March 01, 2024

105. SS-31 Peptide and Other Supplements in the Context of Mitochondrial Dysfunction, The Mitophagy Stack More Powerful Than Urolithin A Alone, How Mitochondrial Dysfunction Creates Chronic Fatigue

27 minutes

In this episode, we explore the research behind SS-31 peptide and other supplements as possible groundbreaking interventions for mitochondrial dysfunction, shedding light on their mechanisms as detailed in the scientific literature. We delve into the concept of the mitophagy stack, presenting it as a superior alternative to "Urolithin a" alone, for enhancing the clearance of damaged mitochondria and rejuvenating cellular energy production. Furthermore, we unravel the complex relationship between mitochondrial dysfunction and chronic fatigue, elucidating how impaired energy production at the cellular level can lead to pervasive fatigue and compromised quality of life.

Topics:

Introduction to Mitochondrial Dysfunction

Chronic illnesses and their relation to mitochondrial dysfunction

Examples: Chronic Fatigue, Chronic Inflammatory Response Syndrome, Lyme Disease, Candida Overgrowth...

Importance of understanding mitochondrial dysfunction on a large scale and biochemical level

Understanding Mitochondrial Dysfunction

Definition and general overview

Underlying causes: Genetic mutations, environmental stressors, toxins, aging

Biochemical pathways involved: Oxidative phosphorylation, reactive oxygen species (ROS) generation, calcium homeostasis, apoptosis

Oxidative Phosphorylation and Dysfunction

Role in ATP production

Components: Electron Transport Chain (ETC) and ATP Synthase

Dysfunctional aspects due to genetic mutations and aging

Vicious cycle of mitochondrial DNA mutations, decreased ATP production, and increased ROS

Factors Contributing to Mitochondrial Dysfunction

Genetic mutations (mtDNA and nDNA)

Aging and its impact on mtDNA

Environmental toxins and stressors (e.g., psychological stress, radiation, biotoxins, toxicants, nutrient deficiency)

Nuclear DNA alterations

Mitophagy and Mitochondrial Biogenesis

Importance of removing old and damaged mitochondria

Role of urolithin a and its enhancement with EGCG in mitophagy

Supporting biogenesis: PQQ, resveratrol, EGCG, anthocyanins, curcumin, glycyrrhizic acid, salidroside

Supplements and Nutrients for Supporting Mitochondrial Function

Clinical trials and effective supplements: L-carnitine, α-lipoic acid, CoQ10, NAD precursors, membrane phospholipids

Peptide Therapy for Mitochondrial Dysfunction

Introduction to SS-31 peptide

Mechanism: Binding to cardiolipin for efficient oxidative phosphorylation

Potential for stimulating mitochondrial biogenesis

Conclusion and Reminder

Only ever work with a medical professional.

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By Chloe Porter

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