV 756)
• Genome sequence of Rockland County NY OPV2 isolate (Genbank)
• Allelic polymorphism and vaccine induction of influenza virus bnAbs (Immunity)
• Letters read on TWiV 931
• Timestamps by Jolene. Thanks!

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Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]