Charles Brenner is a leading Global expert in the biology, chemistry and Medicine of NAD the central Catalyst of metabolism he currently works at City of Hope in Los Angeles as professor and chair of the Department of diabetes and cancer metabolism.

I'm intrigued by Charles' recent rebuttal to David Sinclair's thesis regarding longevity. "Surtuins are not conserved longevity genes" published in the Journal of Life metabolism in October 2022.

In this episode Charles and I discuss this paper and his view on the science of longevity. We will expand on this while also discussing various other topics related to NAD, use cases for NR, metabolism and where influencers go wrong in the nutrition space.

If you have any additional questions you would like answered in the future, let me know in the comments.

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Chapters:

00:00:00 - The Role of NAD in Metabolism and Living Things

00:11:18 - NAD and the De Novo Pathway

00:21:50 - The Composition of NAD and NR

00:33:07 - The Innate Immune Response and NAD Churning

00:44:08 - The Longevity of Naked Mole Rats and Humans

00:55:27 - The Myth of Sirtuin Genes and Longevity

01:06:26 - Reproducibility Issues and False Claims

01:17:32 - Targeting the Aging System

01:27:44 - The Uselessness of Age Tests

01:38:26 - Q&A on Twitter

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Connect with Dr Charles Brenner:

- Twitter: https://twitter.com/CharlesMBrenner

- Website: https://www.brennerlab.net/

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Connect with Dr Charles Brenner:

- Twitter: https://twitter.com/CharlesMBrenner

- Website: https://www.brennerlab.net/

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