Send us Fan Mail

Some women aren't losing weight on max-dose GLP-1s — and the fix is dosing down, not pushing harder.

Ana Reisdorf, registered dietitian and GLP-1 user, sits down with Alex Mufson, LCSW and founder of Canary House, to unpack why high-functioning women show up as non-responders on Ozempic, Wegovy, and Zepbound. They cover the labs traditional medicine misses, why under-eating sabotages results, and how regulating the body — not suppressing appetite — is what actually moves the scale.

IN THIS EPISODE
- Why some non-responders lose more on a microdose of tirzepatide than on a maximum dose
- The ferritin, fasting insulin, and Dutch Plus markers most GLP-1 prescribers don't run
- The glucose-insulin mismatch behind weight gain that "doesn't make sense"
- Why appetite suppression isn't the goal of GLP-1 therapy — and can stall fat loss entirely
- How epigenetics, survival mode, and high-functioning caretaker patterns block GLP-1 response

ABOUT THE GUEST
Alex Mufson, a Licensed Clinical Social Worker, is the founder of Canary House, an integrative healing practice specializing in high-functioning individuals living with persistent exhaustion, pain, and unexplained symptoms despite normal or inconclusive labs. Her work focuses on nervous, immune, and metabolic regulation for people whose lives appear stable on paper but feel increasingly effortful from the inside.

CONNECT WITH ALEX
Website: https://www.canaryhousehealing.com/
Substack: https://alexmufson.substack.com/
LinkedIn: https://www.linkedin.com/in/alex-mufson-lcsw-96146b29/
Instagram: @alex.mufson, @canaryhousehealing

 
SPONSOR
Folly — Hair support gummies for GLP-1 users. A 300-person study showed less shedding and fuller hair after 4 weeks.
FollyNutrition.com — code GLP1HUB for 20% off

📬 Get The Steady State, Ana's weekly newsletter with GLP-1 guidance from a dietitian who's on one: http://join.glp-1hub.com

🎙 Subscribe wherever you listen to podcasts, and if this episode helped, leave a quick review on Apple Podcasts or Spotify - it's the single best way to help more people find the show.

🌐 Shop GLP-1 essentials, meal plans, and recipes: https://shop.glp-1hub.com
📷 Follow on Instagram: @glp1hub
📺 Watch on YouTube: https://www.youtube.com/@GLP-1hub

*Some of the links shared are affiliate links. When you make a purchase, I will receive a small commission at no cost to you. Thank you for supporting the show.

*The content of this show is for informational purposes only and does not constitute medical advice. The goal of this show is to provide various points of view about GLP-1 Medications. The personal and professional opinion of the guests and their content does not necessarily reflect the opinion of Ana Reisdorf or GLP-1 Hub.