Christopher Kirchhoff helped launch a Defense Department office that aimed to bring Silicon Valley technology to the US military.  Christopher’s problem is this: How can the giant bureaucracy that is the US military keep up with technological change?

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Jared Baeten is senior vice president in virology at Gilead Sciences. Jared's problem is this: In a world without a vaccine, how do you make a medicine that people will actually take to help prevent HIV?

There’s already a daily pill that reduces the risk of getting HIV, but a majority of people who are at high risk are unwilling or unable to take it.

So Jared and his colleagues are developing a new drug, lenacapivir, designed to be given as a shot once every six months.

Note: The views and opinions expressed in this episode are those of the guest and do not necessarily reflect the views or positions of any entities they represent.

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Carlos Araque is the co-founder and CEO of Quaise Energy. Carlos' problem is this: How do you make drilling for geothermal energy as routine, widespread, and profitable as drilling for oil or gas? The answer involves digging deeper into the Earth than anyone has ever dug before.

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Ben Rapoport is the co-founder and CSO of Precision Neuroscience. Ben's problem is this: Can you build a device that allows a paralyzed person to use a computer with only their thoughts – without damaging their brain?

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Jeff Cardenas is the co-founder and CEO of Apptronik. Jeff's problem is this: Can you make a safe, reliable humanoid robot – for less than $50,000?

In the short term, Apptronik’s robots will work in factories. But Jeff’s long-term goal – based on the experience of his own grandparents – is to build robots that can help care for the elderly.

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We need better, cheaper ways to store solar and wind energy when it’s dark out and the wind isn’t blowing.

One option: Compressing air in underground caverns when energy is abundant, then blowing it back out to create energy when you need it. It’s an old idea, but it has some fundamental problems.

Curtis VanWalleghem, the co-founder and CEO of Hydrostor, thinks his company has solved those problems with a new approach. If he’s right, his firm will help fix the biggest bottleneck slowing down the adoption of solar and wind power.

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There are moments in history when people make huge technological advances all of a sudden. Think of the Manhattan Project, the Apollo missions, or, more recently, generative AI. But what do these moments have in common? Is there some set of conditions that lead to massive technological leaps?

Byrne Hobart is the author of a finance newsletter called The Diff, and the co-author of Boom: Bubbles and the End of Stagnation. In the book, Bryne makes the case for one thing that is really helpful if you want to make a wild technological leap: a bubble.

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AI works well in the virtual world. That’s partly because the internet provides so much data to train AI models. But there’s no analogous data set for the physical world – and as a result, AI doesn’t work as well there… yet.

 Edward Mehr is the co-founder and CEO of Machina Labs. Edward's problem is this: How can you use AI to turn robots from dumb, inflexible machines into skilled, versatile craftsmen?

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In the past few years,  NVIDIA has become one of the most valuable and important companies in the world by making GPUs, the chips powering the AI boom. But where did the company come from, and why are NVIDIA chips the ones that dominate AI?

Tae Kim is the author of a new book called The Nvidia Way. In his book, he tells the story of how NVIDIA’s founder and CEO, Jensen Huang, set NVIDIA on the path to becoming what it is today.

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 Claude Shannon is a major figure in the history of technology. Known as the father of information theory, Shannon spent decades at Bell Labs and MIT. But what exactly did Claude Shannon figure out, and why is it so important?

To answer that question, Jacob talked with David Tse, a professor of electrical engineering at Stanford who studied under one of Shannon’s students, and who teaches Shannon to his own students today. David used Shannon's work to make a breakthrough in wireless communication that underpins every phone call we make today.

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