April 05, 2024

111. 6 Peptides to Support The Gut & Aid in Digestion (Peptides Episode) - AT-1001, KPV, BPC-157, and More (+ a Deep Dive into What Each One Specifically Targets)

30 minutes

In this episode, we set the stage by going through the intricate anatomy of the gut lining, providing a comprehensive understanding of its layers and cellular components. We, then, explore how six gut-supporting peptides and compounds offer promising therapeutic avenues. From larazotide acetate's tight-junction regulation to KPV's anti-inflammatory properties and BPC-157's reparative effects, we dive into the diverse mechanisms by which these peptides contribute to gut health.

Topics:

1. Anatomy of the Gut Lining

- Layers of Mucus

- Varying thickness in different parts of the intestine

- Composition: water, mucins, glycoproteins

- Intestinal Epithelium

- Tight junctions

- Renewal every 3 to 5 days

- Villi and Crypts

- Increase in surface area

- Stem cells in crypts for cellular renewal

- Microvilli

- Amplification of absorptive surface area

2. Lamina Propria

- Contains blood vessels and lymphatic vessels

- Rich in immune cells:

- Lymphocytes (T cells, B cells)

- Macrophages

- Dendritic cells

- Mast cells

- Eosinophils

3. Types of Epithelial Cells

- Enterocytes

- Goblet cells

- Paneth cells

- M cells

- Enteroendocrine cells

- Stem cells

4. Tight Junctions

- Composition: claudins, occludin, junctional adhesion molecules

- Interaction with cytoskeleton (ZO proteins)

- Dynamic regulation

- Role in permeability

5. Disruption of Tight Junctions

- Zonulin release

- Mechanism of increased permeability

6. Gut-Supporting Peptides and Compounds

- Larazotide acetate (AT-1001)

- Tight-junction regulator (think "leaky gut")

- Zonulin receptor antagonist

- KPV

- Sequence of amino acids from alpha-MSH

- Anti-inflammatory

- BPC-157 (Body Protection Compound)

- Derived from human gastric juice

- Protective and reparative effects

7. Additional Gut-Supporting Peptides

- Suprefort Pancreas peptides

- Svetinorm Liver peptides

- Stamakort Stomach peptides

Thanks for tuning in!

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By Chloe Porter

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