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Tappey Squires is an avid cyclist from North Carolina who lost 150 pounds on Zepbound (tirzepatide) — and got his life back on two wheels.
In this episode, Tappey shares his honest before-and-after story: the weight that made cycling painful, the anxiety he felt before his first injection, the emotional meltdowns through dose increases, and how he ultimately transformed not just his body, but his confidence and quality of life.
He goes deep on the science behind GLP-1 medications — the vagus nerve, gut health, blood sugar — and makes a compelling case for why he believes tirzepatide is one of the most important medications of our time, with potential applications far beyond weight loss, including addiction treatment and heart disease prevention.
In this episode:
- Life before Zepbound — weight, joint pain, and the limits it put on his cycling
- Navigating anxiety around starting GLP-1 medication and confronting fear of side effects
- Why he chose brand-name Zepbound over compounded tirzepatide
- Real talk about dose increases — including a full emotional meltdown
- His 150-lb Zepbound before-and-after transformation
- How losing weight changed his cycling performance, pain levels, and confidence
- Why he believes GLP-1s could revolutionize addiction treatment and heart disease
- Breaking the stigma: "Who gives a sh*t what anyone thinks?"
- Resources: Zepbound Reddit, Lilly coupons, and working with your doctor
By Real Stories. Real Advocacy. Real Impact.4.6
1717 ratings
Tappey Squires is an avid cyclist from North Carolina who lost 150 pounds on Zepbound (tirzepatide) — and got his life back on two wheels.
In this episode, Tappey shares his honest before-and-after story: the weight that made cycling painful, the anxiety he felt before his first injection, the emotional meltdowns through dose increases, and how he ultimately transformed not just his body, but his confidence and quality of life.
He goes deep on the science behind GLP-1 medications — the vagus nerve, gut health, blood sugar — and makes a compelling case for why he believes tirzepatide is one of the most important medications of our time, with potential applications far beyond weight loss, including addiction treatment and heart disease prevention.
In this episode:
- Life before Zepbound — weight, joint pain, and the limits it put on his cycling
- Navigating anxiety around starting GLP-1 medication and confronting fear of side effects
- Why he chose brand-name Zepbound over compounded tirzepatide
- Real talk about dose increases — including a full emotional meltdown
- His 150-lb Zepbound before-and-after transformation
- How losing weight changed his cycling performance, pain levels, and confidence
- Why he believes GLP-1s could revolutionize addiction treatment and heart disease
- Breaking the stigma: "Who gives a sh*t what anyone thinks?"
- Resources: Zepbound Reddit, Lilly coupons, and working with your doctor

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