May 17, 2024

119. HPA-Axis Dysfunction & The Adrenal Gland Peptide Bioregulator, Glandokort (+ A Deep Dive into How Bioregulators Work)

21 minutes

In this episode, we delve into the science behind peptide bioregulators, specifically focusing on Glandokort, a natural extract from the adrenal gland. We explore the unique characteristics and mechanisms of peptide bioregulators, highlighting their tissue-specific effects and role in gene regulation. Additionally, we provide an overview of the adrenal glands' anatomy and functions, and discuss how Glandokort may aid in normalizing adrenal gland protein synthesis in the context of some types of adrenal insufficiency.

Understanding Peptides

Definition of peptides: Short chains of amino acids

Comparison of peptide bioregulators and other peptides (e.g., BPC-157)

Size and function of peptide bioregulators

Bioregulators penetrate the cell membrane AND the nuclear membrane

Function of Peptide Bioregulators

Role in restoring organ balance

Tissue-specific effect

Gene Regulation and Cellular Differentiation

Importance of gene regulation

Nuance of cell differentiation and gene expression

Today's focus: gene regulation impacting a cell's functional activity

Mechanism of Bioregulators

Interaction with DNA and gene expression

Binding to histone proteins

Promotion of gene expression in tissue-specific cells

History and Development of Peptide Bioregulators

Early isolation from animal tissues

Examples of tissues used for extraction

Development of the synthetic peptide bioregulators

Natural vs. Synthetic Peptide Bioregulators

Availability of natural and synthetic supplements

Focusing on the natural extract of the adrenal gland: Glandokort

Adrenal Glands Overview

Location and function of adrenal glands

Division into cortex and medulla

7.1 Adrenal Cortex

Zona Glomerulosa: Production of mineralocorticoids (aldosterone)

Zona Fasciculata: Production of glucocorticoids (cortisol)

Zona Reticularis: Production of androgens

7.2 Adrenal Medulla

Production of catecholamines (adrenaline and noradrenaline)

Role in 'fight or flight' response

Glandokort Supplement

Description: Natural adrenal gland peptides

Function: Normalizing adrenal gland protein synthesis

Context of HPA-axis dysfunction or "adrenal fatigue"

Importance of working with a licensed medical professional

More research is needed

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By Chloe Porter

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