June 14, 2024

124. Methylation - MTHFR Gene Variants, Under-Methylation and its Impact on Mold or Lyme (& Detoxification in General), Helpful forms of Vitamin B9, & More

26 minutes

In this episode, we dive into the critical process of methylation and its significance in detoxification, mood regulation, and overall cellular function. We explain the step-by-step conversion of dietary folate to its active form and how gene mutations can impair this process, leading to reduced SAMe levels, high homocysteine, and various health issues. Finally, we discuss practical strategies to support methylation through dietary choices and targeted supplementation.

Topics:

1. Introduction

- Overview of previous discussions on Lyme and its coinfections (Babesia and Bartonella)

- Transition to the importance of supporting detoxification pathways

2. The Role of Methylation in Health

- Definition and significance of methylation

- Importance in detoxification, mood, energy, and gene activation

3. Methylation Process

- Biochemical explanation of methylation

- Key molecules involved: S-adenosylmethionine (SAMe), methionine, ATP

- Dietary sources and conversion process of folate (vitamin B9)

4. Synthesis of S-adenosylmethionine (SAMe)

- Step-by-step process from dietary folate to SAMe

- Enzymatic conversions: DHFR, MTHFR

- Role of active folate (L-5-MTHF) in methylation

5. Gene Mutations and Their Impact

- Common MTHFR gene mutations: C677T and A1298C

- Effects of reduced MTHFR enzyme activity

- Consequences: elevated homocysteine levels, reduced SAMe production

6. Consequences of Impaired Methylation

- DNA methylation and gene expression

- Neurotransmitter synthesis and mental health

- Detoxification efficiency

- Accumulation of unmetabolized folic acid

7. Supporting Methylation

- Dietary strategies:

- Emphasizing natural folate intake

- Food sources: leafy greens, legumes, fruits

- Supplementation strategies:

- Ensuring adequate intake of vitamin B12 and B6

- Using L-5-MTHF instead of synthetic folic acid

- Trimethylglycine (TMG) supplementation

Thank you to our episode sponsor: GenuinePurity

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By Chloe Porter

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