The Synthesis of Wellness®

109. Methylene Blue - Oxygen Delivery & Utilization, Mitochondrial Hacking, Antimicrobial Benefits, & The Effect on The Gut Microbiome (+ My Thoughts on Supplementation)


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We uncover the various capabilities of methylene blue, particularly its pivotal roles in enhancing mitochondrial function, optimizing energy production, and facilitating oxygen delivery. We also dive into the question of whether its antimicrobial properties impact the gut microbiome in a positive or negative way. Lastly, we explore the downstream effects of improved mitochondrial function, including cognitive and mood enhancement and potential anti-aging benefits.

Topics:

  1. What is Methylene Blue?

    • Synthetic dye with applications in medicine, biology, and chemistry
    • Antimicrobial properties and electron transfer capabilities
    • The Electron Accepting and Donating Aspect

      • Importance in mitochondrial function and energy production
      • Comparison with NAD+ and NADH
      • Application and Use in Methemoglobinemia

        • Definition and implications of methemoglobinemia
        • Environmental toxins increasing methemoglobin levels
        • Role of methylene blue in reducing methemoglobin
        • Highlighting Methylene Blue's Mechanism

          • Electron transfer to methemoglobin
          • Restoring oxygen-carrying capacity by restoring hemoglobin
          • Metabolism and excretion of methylene blue
          • Methylene Blue in Mitochondrial Energy Production

            • Function in the electron transport chain (ETC)
            • Bypassing disruptions (due to damage/disease) in the ETC
            • Enhancing ATP synthesis
            • Broader Applications and Antimicrobial Properties

              • Photodynamic therapy and photoactivated disinfection
              • Efficacy against a wide range of microorganisms
              • What does it do to the gut microbiome, though?
              • Supplementation routes, dose used in studies, bioavailability
              • Cognitive and Anti-aging Effects

                • Impact on cognitive function and memory
                • Potential anti-aging benefits
                • Studies on neuroprotection and mood enhancement
                • Thank you to our episode sponsors:

                  Dr. Morse's Daily Detox Kit

                  Veri CGM (use code: VSM-THESYNTHESISOFWELLNESS)


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