April 26, 2024

116. So You've Got Lyme/Mold, Now What? Herxheimer reactions, Why the Body is Chronically Inflamed, & Key Initial Strategies (Herbs, Binders, Tactics)

29 minutes

Today I am addressing the "early steps" in combatting Lyme or mold. So, I begin by diving into the phenomenon of Herxheimer reactions, elucidating its occurrence following antimicrobial therapy initiation for Lyme disease. Through this, I explore the intricate interplay between microbial factors, such as the release of endotoxins (LPS), and host immune responses, leading to a cascade of inflammatory reactions. Moreover, I provide practical strategies that may help mitigate Herxheimer reactions, including gradual dose titration, anti-inflammatory supplementation, binders, baths, and support for the body's natural detoxification pathways (liver, lymph, kidneys, and more).

Topics:

1. Understanding Herx Reactions

- Definition and Manifestation

- General Overview of Symptoms

2. Underlying Mechanisms of Herx Reactions

- Host Immune Responses

- Microbial Factors

3. Microbial Factors in Herx Reactions

- Release of Endotoxins

- Role of Gram-Negative Bacteria

- Impact on Immune Response (LPS)

- Example: Lyme Disease as a Model

4. Inflammatory Response

- Pro-inflammatory Cytokines

- TNF-α, IL-6, IL-1β

- Immune Response Propagation

- Vasodilation

- Vascular Permeability

- Immune Cell Recruitment

5. Acute-Phase Response

- Ex: Induction of Fever via the Hypothalamus

- Systemic Manifestations and Other Symptoms

6. Phagocytic Immune Cells

- Macrophages

- Antigen Presentation

- Cytokine Release

- Neutrophils

- Role in Early Innate Immune Response

7. Transition to Adaptive Immune Response

- Specificity

- Role of T Cells and B Cells

- Immunological Memory

8. Implications of Inefficient Adaptive Immune Response Activation

- Chronic Infection and Inflammation

- Cause: Disruption in Antigen Presentation

9. Biotoxin Illness and Genetic Factors

- Role of HLA Genes

- Chronic Inflammatory Response Syndrome

10. Mitigating Herx Reactions

- Slow Titration of Antimicrobial Therapy

- Reducing Inflammation: Omega-3s, SPMs, Curcumin, Quercetin, Ginger, Boswellia, etc.

- Supporting Clearance Pathways

- Liver, Lymph, Kidneys

- Hydration and Proper Elimination

- Epsom Salt Baths

- Use of Binders: Activated Charcoal, Chlorella, Cholestyramine etc.

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By Chloe Porter

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