April 16, 2020

#037 - James Clement: The Switch, Super Centenarians, Autophagy, Antioxidants, Fasting Vs. Feeding, AMPK vs. MTOR, Hacking Aging, And More!

2 hours 6 minutes

GET TRANSCRIPT AND FULL SHOWNOTES: MelanieAvalon.com/TheSwitch

2:00 - Instagram Giveaway: Follow @MelanieAvalon And Comment Your Favorite Biohack To Enter To Win A Signed Copy Of The Switch!

2:25 - IF Biohackers: Intermittent Fasting + Real Foods + Life (Melanie Avalon)

3:40 - FOOD SENSE GUIDE: Get Melanie's App To Tackle Your Food Sensitivities! Food Sense Includes A Searchable Catalogue Of 300+ Foods, Revealing Their Gluten, FODMAP, Lectin, Histamine, Amine, Glutamate, Oxalate, Salicylate, Sulfite, And Thiol Status. Food Sense Also Includes Compound Overviews, Reactions To Look For, Lists Of Foods High And Low In Them, The Ability To Create Your Own Personal Lists, And More!

5:30 - James Unconventional History And Health Revolutions

9:40 - The Studies In Super Centenarians

14:15 - Genetic Mutations, Lifestyle Practices, And Environment For Longevity

21:30 - The Role Of Diet In Longevity

23:15 - The Changeability Of The Gut Microbiome

29:30 - What Is Autophagy And MTOR Why Is It Important For Longevity?

34:45 - Does Autophagy Require Lifestyle Intervention?

37:40 - The Different Routes To Autophagy, And Long Lived Populations Long Lived (Okinawa, Loma Linda, Mount Athos Monks)

42:00 - Modern Diets Like Carnivore, Elimination Diets, And The Role Of Protein In Longevity

46:30 - The Problem With HCHF

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49:30 - The Switch: MTOR, AMPK, And Autophagy

51:40 - Fasting And Calorie Restriction: Overlapping Or Additive?

55:00 - The Different Types of Autophagy

53:20 - Are The Benefits Of IF Just Due To Calorie Restriction Or Weight Loss?

56:20 - The Fasting Mimicking Diet 4:20

58:15 - Combating CR Effects With Exercise

1:01:20 - Fasting Forever And The Need For Cycling

1:03:00 - Daily Vs. Monthly Cycling And Genetic Expression

1:08:15 - Habitual Hunger, Energy Cues , And Retraining Cells With Keto Or Extended Fasts

1:11:30 -Carbs, Comfort Foods, Dopamine and Serotonin From The Gut

1:13:30 - AMPK Activators

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1:21:15 - Gluconeogenesis, Cortisol, Stress, And Blood Sugar

1:27:30 - Elevated Blood Sugar Levels On Low Carb, Elevated Blood Sugar, Aging , And Disease

1:30:20 - Endogenous Vs Exogenous Antioxidants, DNA Breaks, NAD, And The Dark Side To Antioxidants

1:38:25 - Antioxidants While Fasting

1:43:22 - NR and NMN Supplementation

1:50:05 - BEAUTY COUNTER: Non-Toxic Beauty Products Tested For Heavy Metals, Which Support Skin Health And Look Amazing! Shop At Beautycounter.Com/MelanieAvalon For Something Magical! For Exclusive Offers And Discounts, And More On The Science Of Skincare, Get On Melanie's Private Beauty Counter Email List At MelanieAvalon.Com/CleanBeauty!

1:51:45 - The Hermetic Potential Of Low Dose Toxic Exposure

1:58:30 - Are We Programmed to Start Aging At 25?

2:06:30 - Instagram Giveaway: Follow @MelanieAvalon And Comment Your Favorite Biohack To Enter To Win A Signed Copy Of The Switch!

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